scholarly journals Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors

2020 ◽  
Vol 177 (24) ◽  
pp. 5595-5608
Author(s):  
Praveen Kumar ◽  
Petra Scholze ◽  
Martin Fronius ◽  
Gabriela Krasteva‐Christ ◽  
Monika I. Hollenhorst
Keyword(s):  
Ion Transport ◽  
Ach Receptors

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Nlrp3 Inflammasome ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Therapeutic Interventions ◽  
Low Grade ◽  
Cardiovascular Research ◽  
Inflammatory Processes ◽  
Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

Ion transport and signalling in human labial glands

1999 ◽  
Vol 44 ◽  
pp. S15-S19 ◽  
Author(s):  
R Turner
Keyword(s):  
Ion Transport ◽  
Labial Glands

Characterization of acetylcholine-induced ion transport in human duodenum

2001 ◽  
Vol 120 (5) ◽  
pp. A532-A532
Author(s):  
R LARSEN ◽  
M HANSEN ◽  
N BINSLEV ◽  
A MERTZNIELSEN
Keyword(s):  
Ion Transport

Total parenteral nutrition changes intestinal ion transport and increases epithelial permeability in a mouse model

2001 ◽  
Vol 120 (5) ◽  
pp. A675-A675
Author(s):  
H YANG ◽  
F ROBERT ◽  
Y FAN ◽  
D TEITELBAUM
Keyword(s):  
Mouse Model ◽  
Parenteral Nutrition ◽  
Ion Transport ◽  
Total Parenteral Nutrition ◽  
Epithelial Permeability ◽  
Intestinal Ion Transport

Protein kinase inhibitor K-252a and fusicoccin induce similar initial changes in ion transport of parsley suspension cells

1992 ◽  
Vol 85 (3) ◽  
pp. 483-488
Author(s):  
Heinrich Kauss ◽  
Wolfgang Jeblick ◽  
Uwe Conrath
Keyword(s):  
Protein Kinase ◽  
Ion Transport ◽  
Kinase Inhibitor ◽  
Protein Kinase Inhibitor ◽  
Suspension Cells

Overview of Particle and Heavy Ion Transport Code System PHITS

2014 ◽  
Author(s):  
Tatsuhiko Sato ◽  
Koji Niita ◽  
Norihiro Matsuda ◽  
Shintaro Hashimoto ◽  
Yosuke Iwamoto ◽  
...  
Keyword(s):  
Ion Transport ◽  
Heavy Ion ◽  
Code System ◽  
Transport Code

Nasal epithelia cultures of patients with chronic rhinosinusitis show altered ion transport capacities

Pneumologie ◽  
2016 ◽  
Vol 70 (07) ◽  
Author(s):  
JJ Salomon ◽  
T Albrecht ◽  
H Scheuermann ◽  
I Baumann ◽  
MA Mall
Keyword(s):  
Ion Transport ◽  
Chronic Rhinosinusitis

ELECTRON AND ION TRANSPORT WITHIN THE HEAT GENERATION OF GRAPHENE-BASED SUPERCAPACITORS

2018 ◽  
Author(s):  
Jing Kong ◽  
Shenghao Wu ◽  
Huachao Yang ◽  
Zheng Bo
Keyword(s):  
Ion Transport ◽  
Heat Generation

Ion Transport through Biological Membranes

1975 ◽  
Author(s):  
Michael C. Mackey
Keyword(s):  
Ion Transport ◽  
Biological Membranes
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