In this study, a novel combined therapy of nano-cryosurgery and RF induced nano-hyperthermia was proposed, with the purpose of improving tumor treatment efficacy. To better understand the mechanisms of enhancement on freezing and heating by introducing magnetic nanoparticles with high thermal conductivity during the combined therapy of nano-cryosurgery and RF hyperthermia, a series of numerical investigations were performed. The results indicate that the combined therapy of nano-cryosurgery and RF hyperthermia can serve as an applicable way to flexibly control the size and shape of lethal freezing/heating areas, which will help selectively ablate the target tissue and then optimize the thermal treatment process for tumor.
WEE1i and ATRi trigger STING‐dependent immune response and enhance tumor treatment efficacy through PD‐L1 blockade
