Point-of-care haemoglobin measurement - state of the art or a bleeding nuisance?

Background: While significant strides have been made to avoid mortality during the treatment of chronic diseases, it is still one of the biggest health-care challenges that have a profound effect on humanity. The development of specific, sensitive, accurate, quick, low-cost, and easy-to-use diagnostic tools is therefore still in urgent demand. Nanodiagnostics is defined as the application of nanotechnology to medical diagnostics that can offer many unique opportunities for more successful and efficient diagnosis and treatment for infectious diseases. Methods: In this review we provide an overview of infectious disease using nanodiagnostics platforms based on nanoparticles, nanodevices for point-of-care (POC) applications. Results: Current state-of-the-art and most promising nanodiagnostics POC technologies, including miniaturized diagnostic tools, nanorobotics and drug delivery systems have been fully examined for the diagnosis of diseases. It also addresses the drawbacks, problems and potential developments of nanodiagnostics in POC applications for chronic diseases. Conclusions: While progress is gaining momentum in this field and many researchers have dedicated their time in developing new smart nanodevices for POC applications for various chronic diseases, the ultimate aim of achieving longterm, reliable and continuous patient monitoring has not yet been achieved. Moreover, the applicability of the manufactured nanodevices to rural patients for on-site diagnosis, cost, and usability are the crucial aspects that require more research, improvements, and potential testing stations. Therefore, more research is needed to develop the demonstrated smart nanodevices and upgrade their applicability to hospitals away from the laboratories.

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COVID-19 mimics on chest CT: a pictorial review and radiologic guide

British Journal of Radiology ◽

10.1259/bjr.20200703 ◽

2020 ◽

pp. 20200703

Author(s):

Bruno Hochhegger ◽

Matheus Zanon ◽

Stephan Altmayer ◽

Nicole S Mandelli ◽

Guilherme Stüker ◽

...

Keyword(s):

Interstitial Pneumonia ◽

State Of The Art ◽

Point Of Care ◽

Fat Embolism ◽

Chest Ct ◽

Pulmonary Infections ◽

Pneumocystis Jiroveci ◽

Cryptogenic Organizing Pneumonia ◽

Chronic Eosinophilic Pneumonia ◽

Pictorial Review

Chest imaging is often used as a complementary tool in the evaluation of coronavirus disease 2019 (COVID-19) patients, helping physicians to augment their clinical suspicion. Despite not being diagnostic for COVID-19, chest CT may help clinicians to isolate high suspicion patients with suggestive imaging findings. However, COVID-19 findings on CT are also common to other pulmonary infections and non-infectious diseases, and radiologists and point-of-care physicians should be aware of possible mimickers. This state-of-the-art review goal is to summarize and illustrate possible etiologies that may have a similar pattern on chest CT as COVID-19. The review encompasses both infectious etiologies, such as non-COVID viral pneumonia, Mycoplasma pneumoniae, Pneumocystis jiroveci, and pulmonary granulomatous infectious, and non-infectious disorders, such as pulmonary embolism, fat embolism, cryptogenic organizing pneumonia, non-specific interstitial pneumonia, desquamative interstitial pneumonia, and acute and chronic eosinophilic pneumonia.

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State-of-the-art mass spectrometry for point-of-care and other applications: A hands-on intensive short course for undergraduate students

International Journal of Mass Spectrometry ◽

10.1016/j.ijms.2017.04.008 ◽

2017 ◽

Vol 417 ◽

pp. 22-28 ◽

Cited By ~ 10

Author(s):

Patrick W. Fedick ◽

Ryan M. Bain ◽

Shunshun Miao ◽

Valentina Pirro ◽

R. Graham Cooks

Keyword(s):

Mass Spectrometry ◽

Undergraduate Students ◽

State Of The Art ◽

Point Of Care ◽

Short Course ◽

Hands On

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Nanosensors for therapeutic drug monitoring: implications for transplantation

Nanomedicine ◽

10.2217/nnm-2019-0150 ◽

2019 ◽

Vol 14 (20) ◽

pp. 2735-2747 ◽

Cited By ~ 8

Author(s):

Ashkan Shafiee ◽

Elham Ghadiri ◽

Jareer Kassis ◽

Anthony Atala

Keyword(s):

State Of The Art ◽

Point Of Care ◽

Therapeutic Drug ◽

Organ Rejection ◽

Number Of Patients ◽

Deceased Donors ◽

Transplanted Organs ◽

Further Development

The number of patients requiring organ transplantations is exponentially increasing. New organs are either provided by healthy or deceased donors, or are grown in laboratories by tissue engineers. Post-surgical follow-up is vital for preventing any complications that can cause organ rejection. Physiological monitoring of a patient who receives newly transplanted organs is crucial. Many efforts are being made to enhance follow-up technologies for monitoring organ recipients, and point-of-care devices are beginning to emerge. Here, we describe the role of biosensors and nanosensors in improving organ transplantation efficiency, managing post-surgical follow-up and reducing overall costs. We provide an overview of the state-of-the-art biosensing technologies and offer some perspectives related to their further development.

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