An evaluation of changes over time in the semen parameters data used for the World Health Organization semen analysis reference ranges

Andrology ◽  
2021 ◽  
Author(s):  
Ido Feferkorn ◽  
Liat Azani ◽  
Einav Kadour‐Peero ◽  
Ranit Hizkiyahu ◽  
Guy Shrem ◽  
...  
Keyword(s):  
World Health Organization ◽  
Semen Analysis ◽  
World Health ◽  
Semen Parameters ◽  
Reference Ranges ◽  
The World ◽  
Health Organization ◽  
Changes Over Time ◽  
Over Time

scholarly journals Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

2020 ◽  
Vol 25 (32) ◽  
Author(s):  
Erik Alm ◽  
Eeva K Broberg ◽  
Thomas Connor ◽  
Emma B Hodcroft ◽  
Andrey B Komissarov ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Data Dissemination ◽  
Sequence Data ◽  
Temporal Distribution ◽  
World Health ◽  
European Region ◽  
The World ◽  
Health Organization ◽  
Over Time

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.

scholarly journals The serum inhibin B concentration and reference ranges in normozoospermia

2015 ◽  
Vol 172 (6) ◽  
pp. 669-676 ◽  
Author(s):  
Anne-Laure Barbotin ◽  
Caroline Ballot ◽  
Julien Sigala ◽  
Nassima Ramdane ◽  
Alain Duhamel ◽  
...  
Keyword(s):  
Reference Range ◽  
Reference Group ◽  
Semen Analysis ◽  
Inhibin B ◽  
World Health ◽  
Semen Parameters ◽  
Case Group ◽  
Reference Ranges ◽  
Semen Parameter ◽  
Health Organization

ObjectiveAlthough an inhibin B assay may be useful in the assessment of testicular function in a number of genital conditions, reliable reference ranges are still lacking. The present study sought to establish the reference range for serum inhibin B by applying the updated Gen II assay.DesignThis prospective study included 818 men referred for semen analysis: 377 were normozoospermic (reference group) and 441 presented at least one abnormal semen parameter (case group).MethodsSemen parameters were interpreted according to the 2010 World Health Organization manual and David's modified classification for normal morphology. The inhibin B concentration was determined with the current ELISA.ResultsIn the reference group, the 2.5th percentile for inhibin B was 92 pg/ml and the 97.5th percentile for FSH was 7.8 IU/l. In the overall population, an inhibin B level <92 pg/ml was associated with increased odds ratio (OR; 95% CI) for oligozoospermia (16.93 (9.82–29.18), P<0.0001), asthenozoospermia (4.87 (2.88–8.10), P<0.0001), and teratozoospermia (2.20 (1.31–3.68), P=0.0026). The combination of a FSH >7.8 IU/l and an inhibin B <92 pg/ml was associated with greater OR for oligozoospermia (98.74 (23.99–406.35), P<0.0001) than for each hormone considered separately.ConclusionsA new reference range for serum inhibin B was established by the use of updated immunoassay. The correlations between hormone levels and semen parameters highlighted the importance of establishing these values with respect to the spermogram. When combined with FSH assay, the inhibin B range may be of value in the evaluation of spermatogenesis in a number of male genital conditions.

P–059 Association between seminal levels of Fe and semen quality

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
R Rodrigue. Díaz ◽  
L Alcaide-Ruggiero ◽  
R Blane. Zamora ◽  
J Gome. Rodríguez ◽  
S Paz ◽  
...  
Keyword(s):  
Male Infertility ◽  
World Health Organization ◽  
Seminal Plasma ◽  
Semen Quality ◽  
Semen Analysis ◽  
The Other ◽  
World Health ◽  
The World ◽  
Metal Detection ◽  
Health Organization

Abstract Study question The detection of metals in semen offers a new field in the study of male infertility. Summary answer Normozoospermia is associated with higher amounts of Fe. In males with pathological spermiogram, the percentage of men with Fe in semen was lower than expected. What is known already Increased levels of Fe in human semen appear to have a significant correlation with male fertility, suggesting that Fe in human seminal plasma has an important factor in male reproductive function. Fe acts as an antioxidant being a co-factor of catalasa, which protects sperm. On the other hand, elevated Fe levels are associated with sperm damage and continues to increase the lipid peroxidation that will affect the plasma membrane and the sperm motility. Most authors associate Fe with sperm motility and higher estimated fertility potential, based on standard semen parameters in fertile men, which are associated with lower levels of Fe. Study design, size, duration A prospective study was carried out in 102 men in a Reproduction unit in Tenerife, from February to April 2018 as a part on an epidemiologic study of environmental contaminants and male reproduction. The participant were categorized into two groups, according to the results of semen analysis following the World Health Organization guidelines: the pathological and the normal semen group that constituted the control group. The metal was determined in semen samples. Participants/materials, setting, methods Semen quality and levels of Fe were measured in seminal plasma on a total of 102 men attended successively, for the initial infertility evaluation, The collected samples were used for both semen analysis following the World Health Organization (WHO) guidelines and metal detection and carried out using a Makler® counting chamber (Irvine Scientific, CA) and for metals, were determined by ICP-OES (Inductively Coupled Plasma-Optical Emission Spectrometry) in semen samples. Main results and the role of chance The percentage of males with the presence of Fe was 97.1% and the average level were 0.6283 mg/Kg. When analyzing the relationship between the spermiogram parameters with the levels of Fe in the semen, significant differences were found. All men with a normal sperm analysis presented Fe in semen, but among men diagnosed with altered spermiogram, the percentage of men with Fe in semen (92.7%) was lower than expected (97%) (χ2 128 1 =4.59; p = 0.032). As for the concentration of Fe in spermiogram in the first quartile (25% lower), measuring 0.33 mg/Kg, more pathological samples were found than expected (X2 133 2 =6.921; p = 0.031) having a higher probability of being more pathological (52% vs 31.4%). On the other hand, men with pathological sperm concentration, have higher levels of Fe, in the fourth quartile (0.61 mg/kg), with more frequency than expected (90.6% vs 97%) (χ2 136 1 =6.48; p = 0.011). The association between BMI and the presence of Fe was statistically significant. In obese males (BMI ≥30.0 kg/m2), the percentage of men with Fe in semen (80%) was lower than expected (97%) (χ2 42 2 =11.302; p = 0.001). Limitations, reasons for caution The limitation of this study was the volume of semen that could be obtained for metal detection, only 0.8 mL. because the collected samples were used for both semen analysis and metal detection. Wider implications of the findings: The determination of metals in semen opens a new field in the study of male infertility and many cases of unknown infertility could be due to metal presence or absence in semen, with the option of performing treatments. Trial registration number Not applicable

