Pharmacokinetics and brain sigma 1 (σ1) receptor occupancy of MR309, a selective σ1 receptor antagonist

2021 ◽  
Author(s):  
Eugenii A. Rabiner ◽  
Kevin Smith ◽  
Carla Bennett ◽  
Gaia Rizzo ◽  
Yvonne Lewis ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Receptor Occupancy ◽  
Σ1 Receptor ◽  
Sigma 1

scholarly journals Erratum to: Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with 11C-SA4503 and microPET

2014 ◽  
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Nisha K. Ramakrishnan ◽  
Anniek K. D. Visser ◽  
Marianne Schepers ◽  
Gert Luurtsema ◽  
Csaba J. Nyakas ◽  
...  
Keyword(s):  
Rat Brain ◽  
Receptor Occupancy ◽  
Sigma 1 Receptor ◽  
Sigma 1 ◽  
Dose Dependent

scholarly journals Relationship between Cerebral Sigma-1 Receptor Occupancy and Attenuation of Cocaine’s Motor Stimulatory Effects in Mice by PD144418

2014 ◽  
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pp. 153-163 ◽  
Author(s):  
John R. Lever ◽  
Dennis K. Miller ◽  
Emily A. Fergason-Cantrell ◽  
Caroline L. Green ◽  
Lisa D. Watkinson ◽  
...  
Keyword(s):  
Receptor Occupancy ◽  
Sigma 1 Receptor ◽  
Sigma 1

Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

2011 ◽  
Vol 54 (23) ◽  
pp. 8000-8012 ◽  
Author(s):  
Charles H. Mitch ◽  
Steven J. Quimby ◽  
Nuria Diaz ◽  
Concepcion Pedregal ◽  
Marta G. de la Torre ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Receptor Occupancy ◽  
Preclinical Development ◽  
Opioid Receptor Antagonist ◽  
Selective Antagonists

scholarly journals A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, and Wake-Promoting and Procognitive Effects in Rodents

2020 ◽  
Vol 375 (2) ◽  
pp. 276-285
Author(s):  
Noriko Hino ◽  
Toshiyuki Marumo ◽  
Makiko Kotani ◽  
Toshiharu Shimazaki ◽  
Ayaka Kaku-Fukumoto ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Receptor Occupancy ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Histamine H3

EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management

2020 ◽  
Vol 63 (23) ◽  
pp. 14979-14988
Author(s):  
José Luis Díaz ◽  
Mónica García ◽  
Antoni Torrens ◽  
Ana María Caamaño ◽  
Juan Enjo ◽  
...  
Keyword(s):  
Pain Management ◽  
Receptor Antagonist ◽  
Σ1 Receptor ◽  
Clinical Candidate

scholarly journals Analysis of 5-HT3 Receptor Antagonist, Ramosetron Hydrochloride, Based on Receptor Occupancy Considering Its Active Metabolite

2001 ◽  
Vol 121 (11) ◽  
pp. 793-798 ◽  
Author(s):  
Akiko OGATA ◽  
Yasuhiko YAMADA ◽  
Munetoshi SUGIURA ◽  
Risa TAKAYANAGI ◽  
Yasufumi SAWADA ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Active Metabolite ◽  
Receptor Occupancy

173 IN VIVO CHARACTERISATION OF THE NEW SELECTIVE SIGMA-1 RECEPTOR ANTAGONIST (S1RA): POTENTIAL USE FOR THE TREATMENT OF NEUROPATHIC PAIN

2010 ◽  
Vol 4 (S1) ◽  
pp. 52-52
Author(s):  
M. Fort ◽  
G. Gris ◽  
B. Aubel ◽  
A. Vidal ◽  
L. Romero ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Receptor Antagonist ◽  
Sigma 1 Receptor ◽  
Sigma 1 ◽  
Potential Use
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