scholarly journals Novel sGC activators increase glomerular cGMP, induce vasodilation, and improve blood flow in the murine kidney

Author(s):  
Daniel Stehle ◽  
Min Ze Xu ◽  
Tibor Schomber ◽  
Michael G. Hahn ◽  
Frank Schweda ◽  
...  
2016 ◽  
pp. 22-25
Author(s):  
N. A. Lomova ◽  
N. V. Dubrovina ◽  
I. E. Dragun ◽  
E. S. Tolstopyatova

Hemorrhoids is one of the most common diseases during pregnancy and in the postpartum period. It can be acute and chronic, and manifests itself in the form of thrombosis, inflammation or bleeding. The course of the disease can be either chronic or acute. Acute hemorrhoids is a complication of the chronic process and is further subdivided into forms according to the severity of inflammation and thrombosis. The classification reflects the pathogenesis of hemorrhoids; it is convenient and practical allowing for an unbiased approach in outlining indications and selecting the desired method of treatment depending on the stage of the disease and its severity. Conservative treatment of acute and chronic hemorrhoids is aimed at relief of symptoms of acute hemorrhoids, preventing complications as well as exacerbations of the chronic disease. Medications used in the treatment have anti-inflammatory, analgesic, hemostatic effects, improve blood flow and blood circulation in cavernous formations. The article tells about the drug of choice in the treatment of hemorrhoids in pregnant and postpartum women.


1964 ◽  
Vol 2 (6) ◽  
pp. 22-24

Many drugs are claimed to be effective vasodilators which can improve blood flow in peripheral vascular disorders. Among them are noradrenaline antagonists such as tolazoline (Priscol - Ciba), azapetine (Ilidar - Roche) and phenoxybenzamine (Dibenyline - SKF), and drugs which act directly on the smooth muscle of blood vessels, such as isoxsuprine (Duvadilan - Crookes; Dilavase - Organon), nicotinyl alcohol (Ronicol - Roche), and cyclandelate (Cyclospasmol - Camden). Nicotinic acid, papaverine and ethyl alcohol are also used as vasodilators. Claims that cyclandelate and certain other drugs are indicated in the treatment of cerebrovascular disease will be discussed in a future issue.


Transfusion ◽  
1998 ◽  
Vol 38 (7) ◽  
pp. 703-703 ◽  
Author(s):  
J Kane ◽  
S Dzik

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Dika Ashrinda ◽  
Refli Hasan ◽  
Cut Aryfa Andra ◽  
Zulfikri Muhtar ◽  
Harris Hasan

STEMI with onset≤12 hours, necessary to take Primary Percutaneous Coronary Intervention (pPCI), but if there is no facility, another therapy is fibrinolytic, to improve blood flow in the coronary artery and myocardial function, thus reducing infarction expansion. This is a retrospective study in STEMI patients onset≤12 hours, had performed successful fibrinolytic with Streptokinase (SK) and Alteplase (tPA) from January 2015 to August 2017. TIMI flow was assessed by coronary angiography. There were 54 patients who had performed successful fibrinolytic therapy with SK and tPA; each group had 27 patients. In the SK group, there were nine patients (33.3%) with TIMI flow 2 and 18 patients (66.7%) with TIMI flow 3. While in the tPA group there were 11 patients (40.7%) with TIMI flow 2, 16 patients (59.3%) with TIMI flow 3, (p=0.573). There is no difference in TIMI flow between SK and tPA on STEMI patients after success fibrinolytic therapy.


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