scholarly journals Recurrent PTPRZ1‐MET fusion and a high occurrence rate of MET exon 14 skipping in brain metastases

2021 ◽  
Author(s):  
Rui‐Chao Chai ◽  
Xing Liu ◽  
Bo Pang ◽  
Yu‐Qing Liu ◽  
Jing‐Jun Li ◽  
...  
2004 ◽  
Vol 202 ◽  
pp. 20-28
Author(s):  
Geoffrey W. Marcy ◽  
Debra A. Fischer ◽  
R. Paul Butler ◽  
Steven S. Vogt

The Doppler residuals to the Keplerian fits for extrasolar planets reveal important properties of the planets and host stars. Stellar magnetic fields modify the photospheric velocity fields, causing Doppler fluctuations with unknown time scales. This Doppler “jitter”, seen prominently in the magnetic stars Epsilon Eridani and ξ Boo A, compromises the detectability of planets. The Doppler residuals during the transit of HD209458 reveal that the planet orbits in the same direction as the star spins. Moreover, the transit path across the star is nearly parallel to the stellar equator. Most interestingly, the Doppler residuals of known planets often reveal additional coherent variations, probably caused by additional companions. Both 55 Cancri and HD168443 reveal such coherent Doppler residuals. Another five planet–bearing stars observed at Lick show trends in the Doppler residuals indicating the presence of additional companions. Remarkably, about half of the known extrasolar planets reveal such coherent variations. This suggests that stars with planets have a high occurrence rate of harboring more distant companions, planetary or otherwise.


2010 ◽  
Vol 19 (3) ◽  
pp. 225-226 ◽  
Author(s):  
Peter Wostyn ◽  
Kurt Audenaert ◽  
Peter Paul De Deyn

2002 ◽  
Vol 47 (3) ◽  
pp. 165-168 ◽  
Author(s):  
A.U. Bayer ◽  
F. Ferrari ◽  
C. Erb

2020 ◽  
Vol 52 (4) ◽  
Author(s):  
Tasbihullah Tasbihullah ◽  
Sadeeq ur Rahman ◽  
Tariq Ali ◽  
Umer Saddique ◽  
Shakoor Ahmad ◽  
...  

2021 ◽  
Author(s):  
Guobao Xu ◽  
Meko Matthew ◽  
Lara Klippel ◽  
Isabel Dorado-Liñán ◽  
Valerie Trouet

<p><strong>The jet stream configuration over the Atlantic Ocean and the European </strong><strong>continent</strong><strong> substantially affects climatic extremes in Western Eurasia by transporting heat and vorticity</strong><strong>. </strong><strong>However, how the Europe-Atlantic jet configuration varies and how it affects European climate on the long time-scales are still unclear. We compiled a network of tree-ring width, blue intensity, and maximum density chronologies from Europe to explore past variability in the summer Europe-Atlantic Jet stream and its influence on regional climate. By combining five regional chronologies, we were able to reconstruct July-August jet stream latitude (JSL) PC2 variability over the past millennium (978-2010 CE) for the Europe-Atlantic domain (30°W to 40°E). Our reconstruction explains 40% of summer JSL PC2 variability over the instrumental period (1948-2010 CE) with strong skill. Our millennial-long reconstruction shows that summer JSL is a relevant driver of the temperature, precipitation, and drought dipoles observed between Northwestern and Southern Europe. Positive summer JSL PC2 values (northward jet position) generally lead to a strengthening of the European summer climate dipole, while negative values (southward jet position) lead to a weak or insignificant dipole mode. Our summer JSL reconstruction shows large variability and a high occurrence rate of extremes over the 20<sup>th</sup> century, as well as 1200-1350 CE Medieval Climate Anomaly (MCA). The high occurrence rate of summer JSL extremes corresponds to periods with increased number of climatic extremes. Our results suggest that the summer JSL contributes to the European climate dipole both in a long-term context and in its extremes. We also reveal that the occurrence rate of summer JSL extremes is double during the 20<sup>th</sup> century compared to other periods, especially for the negative extremes, which might be related to anthropogenic warming. Our results suggest a high occurrence rate of summer JSL extremes during the 20<sup>th</sup> century, leading to more climatic extremes in Europe, as well as a prevailing northward summer JSL position resulting in a weakening climatic dipole.</strong></p>


2016 ◽  
Vol 13 (12) ◽  
pp. 656-660 ◽  
Author(s):  
Young-Ji Kim ◽  
Hong-Seok Kim ◽  
Kwang-Yeop Kim ◽  
Jung-Whan Chon ◽  
Dong-Hyeon Kim ◽  
...  

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Wei-hai Xu ◽  
Huisheng Chen ◽  
Yi Yang ◽  
Jun Xu ◽  
Meng Zhang ◽  
...  

Background: Pathology studies suggested obstruction of the origins of penetrating arteries by parent intracranial artery plaque can cause an infarct. Using high-resolution magnetic resonance imaging(HRMRI), intracranial plaque distribution can be identified in vivo. We aimed to investigate the occurrence rate of parent intracranial artery plaque in patients with acute penetrating artery territory infarcts. Methods: Patients with first ever stroke within 72 hours from onset, confirmed by diffusion weighted imaging, were recruited from 16 medical centers. Conventional magnetic resonance imaging (MRI), magnetic resonance angiography, HRMRI (including 3-dimentional T1 images and 2-dimentional T2 images) and susceptibility-weighted imaging were performed. All patients received thorough evaluations to determine the cause of stroke according to TOAST classifications. A plaque was identified if there was eccentric wall thickening, whereas the thinnest part was estimated to be less than 50% of the thickest point by visual inspection. The plaques within middle cerebral artery(MCA) were further classified based on their orientation being centered on the superior, inferior, dorsal, or ventral side of the vessel. Possible culprit plaques were defined if superior and/or dorsal MCA plaques ipsilateral to the infarcts were observed. The plaques within basilar artery were further classified based on their orientation being centered on the ventral, dorsal, or lateral sides of the vessel ( ipsilateral to infarcts, or contralateral to infarcts). Possible culprit plaques were defined if dorsal plaques or the plaques ipsilateral to brain stem infarcts were observed. Results: Six hundred and one patients (70% male, mean age 61±16 years old, mean NIHSS 6± 5) were enrolled. Two hundred and eighty-eight(48%) patients were diagnosed with penetrating artery territory infarcts. Of them, 139 patients(48%, 85 MCAs and 54 BAs) had a plaque within the parent intracranial artery of the infarcts. Most of the parent artery plaques(119,85%) were identified as possible culprit plaques. Conclusions: High occurrence rate of parent intracranial artery plaques was observed in patients with acute penetrating artery territory infarcts.


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