Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model

2020 ◽  
Author(s):  
Kyung Hee Park ◽  
Eun Yi Oh ◽  
Heejae Han ◽  
Jung Dong Kim ◽  
Sung Jin Kim ◽  
...  
Keyword(s):  
Asthma Model ◽  
Murine Asthma Model

scholarly journals The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway

2020 ◽  
Author(s):  
Yingjie Zhu ◽  
Jingjing Luo ◽  
You Xu ◽  
Shucheng Hua ◽  
Dan Li ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Active Compound ◽  
Protective Role ◽  
Asthma Model ◽  
Common Illnesses ◽  
Murine Asthma Model ◽  
Chronic Airway

Asthma is one of the most common illnesses associated with chronic airway inflammation; however, there are currently no effective therapies apart from glucocorticoids. Zingerone (ZIN), an active compound isolated from...

Astragalus membranaceus modulates Th1/2 immune balance and activates PPARγ in a murine asthma model

2014 ◽  
Vol 92 (5) ◽  
pp. 397-405 ◽  
Author(s):  
Shih-Ming Chen ◽  
Yau-Sheng Tsai ◽  
Su-Wen Lee ◽  
Ya-Hui Liu ◽  
Shuen-Kuei Liao ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Chinese Herb ◽  
A549 Cells ◽  
Nuclear Hormone Receptor ◽  
Astragalus Membranaceus ◽  
Luciferase Reporter ◽  
Mrna Levels ◽  
Th2 Cytokines ◽  
Asthma Model ◽  
Murine Asthma Model

Astragalus membranaceus, a traditional Chinese herb, has been used to improve airway inflammation and asthma. The present study investigated whether A. membranaceus has immunotherapeutic effects on asthma, a chronic inflammatory mucosal disease that is associated with excess production of IgE, eosinophilia, T helper 2 (Th2) cytokines, and bronchial hyperresponsiveness. An ovalbumin (OVA)-induced, chronic inflammatory airway murine asthma model was used to examine the status of pulmonary inflammation after the administration of A. membranaceus. The IgE levels in serum and bronchoalveolar lavage fluid showed a tendency to decrease after the administration of A. membranaceus. The number of eosinophils decreased and infiltration of inflammatory cells and collagen deposition declined in lung sections after A. membranaceus administration. The RNA and protein levels of Th2 cytokines and the ratio of the GATA3/T-bet mRNA levels decreased after A. membranaceus treatment. Furthermore, the mRNA level of peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor, increased in the lung tissues of A. membranaceus–treated mice. Finally, an A. membranaceus water extract activated PPARγ activity in either human embryonic kidney 293 (HEK293) or A549 cells in a PPARγ-responsive element-containing luciferase reporter assay. These results indicate that A. membranaceus has an inhibitory effect on airway inflammation in a murine model of asthma through modulating the imbalanced relationship between Th1 and Th2 cytokines.

scholarly journals Effects of sublingual immunotherapy in a murine asthma model sensitized by intranasal administration of house dust mite extracts

2017 ◽  
Vol 66 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Kenjiro Shima ◽  
Toshiyuki Koya ◽  
Keisuke Tsukioka ◽  
Takuro Sakagami ◽  
Takashi Hasegawa ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Intranasal Administration ◽  
Sublingual Immunotherapy ◽  
Asthma Model ◽  
Dust Mite ◽  
Murine Asthma Model

scholarly journals Mechanisims of asthma and allergic disease – 1093. A novel human anti-VCAM-1 Monoclonal antibody Ameliorates airway inflammation and remodeling in murine asthma model

2013 ◽  
Vol 6 ◽  
pp. P89
Author(s):  
Jae-Hyun Lee ◽  
Jung-Ho Sohn ◽  
Su Yeon Ryu ◽  
Kyung D Moon ◽  
Chein-Soo Hong ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Airway Inflammation ◽  
Allergic Disease ◽  
Asthma Model ◽  
Murine Asthma Model

scholarly journals Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ahmed Z. El-Hashim ◽  
Maitham A. Khajah ◽  
Waleed M. Renno ◽  
Rhema S. Babyson ◽  
Mohib Uddin ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Egfr Transactivation ◽  
Downstream Signaling ◽  
Asthma Model ◽  
Murine Asthma Model

Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model

2011 ◽  
Vol 150 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Yu Jin Oh ◽  
Jangwook Lee ◽  
Ji Young Seo ◽  
Taiyoun Rhim ◽  
Sang-Heon Kim ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Asthma Model ◽  
Plga Microparticles ◽  
Murine Asthma Model

Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model

Allergy ◽  
2017 ◽  
Vol 73 (2) ◽  
pp. 416-420 ◽  
Author(s):  
M. Asaduzzaman ◽  
C. Davidson ◽  
D. Nahirney ◽  
Y. Fiteih ◽  
L. Puttagunta ◽  
...  
Keyword(s):  
Asthma Model ◽  
Murine Asthma Model
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