Myeloid sarcoma of the vulva as the initial presentation of acute myeloid leukaemia

2015 ◽  
Vol 174 (1) ◽  
pp. 234-236 ◽  
Author(s):  
S.C.‐S. Hu ◽  
W.‐T. Chen ◽  
G.‐S. Chen
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Acute Myeloid

scholarly journals Myeloid Sarcoma of the Orbit Preceding Acute Myeloid Leukaemia: A Diagnostic Challenge

2019 ◽  
Vol 11 (14) ◽  
pp. 98
Author(s):  
Oluomachi Charity Nnachi ◽  
Robert Azu Nnachi ◽  
Innocent Paul Ezenwenyi ◽  
Ogah Emeka Onwe ◽  
Augustine Ejike Okoye ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Condition ◽  
Tumour Progression ◽  
Correct Diagnosis ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Orbital Mass ◽  
Management Of Complications ◽  
Acute Myeloid

Objective: Myeloid sarcoma is a rare form of acute myeloid leukaemia characterized by extramedullary proliferation of myeloid blasts which can occur as an isolated lesion in any organ. Even rarer it may occur in the orbit as the initial presentation without a leukaemic phase and diagnosis may be challenging when it is not suspected.           Methods: We report a case of orbital myeloid sarcoma as the initial presentation of acute myeloid leukaemia in an adult who was misdiagnosed and treated as a case of a pseudotumour with resultant significant disease progression and worsening of the clinical condition. There was a lag of four months from the onset of eye mass to the development of acute myeloid leukaemia. Result: Due to patients worsening condition and tumour progression, a repeat biopsy for a second histology opinion at a different facility, immunophenotyping and immunohistochemistry were employed to arrive at the correct diagnosis. Following chemotherapy, the orbital mass reduced markedly and clinical condition improved. The patient was indigent and could not sustain further funding of his treatment because he had already spent much on for management of complications he developed before a definitive diagnosis could be made. Conclusion: Myeloid sarcoma can present as an orbital mass without a leukemic disease. Therefore a high index of suspicion, meticulous examination of biopsy, immunohistochemistry and collaboration between oncologists and ophthalmologists, are required to arrive at an early accurate diagnosis.

Unusual coexistence of sinonasal myeloid sarcoma and acute fulminant invasive fungal sinusitis: a diagnostic dilemma

2013 ◽  
Vol 127 (4) ◽  
pp. 415-418 ◽  
Author(s):  
C-L Kuo ◽  
Y-B Yu ◽  
W-Y Li ◽  
Y-L Lee
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Myeloid Sarcoma ◽  
Surgical Debridement ◽  
Comorbid Condition ◽  
Histopathological Analysis ◽  
Fungal Sinusitis ◽  
Diagnostic Dilemma ◽  
Invasive Fungal Sinusitis ◽  
Acute Myeloid

AbstractObjective:We report a rare case of concurrent myeloid sarcoma and acute fulminant invasive fungal sinusitis in a patient with relapsed acute myeloid leukaemia.Case report:A 73-year-old man was diagnosed with acute myeloid leukaemia and developed relapse one year later. After two courses of azacytidine, he began suffering from a dull pain in the left temporal and orbital regions. Sinus computed tomography showed a localised lesion in the left ethmoid sinus, which rapidly progressed to an extensive intracranial mass within one month. Surgical debridement was performed, and histopathological analysis revealed the coexistence of myeloid sarcoma and acute fulminant invasive fungal sinusitis. The patient responded well to prompt surgical debridement, antifungal medication and radiotherapy.Conclusion:Coexistence of sinonasal myeloid sarcoma and acute fulminant invasive fungal sinusitis poses an urgent diagnostic and management challenge to clinicians. Timely recognition of this rare comorbid condition is warranted as application of appropriate treatment can save lives.

