Vitamin D has received worldwide attention not only for its importance for bone health in children and adults but also for reducing risk of many
chronic diseases including autoimmune diseases, type 2 diabetes, heart disease, infectious diseases and cancers. The active form of vitamin D,
1,25-dihydroxyvitamin D3, has been shown to regulate the transcription and function of genes associated with placental invasion, normal
implantation and angiogenesis.This nested case control study was done to nd the association between early pregnancy maternal vitamin D level
and adverse pregnancy outcome in terms of development of gestational hpertention, gestaional diabetes mellitus, fetal growth restriction and
preterm labour In our study 68 of 78 subjects (87.13%) were found to be vitamin D decient at a cutoff value of 25(OH)D level of <22.5 hg/ml . The
mean 25(OH)D level in case group was 12.96±6.38 hg /ml, which is lower than the mean 25(OH)D level of 16.14±7.98 hg/ml among the control
group(p value-0.025). Prevalence of severe vitamin D deciency in case group was 43.6% of compared to 12.8% control group (<10ng/ml) hence
severe vitamin D deciency before 20 weeks of gestation increases the risk of development of adverse outcome by 5 fold (OR- 4.94, CI 1.44-
19.35).hence early pregnancy low vitamin D status increases the risk of adverse pregnancy outcome in study population.
The relationship between maternal vitamin D deficiency and glycolipid metabolism and adverse pregnancy outcome