scholarly journals Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing

2018 ◽  
Vol 192 (3) ◽  
pp. 259-270 ◽  
Author(s):  
L. A. Aqrawi ◽  
M. Ivanchenko ◽  
A. Björk ◽  
J. I. Ramírez Sepúlveda ◽  
J. Imgenberg-Kreuz ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Cxcr5 Expression ◽  
Sjögren‘S Syndrome

scholarly journals Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in sjögren's syndrome

1982 ◽  
Vol 25 (4) ◽  
pp. 419-426 ◽  
Author(s):  
Robert I. Fox ◽  
Scott A. Carstens ◽  
Sherman Fong ◽  
Charles A. Robinson ◽  
Frank Howell ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

Analysis of Peripheral Blood and Salivary Gland Lymphocytes in Sjogren’s Syndrome

1983 ◽  
pp. 290-290
Author(s):  
Robert Fox ◽  
Sherman Fong ◽  
Samuel Behar ◽  
Charles Robinson ◽  
Francis Howell ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

Characterization of peripheral blood and salivary gland lymphocytes in Sjögren's syndrome

1990 ◽  
Vol 69 (5) ◽  
pp. 572-577 ◽  
Author(s):  
Haviye Çelenligil ◽  
Emin Kansu ◽  
Şevket Ruacan ◽  
Kenan Eratalay ◽  
Murat Irkeç
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

Quantitative Bacteriology of the Parotid Salivary Gland in Health and Sjogren's Syndrome

1993 ◽  
Vol 6 (1) ◽  
Author(s):  
M. A. O. Lewis ◽  
T. W. MacFarlane ◽  
P-J. Lamey ◽  
R. E. Leishman ◽  
N. M. Howie
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Parotid Salivary Gland ◽  
Sjögren‘S Syndrome

scholarly journals AB0017 IMMUNE CHARACTERISTICS OF PERIPHERAL BLOOD IN SECONDARY SJOGREN’S SYNDROME PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1043.1-1043
Author(s):  
R. Su ◽  
Y. Y. Wang ◽  
C. Wang
Keyword(s):  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Absolute Number ◽  
Sjogren's Syndrome ◽  
Secondary Sjögren’S Syndrome ◽  
T Subsets ◽  
Secondary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Background:Secondary Sjogren’s Syndrome (sSS) is diagnosed when symptoms of SS coexist with other systemic connective tissue disease, often secondary to rheumatoid arthritis(RA).The occurrence of SS secondary with RA will worsen the course of disease and increase the high incidence and mortality of RA. At present, the immune characteristics of peripheral blood of sSS with RA are not clear.Objectives:To observe the difference of immune Immune characteristics in peripheral blood between sSS secondary to RA, primary Sjogren’s syndrome(pSS) and RA patients.Methods:20 sSS with RA patients, 20 pSS paients and 20 RA pateints hospitalized in ShanXi medical university the second Hospital were enrolled. The percentage and absolute numbers of lymphocyte phenotypes and CD4+ T subsets in peripheral blood were examined by flow cytometry.Results:As for the percentage and absolute number of total T, B, NK, CD4+T,CD8+ T and the ratio of CD4 + T to CD8+ T cells, there was no significant difference between the sSS with RA, RA, and SS group. There was also no statistical difference in the percentage of CD4+T subsets(Th1,Th2,Th17 and Treg) between the three groups. But the ratio of Th17 and Treg in sSS with RA group was increased than pSS group.About comparison of absolute number of CD4+T subsets, there was no statistical difference among the three groups except that the Th1 cells in RA group was significantly higher than SS group.Conclusion:Elevated Th17/Treg may be an immunological feature that differentiates sSS with RA patients from pSS patients. In addition, in general, peripheral blood of patients with RA and SS have similar immune characteristics.References:[1]Wei W,Ahmad S S, Chi S. From Molecular Mechanism to the Etiology of Sjogren Syndrome.Curr Pharm Des. 2018;24(35):4177-4185.[2]Hajiabbasi A, Masooleh I S,Alizadeh Y, Secondary Sjogren’s Syndrome in 83 Patients With Rheumatoid Arthritis.Acta Med Iran.2016;54(7):448-53.Figure 1.The comparsion about the lymphocyte phenotypes and CD4+ T subsets in peripheral blood of sSS with RA(n=20), pSS(n=20) and RA patients(n=20).(*p<0.05,**p<0.001,*p<0.0001)Disclosure of Interests:None declared

Comparison of parotid and minor salivary gland biopsy specimens in the diagnosis of sjögren's syndrome

1988 ◽  
Vol 31 (5) ◽  
pp. 662-666 ◽  
Author(s):  
Christopher M. Wise ◽  
Carlos A. Agudelo ◽  
Elliott L. Semble ◽  
Thomas E. Stump ◽  
Ralph D. Woodruff
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Minor Salivary Gland ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Minor Salivary Gland Biopsy ◽  
Biopsy Specimens ◽  
Salivary Gland Biopsy ◽  
Sjögren‘S Syndrome

Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome

2009 ◽  
Vol 69 (6) ◽  
pp. 1235-1238 ◽  
Author(s):  
Petra Vogelsang ◽  
Johan G Brun ◽  
Gunnvor Øijordsbakken ◽  
Kathrine Skarstein ◽  
Roland Jonsson ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Healthy Controls ◽  
Myeloid Dendritic Cells ◽  
Antigen Presenting ◽  
Sjögren‘S Syndrome

ObjectiveSjögren's syndrome (SS) is a lymphoproliferative autoimmune disease, characterised by dryness of the mouth and eyes. Dendritic cells (DC) are potent antigen-presenting cells crucial for initiating and maintaining primary immune responses. This study quantified interferon-producing plasmacytoid DC (pDC) and two myeloid DC subsets (mDC1 and mDC2) in peripheral blood (PB) from primary SS (pSS) patients and healthy controls.MethodsBlood samples from 31 pSS patients and 28 gender and age-matched healthy controls were analysed by flow cytometry using the Miltenyi Blood DC enumeration kit. The presence of pDC in salivary glands (SG) from pSS patients was analysed by immunohistochemistry.ResultsPatients with pSS had significantly less pDC and mDC2 in PB compared with healthy controls. Moreover, pDC are present in SG from patients with pSS.ConclusionPatients with pSS have alterations among DC populations in PB, and pDC are present in the SG, suggesting a potential role of these cells in SS.

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