scholarly journals Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease

2017 ◽  
Vol 23 (11) ◽  
pp. 885-893 ◽  
Author(s):  
Ting-Ting Liu ◽  
Xiao-Lian Ye ◽  
Jin-Ping Zhang ◽  
Ting-Ting Yu ◽  
Shan-Shan Cheng ◽  
...  
Keyword(s):  
Mouse Model ◽  
Neurodegenerative Disease ◽  
Adult Neurogenesis ◽  
Neuron Loss ◽  
Reactive Astrocytosis

Presymptomatic motor neuron loss and reactive astrocytosis in the SOD1 mouse model of amyotrophic lateral sclerosis

2001 ◽  
Vol 24 (11) ◽  
pp. 1510-1519 ◽  
Author(s):  
Sandra J. Feeney ◽  
Penelope A. McKelvie ◽  
Lawrence Austin ◽  
M.J. Bernadette Jean-Francois ◽  
Robert Kapsa ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Motor Neuron ◽  
Neuron Loss ◽  
Motor Neuron Loss ◽  
Sod1 Mouse ◽  
Lateral Sclerosis ◽  
Reactive Astrocytosis

Adult neurogenesis and neurodegenerative disease

2006 ◽  
Vol 1 (1) ◽  
pp. 15-28 ◽  
Author(s):  
Barbara Steiner ◽  
Susanne A Wolf ◽  
Gerd Kempermann
Keyword(s):  
Neurodegenerative Disease ◽  
Adult Neurogenesis

scholarly journals Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76497 ◽  
Author(s):  
Alice Krezymon ◽  
Kevin Richetin ◽  
Hélène Halley ◽  
Laurent Roybon ◽  
Jean-Michel Lassalle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Adult Neurogenesis ◽  
Tg2576 Mouse ◽  
Model Of Alzheimer’S Disease

Adult neurogenesis is altered in neurodegenerative disease

2021 ◽  
Vol 24 (12) ◽  
pp. 1640-1640
Author(s):  
Leonie Welberg
Keyword(s):  
Neurodegenerative Disease ◽  
Adult Neurogenesis

scholarly journals Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression

2021 ◽  
Vol 124 ◽  
pp. 105097
Author(s):  
Hoda Eliwa ◽  
Bruno Brizard ◽  
Anne-Marie Le Guisquet ◽  
René Hen ◽  
Catherine Belzung ◽  
...  
Keyword(s):  
Mouse Model ◽  
Chronic Stress ◽  
Hpa Axis ◽  
Adult Neurogenesis ◽  
Hpa Axis Dysregulation

scholarly journals Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer’s Disease

2020 ◽  
Vol 58 (1) ◽  
pp. 204-216
Author(s):  
Martina Stazi ◽  
Oliver Wirths
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Recognition Task ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Behavioral Deficits ◽  
Neuron Loss ◽  
Beneficial Effects ◽  
Memantine Treatment

AbstractMemantine, a non-competitive NMDA receptor antagonist possessing neuroprotective properties, belongs to the small group of drugs which have been approved for the treatment of Alzheimer’s disease (AD). While several preclinical studies employing different transgenic AD mouse models have described beneficial effects with regard to rescued behavioral deficits or reduced amyloid plaque pathology, it is largely unknown whether memantine might have beneficial effects on neurodegeneration. In the current study, we assessed whether memantine treatment has an impact on hippocampal neuron loss and associated behavioral deficits in the Tg4-42 mouse model of AD. We demonstrate that a chronic oral memantine treatment for 4 months diminishes hippocampal CA1 neuron loss and rescues learning and memory performance in different behavioral paradigms, such as Morris water maze or a novel object recognition task. Cognitive benefits of chronic memantine treatment were accompanied by an amelioration of impaired adult hippocampal neurogenesis. Taken together, our results demonstrate that memantine successfully counteracts pathological alterations in a preclinical mouse model of AD.

scholarly journals Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161341 ◽  
Author(s):  
Holly J. Garringer ◽  
Jose M. Irimia ◽  
Wei Li ◽  
Charles B. Goodwin ◽  
Briana Richine ◽  
...  
Keyword(s):  
Mouse Model ◽  
Iron Overload ◽  
Neurodegenerative Disease ◽  
Chelation Therapy

scholarly journals Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

2004 ◽  
Vol 164 (4) ◽  
pp. 1495-1502 ◽  
Author(s):  
Christoph Schmitz ◽  
Bart P.F. Rutten ◽  
Andrea Pielen ◽  
Stephanie Schäfer ◽  
Oliver Wirths ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Hippocampal Neuron ◽  
Amyloid Plaque ◽  
Transgenic Mouse Model ◽  
Neuron Loss ◽  
Model Of Alzheimer’S Disease ◽  
Plaque Load

Intracellular Aβ triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease

2010 ◽  
Vol 31 (7) ◽  
pp. 1153-1163 ◽  
Author(s):  
Ditte Z. Christensen ◽  
Thomas A. Bayer ◽  
Oliver Wirths
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cholinergic System ◽  
Neuron Loss ◽  
Model Of Alzheimer’S Disease
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