scholarly journals Hidradenitis Suppurativa Area and Severity Index ( HASI ): a pilot study to develop a novel instrument to measure the physical signs of hidradenitis suppurativa

2019 ◽  
Author(s):  
N. Goldfarb ◽  
J.R. Ingram ◽  
G.B.E. Jemec ◽  
H.B. Naik ◽  
V. Piguet ◽  
...  
Keyword(s):  
Pilot Study ◽  
Hidradenitis Suppurativa ◽  
Severity Index

scholarly journals Paliperidone ER in the Treatment of Borderline Personality Disorder: A Pilot Study of Efficacy and Tolerability

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Silvio Bellino ◽  
Paola Bozzatello ◽  
Camilla Rinaldi ◽  
Filippo Bogetto
Keyword(s):  
Borderline Personality Disorder ◽  
Pilot Study ◽  
Personality Disorder ◽  
Adverse Events ◽  
Mechanism Of Action ◽  
Severity Index ◽  
Borderline Personality ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Dsm Iv

Antipsychotics are recommended for the treatment of impulsive dyscontrol and cognitive perceptual symptoms of borderline personality disorder (BPD). Three reports supported the efficacy of oral risperidone on BPD psychopathology. Paliperidone ER is the metabolite of risperidone with a similar mechanism of action, and its osmotic release reduces plasmatic fluctuations and antidopaminergic effects. The aim of this study is to evaluate efficacy and safety of paliperidone ER in BPD patients. 18 outpatients with a DSM-IV-TR diagnosis of BPD were treated for 12 weeks with paliperidone ER (3–6 mg/day). They were assessed at baseline, week 4, and week 12, using the CGI-Severity item, the BPRS, the HDRS, the HARS, the SOFAS, the BPD Severity Index (BPDSI), and the Barratt Impulsiveness Scale (BIS-11). Adverse events were evaluated with the DOTES. Paliperidone ER was shown to be effective and well tolerated in reducing severity of global symptomatology and specific BPD symptoms, such as impulsive dyscontrol, anger, and cognitive-perceptual disturbances. Results need to be replicated in controlled trials.

scholarly journals Prospective, Comparative Clinical Pilot Study of Cold Atmospheric Plasma Device in the Treatment of Atopic Dermatitis

2021 ◽  
Author(s):  
Young Jae Kim ◽  
Dong Jun Lim ◽  
Mi Young Lee ◽  
Woo Jin Lee ◽  
Sung Eun Chang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Severity Index ◽  
Skin Lesions ◽  
Treated Group ◽  
Atmospheric Plasma ◽  
Clinical Severity ◽  
Control Treatment ◽  
Cold Atmospheric Plasma ◽  
Plasma Device

Abstract Introduction: Cold atmospheric plasma generates free radicals through the ionization of air at room temperature. Its effect and safety profile in patients with atopic dermatitis have not been evaluated prospectively.Objective: We aimed to investigate the effect and safety of cold atmospheric plasma in patients with atopic dermatitis with a prospective pilot study.Methods: Cold atmospheric plasma treatment or sham control treatment were applied respectively in randomly assigned and symmetric skin lesions. Three treatment sessions were performed at weeks 0, 1, and 2. Clinical severity indices were assessed at weeks 0, 1, 2, and 4 after treatment. Additionally, the microbial characteristics of the lesions before and after treatments were analyzed.Results: We included 22 patients with mild to moderate atopic dermatitis presented with symmetric lesions. We found that cold atmospheric plasma can alleviate the clinical severity of atopic dermatitis. Modified atopic dermatitis antecubital severity and eczema area and severity index score were significantly decreased in the treated group. Furthermore, scoring of atopic dermatitis score and pruritic visual analog scales significantly improved. In microbiome analysis revealed significantly reduced proportion of Staphylococcus aureus in the treated group.Conclusion: Cold atmospheric plasma can significantly improve mild and moderate atopic dermatitis without safety issues.

