scholarly journals Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells

2021 ◽  
Author(s):  
Kazutoshi Toriyama ◽  
Naoharu Takano ◽  
Hiroko Kokuba ◽  
Hiromi Kazama ◽  
Shota Moriya ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lung Cancer Cells ◽  
Lysosomal Membrane Permeabilization

Abstract 3511: Chloroquine-induced lysosomal membrane permeabilization restores sensitivity to cisplatin in refractory lung cancer cells

2016 ◽  
Author(s):  
Magdalena Circu ◽  
James Cardelli ◽  
Glenn Mills ◽  
Martin Barr ◽  
Hazem E. El-Osta
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lung Cancer Cells ◽  
Lysosomal Membrane Permeabilization

Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition

2021 ◽  
Author(s):  
Minho Won ◽  
Sunkyung Choi ◽  
Seonghye Cheon ◽  
Eun-Mi Kim ◽  
Taeg Kyu Kwon ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Autophagic Flux ◽  
Lysosomal Membrane Permeabilization

Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au–ZnO hybrid nanoparticles

2014 ◽  
Vol 50 (60) ◽  
pp. 8117 ◽  
Author(s):  
Wen Gao ◽  
Wenhua Cao ◽  
Huaibin Zhang ◽  
Ping Li ◽  
Kehua Xu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Hybrid Nanoparticles ◽  
Lysosomal Membrane Permeabilization ◽  
Apoptosis In Cancer Cells

scholarly journals Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184922 ◽  
Author(s):  
Magdalena Circu ◽  
James Cardelli ◽  
Martin Barr ◽  
Kenneth O’Byrne ◽  
Glenn Mills ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Membrane Permeabilization ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Lysosomal Function ◽  
Lysosome Membrane

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

2018 ◽  
Vol 46 (2) ◽  
pp. 207-215 ◽  
Author(s):  
Ana Serrano-Puebla ◽  
Patricia Boya
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Proteolytic Enzymes ◽  
Hydrolytic Enzymes ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lysosomal Membrane Permeabilization ◽  
Regulated Cell Death ◽  
Cathepsin Activity ◽  
Intracellular Cascades

Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the intracellular degradation of macromolecules. Damage of these organelles often results in lysosomal membrane permeabilization (LMP) and the release into the cytoplasm of the soluble lysosomal contents, which include proteolytic enzymes of the cathepsin family. This, in turn, activates several intracellular cascades that promote a type of regulated cell death, called lysosome-dependent cell death (LDCD). LDCD can be inhibited by pharmacological or genetic blockade of cathepsin activity, or by protecting the lysosomal membrane, thereby stabilizing the organelle. Lysosomal alterations are common in cancer cells and may increase the sensitivity of these cells to agents that promote LMP. In this review, we summarize recent findings supporting the use of LDCD as a means of killing cancer cells.

scholarly journals Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization

Oncotarget ◽  
2017 ◽  
Vol 8 (16) ◽  
pp. 26992-27006 ◽  
Author(s):  
Long-Xian Lv ◽  
Zhen-Xing Zhou ◽  
Zhan Zhou ◽  
Li-Jiang Zhang ◽  
Ren Yan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Tubulin Polymerization ◽  
Gastric Cancer Cells ◽  
Lysosomal Membrane Permeabilization

A facile composite nanoparticle promoted by photoelectron transfer and consumption for tumor combination therapy

2020 ◽  
Vol 4 (10) ◽  
pp. 3047-3056
Author(s):  
Yahui Zhang ◽  
Weizhou Sha ◽  
Yang Liu ◽  
Wei Wang ◽  
Zhi Yuan
Keyword(s):  
Membrane Potential ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Mitochondrial Membrane Potential ◽  
Mitochondrial Membrane ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lysosomal Membrane Permeabilization ◽  
Composite Nanoparticle ◽  
Mitochondrial Death Pathway

BTCu NPs can cause significant lysosomal membrane permeabilization (LMP) and mitochondrial membrane potential depolarization, thus indicating a lysosomal–mitochondrial death pathway in cancer cells.

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