scholarly journals The anti‐parasitic drug miltefosine suppresses human eosinophil activation and ameliorates murine allergic inflammation in vivo

2021 ◽  
Vol 178 (5) ◽  
pp. 1234-1248
Author(s):  
Eva Knuplez ◽  
Melanie Kienzl ◽  
Athina Trakaki ◽  
Rudolf Schicho ◽  
Akos Heinemann ◽  
...  
Keyword(s):  
Allergic Inflammation ◽  
Human Eosinophil ◽  
Eosinophil Activation

scholarly journals Lysophosphatidylcholines inhibit human eosinophil activation and suppress eosinophil migration in vivo

2020 ◽  
Vol 1865 (7) ◽  
pp. 158686 ◽  
Author(s):  
Eva Knuplez ◽  
Sanja Curcic ◽  
Anna Theiler ◽  
Thomas Bärnthaler ◽  
Athina Trakaki ◽  
...  
Keyword(s):  
Human Eosinophil ◽  
Eosinophil Migration ◽  
Eosinophil Activation

The Effect of Nedocromil Sodium on Human Eosinophil Activation

Drugs ◽  
1989 ◽  
Vol 37 (Supplement 1) ◽  
pp. 19-22 ◽  
Author(s):  
R. Moqbel ◽  
O. Cromwell ◽  
A. B. Kay
Keyword(s):  
Nedocromil Sodium ◽  
Human Eosinophil ◽  
Eosinophil Activation

Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo

2016 ◽  
Vol 83 (2) ◽  
pp. 106-115 ◽  
Author(s):  
Sarah Ehling ◽  
Kristine Roßbach ◽  
Stanley M. Dunston ◽  
Holger Stark ◽  
Wolfgang Bäumer
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Allergic Inflammation ◽  
Receptor Activation ◽  
Histamine H4 Receptor ◽  
Killer Cells ◽  
H4 Receptor

Effect of Chicoric Acid on Mast Cell-Mediated Allergic Inflammation in Vitro and in Vivo

2015 ◽  
Vol 78 (12) ◽  
pp. 2956-2962 ◽  
Author(s):  
Na Young Lee ◽  
Kyung-Sook Chung ◽  
Jong Sik Jin ◽  
Keuk Soo Bang ◽  
Ye-Jin Eom ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Inflammation ◽  
Chicoric Acid

scholarly journals MiR-154-5p-MCP1 Axis Regulates Allergic Inflammation by Mediating Cellular Interactions

2021 ◽  
Vol 12 ◽  
Author(s):  
Misun Kim ◽  
Hyein Jo ◽  
Yoojung Kwon ◽  
Myeong Seon Jeong ◽  
Hyun Suk Jung ◽  
...  
Keyword(s):  
Allergic Inflammation ◽  
Passive Cutaneous Anaphylaxis ◽  
Allergic Reactions ◽  
Dependent Manner ◽  
Cellular Interactions ◽  
Array Analysis ◽  
Molecular Features ◽  
Rat Basophilic Leukemia Cells

In a previous study, we have demonstrated that p62, a selective receptor of autophagy, can regulate allergic inflammation. In the present study, microRNA array analysis showed that miR-154-5p was increased by antigen (DNP-HSA) in a p62-dependent manner in rat basophilic leukemia cells (RBL2H3). NF-kB directly increased the expression of miR-154-5p. miR-154-5p mediated in vivo allergic reactions, including passive cutaneous anaphylaxis and passive systemic anaphylaxis. Cytokine array analysis showed that antigen stimulation increased the expression of MCP1 in RBL2H3 cells in an miR-154-5p-dependent manner. Reactive oxygen species (ROS)-ERK-NF-kB signaling increased the expression of MCP1 in antigen-stimulated RBL2H3 cells. Recombinant MCP1 protein induced molecular features of allergic reactions both in vitro and in vivo. Anaphylaxis-promoted tumorigenic potential has been known to be accompanied by cellular interactions involving mast cells, and macrophages, and cancer cells. Our experiments employing culture medium, co-cultures, and recombinant MCP1 protein showed that miR-154 and MCP1 mediated these cellular interactions. MiR-154-5p and MCP1 were found to be present in exosomes of RBL2H3 cells. Exosomes from PSA-activated BALB/C mouse induced molecular features of passive cutaneous anaphylaxis in an miR-154-5p-dependent manner. Exosomes from antigen-stimulated RBL2H3 cells enhanced both tumorigenic and metastatic potentials of B16F1 melanoma cells in an miR-154-5p-dependent manner. Exosomes regulated both ROS level and ROS mediated cellular interactions during allergic inflammation. Our results indicate that the miR-154-5p-MCP1 axis might serve as a valuable target for the development of anti-allergy therapeutics.

