Preparation, characterization, and in vivo study of rhein solid lipid nanoparticles for oral delivery

2017 ◽  
Vol 90 (5) ◽  
pp. 867-872 ◽  
Author(s):  
Haiyang Feng ◽  
Yuping Zhu ◽  
Zhixuan Fu ◽  
Dechuan Li
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Solid Lipid

Transdermal Delivery of Curcumin-Loaded Solid Lipid Nanoparticles as Microneedle Patch: an In Vitro and In Vivo Study

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Ankitha Prabhu ◽  
Jobin Jose ◽  
Lalit Kumar ◽  
S Salwa ◽  
M Vijay Kumar ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Solid Lipid ◽  
Microneedle Patch

Lacidipine Loaded Solid Lipid Nanoparticles for Oral Delivery: Preparation, Characterization and In vivo Evaluation

2016 ◽  
Vol 9 (6) ◽  
pp. 3524-3530 ◽  
Author(s):  
Kishan V. ◽  
Sandeep V ◽  
Narendar D ◽  
Arjun N
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Pharmacokinetic Studies ◽  
Electron Microscopic ◽  
In Vivo Evaluation ◽  
Solid Lipid

The objective of this study was to develop and evaluate lacidipine (LD) loaded solid lipid nanoparticles (LD-SLNs) for improving the oral bioavailability. LD-SLNs were prepared in two steps. First step was hot homogenization and next by ultrasonication method, using triglycerides (tripalmitin and tristearin), monoglyceride and surfactants (Poloxamer 188 and egg lecithin E80). The prepared LD-SLNs were characterized for particle size, PDI, zeta potential, drug content, entrapment efficiency (EE %).         In vitro drug release studies using a dialysis bag method in 0.1N HCl and pH 6.8 phosphate buffer were conducted. In addition, long-term physical stability of the optimized SLNs was investigated at refrigerated and room temperature for 60 days. FTIR and DSC studies revealed that no interaction between the drug and lipids. LD-SLNs prepared with Dynasan-116 (F3), having the size of 141.86nm, PDI of 0.293, ZP of -22.3 m with 94.75% of EE was optimized and was stable for 60days. Scanning electron microscopic studies showed nearly spherical shaped particles. Further, pharmacokinetic studies were conducted in wistar rats. The relative bioavailability of LD in SLNs was 2.03 times when compared with that of the LD suspension. The results are indicative of SLNs as suitable lipid based carrier system for improving the oral bioavailability of LD. 

In Vitro and in Vivo Study of Two Types of Long-Circulating Solid Lipid Nanoparticles Containing Paclitaxel

2001 ◽  
Vol 49 (11) ◽  
pp. 1444-1447 ◽  
Author(s):  
Da-Bing CHEN ◽  
Tian-zhi YANG ◽  
Wang-Liang LU ◽  
Qiang ZHANG
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Solid Lipid

Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study

2020 ◽  
Vol 188 ◽  
pp. 110749 ◽  
Author(s):  
Valquíria T. Arantes ◽  
André A.G. Faraco ◽  
Frederico B. Ferreira ◽  
Cleida A. Oliveira ◽  
Elisângela Martins-Santos ◽  
...  
Keyword(s):  
Wound Healing ◽  
Retinoic Acid ◽  
Solid Lipid Nanoparticles ◽  
Chitosan Film ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Diabetic Wound ◽  
Solid Lipid ◽  
Diabetic Wound Healing

scholarly journals FORMULATION AND QBD BASED OPTIMIZATION OF METHOTREXATE-LOADED SOLID LIPID NANOPARTICLES FOR AN EFFECTIVE ANTI-CANCER TREATMENT

2021 ◽  
pp. 132-143
Author(s):  
CHAITALI SURVE ◽  
RUCHI SINGH ◽  
ANANYA BANERJEE ◽  
SRINIVAS PATNAIK ◽  
SUPRIYA SHIDHAYE
Keyword(s):  
Particle Size ◽  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Polydispersity Index ◽  
In Vivo Studies ◽  
Solid Lipid

Objective: In the current study, the Quality by Design method was utilized for the formulation of solid lipid nanoparticles of Methotrexate (MTX SLNs). Methods: MTX SLNs formulated by melt emulsification method were studied for the effect of independent variables viz. concentration of lipid and surfactants on quality attributes viz. particle size, polydispersity index, and entrapment efficiency of SLNs using 32 factorial design. Results: The optimal formulation was spherical, had a particle size of 147.6±4.1 nm (z-average), a polydispersity index of 0.296±0.058, a zeta potential of −19±0.98 mV, encapsulation efficiency of 98.7±1.55%, and a cumulative drug release of 95.59±0.918% in 5 h. Conclusion: The  in vitro and in vivo studies revealed that SLNs provide a promising oral delivery system to improve the bioavailability of MTX.

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