Could Residents Adequately Assess the Severity of Hidradenitis Suppurativa? Interrater and Intrarater Reliability Assessment of Major Scoring Systems

Dermatology ◽  
2019 ◽  
Vol 236 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Katarzyna Włodarek ◽  
Aleksandra Stefaniak ◽  
Łukasz Matusiak ◽  
Jacek C. Szepietowski
Keyword(s):  
Interrater Reliability ◽  
Hidradenitis Suppurativa ◽  
Intraclass Correlation ◽  
Scoring Systems ◽  
Staging System ◽  
Severity Index ◽  
Assessment Tools ◽  
Intrarater Reliability ◽  
Global Assessment Scale ◽  
Interrater Variability

A wide variety of assessment tools have been proposed for hidradenitis suppurativa (HS) until now, but none of them meets the criteria for an ideal score. Because there is no gold standard scoring system, the choice of the measure instrument depends on the purpose of use and even on the physician’s experience in the subject of HS. The aim of this study was to assess the intrarater and interrater reliability of 6 scoring systems commonly used for grading severity of HS: the Hurley Staging System, the Refined Hurley Staging, the Hidradenitis Suppurativa Severity Score System (IHS4), the Hidradenitis Suppurativa Severity Index (HSSI), the Sartorius Hidradenitis Suppurativa Score and the Hidradenitis Suppurativa Physician’s Global Assessment Scale (HS-PGA). On the scoring day, 9 HS patients underwent a physical examination and disease severity assessment by a group of 16 dermatology residents using all evaluated instruments. Then, intrarater reliability was calculated using intraclass correlation coefficient (ICC), and interrater variability was evaluated using the coefficient of variation (CV). In all 6 scorings the ICCs were >0.75, indicating high intrarater reliability of all presented scales. The study has also demonstrated moderate agreement between raters in most of the evaluated measure instruments. The most reproducible methods, according to CVs, seem to be the Hurley staging, IHS4, and HSSI. None of the 6 evaluated scoring systems showed a significant advantage over the other when comparing ICCs, and all the instruments seem to be very reliable methods. The interrater reliability was usually good, but the most repeatable results between researchers were obtained for the easiest scales, including Hurley scoring, IHS4 and HSSI.

scholarly journals IDDF2019-ABS-0293 A microbiome pilot study: the exploration of the gut-skin axis in hidradenitis suppurativa

2019 ◽  
Author(s):  
Suk Yee Lam ◽  
Djawad Radjabzadeh ◽  
Hester Eppinga ◽  
Hessel H van der Zee ◽  
Robert Kraaij ◽  
...  
Keyword(s):  
Pilot Study ◽  
Hidradenitis Suppurativa

Hidradenitis Suppurativa Area and Severity Index Revised (HASI‐R): psychometric property assessment

2020 ◽  
Author(s):  
N. Goldfarb ◽  
M. A. Lowes ◽  
M. Butt ◽  
T. King ◽  
A. Alavi ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Psychometric Property ◽  
Severity Index ◽  
Property Assessment

scholarly journals Botulinum Toxin Type B for Hidradenitis Suppurativa: A Randomised, Double-Blind, Placebo-Controlled Pilot Study

2020 ◽  
Vol 21 (5) ◽  
pp. 741-748
Author(s):  
Øystein Grimstad ◽  
Bjørn Øivind Kvammen ◽  
Carl Swartling
Keyword(s):  
Botulinum Toxin ◽  
Pilot Study ◽  
Hidradenitis Suppurativa ◽  
Botulinum Toxin Type ◽  
Type B ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Botulinum Toxin Type B

scholarly journals 635 A novel method for evaluating physical signs of hidradenitis suppurativa: A pilot study

2019 ◽  
Vol 139 (5) ◽  
pp. S109
Author(s):  
N.I. Goldfarb ◽  
J.R. Ingram ◽  
G.B. Jemec ◽  
H.B. Naik ◽  
V. Piguet ◽  
...  
Keyword(s):  
Pilot Study ◽  
Hidradenitis Suppurativa ◽  
Novel Method

Pilot study of fractional microneedling radiofrequency for hidradenitis suppurativa assessed by clinical response and histology

2021 ◽  
Author(s):  
J.H. Yang ◽  
S.I. Cho ◽  
D.H. Kim ◽  
J.Y. Yoon ◽  
J. Moon ◽  
...  
Keyword(s):  
Pilot Study ◽  
Clinical Response ◽  
Hidradenitis Suppurativa

Hidradenitis suppurativa: a pilot study to determine the capability of patients to self-assess their Hurley stage

2015 ◽  
Vol 172 (5) ◽  
pp. 1418-1419 ◽  
Author(s):  
I.E. Deckers ◽  
D. Mihajlović ◽  
E.P. Prens ◽  
J. Boer
Keyword(s):  
Pilot Study ◽  
Hidradenitis Suppurativa
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