In vivo hydroquinone (HQ) exposure impairs macrophage function and lung allergic inflammation

2009 ◽  
Vol 189 ◽  
pp. S174
Author(s):  
Cristina Bichels Hebeda ◽  
Sandra M.D. Macedo ◽  
Daniele M.H. Cavalcanti ◽  
Jorge M.C. Ferreira ◽  
Gloria T. Souza ◽  
...  
Keyword(s):  
Allergic Inflammation ◽  
Macrophage Function

scholarly journals Human tissue mast cells are an inducible reservoir of persistent HIV infection

Blood ◽  
2007 ◽  
Vol 109 (12) ◽  
pp. 5293-5300 ◽  
Author(s):  
J. Bruce Sundstrom ◽  
Jane E. Ellis ◽  
Gregory A. Hair ◽  
Arnold S. Kirshenbaum ◽  
Dean D. Metcalfe ◽  
...  
Keyword(s):  
Mast Cells ◽  
Highly Active Antiretroviral Therapy ◽  
Mononuclear Cells ◽  
Tissue Injury ◽  
Allergic Inflammation ◽  
Placental Tissue ◽  
Latently Infected ◽  
Tissue Compartments

AbstractWe have proposed that, unlike other HIV-vulnerable cell lineages, progenitor mast cells (prMCs), cultured in vitro from undifferentiated bone marrow–derived CD34+ pluripotent progenitors (PPPs), are susceptible to infection during a limited period of their ontogeny. As infected prMCs mature in culture, they lose expression of viral chemokine coreceptors necessary for viral entry and develop into long-lived, latently infected mature tissue mast cells (MCs), resistant to new infection. In vivo recruitment of prMCs to different tissue compartments occurs in response to tissue injury, growth, and remodeling or allergic inflammation, allowing populations of circulating and potentially HIV-susceptible prMCs to spread persistent infection to diverse tissue compartments. In this report, we provide in vivo evidence to confirm this model by demonstrating that HIV-infected women have both circulating prMCs and placental tissue MCs (PLMCs) that harbor inducible infectious HIV even after highly active antiretroviral therapy (HAART) during pregnancy. Furthermore, infectious virus, capable of infecting alloactivated fetal cord blood mononuclear cells (CBMCs), could be induced in isolated latently infected PLMCs after weeks in culture in vitro. These data provide the first in vivo evidence that tissue MCs, developed from infected circulating prMCs, comprise a long-lived inducible reservoir of persistent HIV in infected persons during HAART.

Chronic Allergic Inflammation Induces Replication of Airway Smooth Muscle Cells In Vivo in Guinea Pigs

CHEST Journal ◽  
1995 ◽  
Vol 107 (3) ◽  
pp. 93S ◽  
Author(s):  
Tony R. Bai ◽  
Zang-Ling Wang ◽  
Blair Walker ◽  
Peter D. Paré
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Guinea Pigs ◽  
Allergic Inflammation ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells

scholarly journals Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation

2005 ◽  
Vol 77 (5) ◽  
pp. 800-810 ◽  
Author(s):  
Vanessa Pinho ◽  
Danielle G. Souza ◽  
Michele M. Barsante ◽  
Fabiana P. Hamer ◽  
Marta S. De Freitas ◽  
...  
Keyword(s):  
Allergic Inflammation

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

10.3791/59043 ◽  
2019 ◽  
Author(s):  
Anja Schulz-Kuhnt ◽  
Sebastian Zundler ◽  
Anika Grüneboom ◽  
Clemens Neufert ◽  
Stefan Wirtz ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Allergic Inflammation ◽  
Light Sheet ◽  
In Vivo Model ◽  
Advanced Imaging ◽  
Light Sheet Microscopy
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