scholarly journals New World Health Organization reference values for semen analysis: where do we stand?

2013 ◽  
Vol 11 (2) ◽  
pp. 263-264 ◽  
Author(s):  
Marcelo Vieira
Keyword(s):  
World Health Organization ◽  
Reference Values ◽  
New World ◽  
Semen Analysis ◽  
Population Based ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
References Values

Semen analysis is of paramount importance to study potential male fertility, couple's infertility, the effects of gonadotoxic agents on spermatogenesis and as follow-up test during treatment of male infertility. Since 1987, the World Health Organization proposes the standardization of this test and its reference values based on population-based data. The latest version of the World Health Organization guidelines was published in 2010. It introduced a new methodology that produced new references values, which triggered a discussion that lies inconclusive. We revised the original World Health Organization paper focusing on methodological changes and its results, the new references values and their impact on clinical practice.

scholarly journals Recognition and liquid authority

2017 ◽  
Vol 9 (2) ◽  
pp. 311-328 ◽  
Author(s):  
Ole Jacob Sending
Keyword(s):  
World Health Organization ◽  
Security Council ◽  
World Health ◽  
Dynamic Features ◽  
Un Security Council ◽  
The World ◽  
Core Concepts ◽  
Relational Aspect ◽  
Health Organization ◽  
Over Time

To analyze how authority emerges, become institutionalized, and may be transformed, we are best served with a concept of authority that highlights its dynamic features, and that captures the multiplicity of actors involved in producing and sustaining it. Extant accounts tend to operate with a view of ‘solid’ authority, but such a concept of authority is mainly descriptive, not explanatory. A turn to the liquid features of authority is not only better suited to account for global authority, but also for those pockets of ‘solid’ authority that we can find in the global or international sphere. I develop an account of authority that draws selectively from some of Bourdieu’s core concepts and highlight the inherently relational aspect of authority. Authority, I submit, is based on actors’ search for recognition. Such a perspective is better able to account for how authority emerges and may stabilize as ‘solid,’ and also be transformed over time. I draw on examples from the World Health Organization and the UN Security Council to illustrate the argument.

scholarly journals Semen analysis: update on clinical value, current needs and future perspectives

Reproduction ◽  
2013 ◽  
Vol 146 (6) ◽  
pp. R249-R258 ◽  
Author(s):  
Victoria Sánchez ◽  
Joachim Wistuba ◽  
Con Mallidis
Keyword(s):  
Semen Analysis ◽  
Reproductive Function ◽  
World Health ◽  
Semen Parameters ◽  
Reference Ranges ◽  
Clinical Value ◽  
New Era ◽  
Analytical Instruments ◽  
Male Reproductive Function ◽  
Health Organization

At present, evaluation of male reproductive function consists primarily of routine semen analysis, a collection of conventional microscopic assessments ideally performed following the guidelines set by the World Health Organization. While providing some insight into testicular function, these long-performed tests are limited in the information that they impart; more specifically, they are unable to predict true fertility potential. As a consequence, there is a need for the appraisal and consideration of newer semen parameters that may be more indicative of reproductive success. Although various novel assays have been introduced that broaden the scope of information available to both researcher and clinician, the utility of these tests remains limited due to the lack of standardisation of protocols and the absence of clinically established, dependable reference ranges. As such, it is not surprising that most of these parameters and their associated methods remain recommended for ‘research purposes only’. With the burgeoning ‘omics’ revolution, nanotechnology and the development of new analytical instruments, there is now an opportunity for the identification and measurement of previously unknown features that may prove to be more indicative of each sperm's true functional status and capability. Once optimised, simplified, clinically validated and made more readily accessible, these new approaches hold the promise of forming the fulcrum upon which andrological investigations can enter a new era.

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