Association of the 5-HT2Areceptor gene promoter polymorphism-1438G/A with anorexia nervosa and psychopathological traits in the Chinese Han population: A preliminary study

2017 ◽  
Vol 9 (3) ◽  
pp. e12284 ◽  
Author(s):  
Qing Kang ◽  
Jue Chen ◽  
Shunying Yu ◽  
Aihua Yuan ◽  
Yanxia Zhang ◽  
...  
2004 ◽  
Vol 92 (10) ◽  
pp. 867-873 ◽  
Author(s):  
Xiaoyang Zhou ◽  
Jianfeng Huang ◽  
Jianhong Chen ◽  
Shaoyong Su ◽  
Runsheng Chen ◽  
...  

SummaryMatrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population. The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls. The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the -1612 5A/6A polymorphism. We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.


The Lancet ◽  
1997 ◽  
Vol 350 (9075) ◽  
pp. 412 ◽  
Author(s):  
David A Collier ◽  
Maria J Arranz ◽  
Tao Li ◽  
Dennis Mupita ◽  
Nigel Brown ◽  
...  

2009 ◽  
Vol 74 (1) ◽  
pp. 11-16 ◽  
Author(s):  
P. C. Cai ◽  
L. H. Hu ◽  
T. P. Cui ◽  
Y. R. Li ◽  
F. H. Chen ◽  
...  

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