A Relapsing Meningeal Acute Myeloid Leukaemia FLT3-ITD+ Responding to Gilteritinib

Chemotherapy ◽  
2021 ◽  
pp. 1-5
Author(s):  
Salvatore Perrone ◽  
Elettra Ortu La Barbera ◽  
Federica Viola ◽  
Elena Cipollone ◽  
Maria Cristina Scerpa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Residual Disease ◽  
Complete Response ◽  
Myeloid Sarcoma ◽  
Leg Pain ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
Acute Myeloid

A patient with a therapy-related acute myeloid leukaemia (AML), NPM1<sup>mut</sup>, and FLT3-ITD+ was treated with induction and consolidation with CPX-351, obtaining a complete response (CR) but minimal residual disease persisted positive. Later, she complained progressive burning leg pain, weakening of the right hand and leg muscles, associated with absence of osteotendinous leg reflexes. Examination of cerebrospinal fluid (CSF) showed a meningeal relapse of AML. Moreover, a magnetic resonance imaging (MRI) showed 2 right meningeal implants of myeloid sarcoma and bone marrow revealed haematologic relapse of disease. She was treated with medicated lumbar punctures (LPs) followed by an FLA-Ida scheme, and she achieved a 2nd CR. Unfortunately, the patient developed hyperleucocytosis and reappearance of meningeal myeloid sarcoma at MRI. For this reason, a monotherapy with gilteritinib (an FLT3 inhibitor) was started: after 3 months of therapy, central nervous system (CNS)-disease shrunken and then faded, while AML in the bone marrow achieved only a partial response. This is the 1st report of a positive biological effect of gilteritinib on CNS (meningeal) myeloid sarcoma. There are no studies of gilteritinib concentration into CSF and penetration of gilteritinib into the blood-brain barrier should be further studied, given the paucity of drugs active on CNS relapse of AML. In patients receiving CPX-351 only, diagnostic LP should be considered after induction.

scholarly journals Myeloid Sarcoma of the Uterine Cervix as Presentation of Acute Myeloid Leukaemia after Treatment with Low-Dose Radioiodine for Thyroid Cancer: A Case Report and Review of the Literature

2009 ◽  
Vol 2 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Anne Sophie Weingertner ◽  
Marc Wilt ◽  
Ihab Atallah ◽  
Cécile Fohrer ◽  
Laurent Mauvieux ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Uterine Cervix ◽  
Low Dose ◽  
Myeloid Sarcoma ◽  
Review Of The Literature ◽  
Acute Myeloid

Initial presentation of acute myeloid leukaemia as collision intradermal melanocytic naevus and myeloid leukaemia cutis mimicking naevoid melanoma

Pathology ◽  
2019 ◽  
Vol 51 (4) ◽  
pp. 441-443
Author(s):  
Laurence Galea ◽  
Chin-Guan Tan ◽  
Peter I.A. McQuillan ◽  
Sant Khan ◽  
Christopher Mow
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Initial Presentation ◽  
Melanocytic Naevus ◽  
Acute Myeloid

Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia

2006 ◽  
Vol 7 (4) ◽  
pp. 350-352 ◽  
Author(s):  
Niccolò Bolli ◽  
Sara Galimberti ◽  
Maria P Martelli ◽  
Alessia Tabarrini ◽  
Giovanni Roti ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Myeloid Sarcoma ◽  
Acute Myeloid

scholarly journals Acute Myeloid Leukaemia Diagnosed by Intra-Oral Myeloid Sarcoma. A Case Report

2010 ◽  
Vol 4 (2) ◽  
pp. 132-135 ◽  
Author(s):  
Mattheos K. Papamanthos ◽  
Alexandros E. Kolokotronis ◽  
Haralampos E. Skulakis ◽  
Angela-Monika A. Fericean ◽  
Matina T. Zorba ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Myeloid Sarcoma ◽  
Acute Myeloid

scholarly journals Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition

2018 ◽  
pp. bcr-2017-222718 ◽  
Author(s):  
Rodrigo Athayde Nemésio ◽  
Beatriz Costa ◽  
Carlos Abrantes ◽  
Júlio Soares Leite
Keyword(s):  
Small Intestine ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Rare Condition ◽  
Myeloid Sarcoma ◽  
Acute Myeloid
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