scholarly journals Treatment with tenofovir disoproxil fumarate or entecavir in chronic hepatitis B virus-infected patients with renal impairment: results from a 7-year, multicentre retrospective cohort study

2020 ◽  
Vol 52 (3) ◽  
pp. 500-512 ◽  
Author(s):  
Pietro Lampertico ◽  
Thomas Berg ◽  
Maria Buti ◽  
Anita Pathil ◽  
Joerg Petersen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Cohort Study ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Renal Impairment ◽  
Retrospective Cohort Study ◽  
Tenofovir Disoproxil Fumarate ◽  
Retrospective Cohort ◽  
Chronic Hepatitis B Virus ◽  
B Virus

scholarly journals Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xing-Ran Zhai ◽  
Jing-Jing Tong ◽  
Hong-Min Wang ◽  
Xiang Xu ◽  
Xiu-Ying Mu ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
B Virus

Abstract Background Infection is common in acute-on-chronic liver failure (ACLF), which may worsen the clinical condition and prognosis. However, the characteristics of infection and its influence on prognosis in hepatitis B virus related ACLF (HBV-ACLF) as defined by the European Association for the Study of the Liver (EASL) have not been clarified. We aimed to investigate the characteristics of infection and its influence on mortality in patients with HBV-ACLF defined by EASL in China. Methods We performed a retrospective cohort study in patients with HBV-ACLF defined by EASL in a single center from January 2015 to December 2017. These patients were divided into two groups with and without infection. The incidence, sites of infection, isolated strains, and risk factors associated with mortality were evaluated. Results A total of 289 patients were included, among them 185 (64.0%) were diagnosed with an infection. The most common type of infection was pneumonia (55.7%), followed by spontaneous bacterial peritonitis (47.6%) and others. The gram-negative bacteria were the most frequent (58.3%). Patients with one, two, and three or more infection sites had a gradually increasing incidence of sepsis (P < 0.01), septic shock (P < 0.001), and ACLF-3 (P < 0.05). Also, patients with infection isolated one, two, and three or more strains showed a growing incidence of sepsis (P < 0.01) and septic shock (P < 0.001). Patients with infection showed a significantly higher 28-day mortality than those without (P < 0.01), especially in patients with ACLF-3. Infection was identified as an independent risk factor for 28-day mortality in all HBV-ACLF patients. Pneumonia and sepsis were identified as independent predictors of 28-day mortality for patients with infection. Conclusions Infection is associated with severe clinical course and high mortality in HBV-ACLF defined by EASL. The increased number of infection sites or isolated strains was associated with the occurrence of sepsis and septic shock. Pneumonia and sepsis were independent predictors for mortality in HBV-ACLF patients with infection.

scholarly journals Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e027696 ◽  
Author(s):  
Jiahui Si ◽  
Canqing Yu ◽  
Yu Guo ◽  
Zheng Bian ◽  
Ruogu Meng ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Cohort Study ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Specific Mortality ◽  
Chronic Hbv

ObjectivesChronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality.DesignPopulation-based prospective cohort study.SettingChina Kadoorie Biobank in which participants from 10 geographically diverse areas across China were enrolled between 2004 and 2008.Participants475 801 participants 30–79 years of age without reporting major chronic diseases at baseline were enrolled. Hepatitis B surface antigen (HBsAg) was tested using an on-site rapid test strip at baseline.Primary and secondary outcome measuresTotal and cause-specific mortality.ResultsA total of 35 822 deaths were recorded during ~10 years of follow-up. In multivariable-adjusted analyses, compared with HBsAg-negative participants, HBsAg-positive participants had an increased risk of total mortality (HR=2.01, 95% CI: 1.91 to 2.12), which was higher in men (HR=2.16, 95% CI: 2.01 to 2.31) than in women (HR=1.74, 95% CI: 1.60 to 1.90). Presence of HBsAg was associated with increased mortality from liver cancer (1339 deaths, HR=13.95, 95% CI: 12.46 to 15.62), infections (410 deaths, HR=10.30, 95% CI: 8.21 to 12.94), digestive diseases (688 deaths, HR=6.83, 95% CI: 5.49 to 8.50), intracerebral haemorrhage (4077 deaths, HR=1.38, 95% CI: 1.14 to 1.68) and ischaemic heart diseases (4624 deaths, HR=1.31, 95% CI: 1.09 to 1.58). The positive association between HBsAg status and risk of death was stronger in participants younger than 50 years, smokers, physically active or non-hypertensive participants.ConclusionsAmong Chinese adults, chronic HBV infection was associated with increased mortality from a range of hepatic and extrahepatic diseases.

scholarly journals Molecular epidemiology of hepatitis B virus infection in Switzerland: a retrospective cohort study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Cédric Hirzel ◽  
Gilles Wandeler ◽  
Marta Owczarek ◽  
Meri Gorgievski-Hrisoho ◽  
Jean-Francois Dufour ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Molecular Epidemiology ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hepatitis B Virus Infection ◽  
B Virus

scholarly journals Ten‐year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B virus infection

2019 ◽  
Vol 39 (10) ◽  
pp. 1868-1875 ◽  
Author(s):  
Patrick Marcellin ◽  
David K Wong ◽  
William Sievert ◽  
Peter Buggisch ◽  
Jörg Petersen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Tenofovir Disoproxil Fumarate ◽  
Hepatitis B Virus Infection ◽  
Efficacy And Safety ◽  
Chronic Hepatitis B Virus ◽  
B Virus

scholarly journals Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

2020 ◽  
Author(s):  
Xing-Ran Zhai ◽  
Jing-Jing Tong ◽  
Hong-Min Wang ◽  
Xiang Xu ◽  
Xiu-Ying Mu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Infection Group ◽  
B Virus

Abstract Background: Infection is common in acute-on-chronic liver failure (ACLF), which may worsen the clinical condition and prognosis. However, the characteristics of infection and its influence on prognosis in hepatitis B virus related ACLF (HBV-ACLF) as defined by the European Association for the Study of the Liver (EASL) have not been clarified. We aimed to investigate the characteristics of infection and its influence on mortality in HBV-ACLF defined by EASL in China.Methods: We performed a retrospective cohort study with HBV-ACLF patients defined by EASL in a single center from January 2015 to December 2017. Patients were divided into an infection group and a non-infection group. The incidence, sites, strains of infection, and risk factors for mortality were evaluated. Results: A total of 289 patients were included, of which 185 (64.0%) were diagnosed with an infection. The most common was pneumonia (55.7%), followed by spontaneous bacterial peritonitis (47.6%) and others. The gram-negative bacteria were the most frequent (58.3%). Patients with one, two, and three or more infection sites had a gradually increasing incidence of sepsis (P<0.01), sepsis shock (P<0.001), and ACLF-3 (P<0.05). One, two, and three or more strains were isolated in 86, 16, and 18 patients, who showed a growing incidence of sepsis (P<0.01) and sepsis shock (P<0.001). Infection was identified as an independent risk factor for 28-day mortality in HBV-ACLF patients. Infected patients showed a significantly higher 28-day mortality than those without (P<0.01), especially in patients with ACLF-3. Pneumonia and sepsis were identified as independent predictors of 28-day mortality for infected patients.Conclusions: Infection is associated with severe clinical course and high mortality in HBV-ACLF defined by EASL. The increased incidence of sepsis and sepsis shock was associated with an increased number of infection sites and isolated strains. Pneumonia and sepsis were independent predictors affecting mortality in HBV-ACLF patients with infection.

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