scholarly journals Mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on GABA release in the dorsal horn of the spinal cord

2019 ◽  
Vol 26 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Eva Koetsier ◽  
Glenn Franken ◽  
Jacques Debets ◽  
Lonne Heijmans ◽  
Sander M.J. Kuijk ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Pain Relief ◽  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Diabetic Polyneuropathy ◽  
Gaba Release

The N-methyl-D-aspartate (NMDA) receptor in skin, dorsal root ganglion and spinal cord: an ideal target gene for RNA interference therapy for pain relief

2017 ◽  
Vol 07 (03) ◽  
Author(s):  
Chia Chih Alex Tseng ◽  
Yuan Yi Chia ◽  
Chien Cheng Liu ◽  
Kuan Ming Feng ◽  
Ping Heng Tan
Keyword(s):  
Spinal Cord ◽  
Rna Interference ◽  
Nmda Receptor ◽  
Pain Relief ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Target Gene

Selective cephalic upregulation of p-ERK, CamKII and p-CREB in response to glyceryl trinitrate infusion

Cephalalgia ◽  
2017 ◽  
Vol 38 (6) ◽  
pp. 1057-1070 ◽  
Author(s):  
Roshni Ramachandran ◽  
Sara Hougaard Pedersen ◽  
Dipak Vasantrao Amrutkar ◽  
Steffen Petersen ◽  
Julie Mie Jacobsen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Trigeminal Ganglion ◽  
Dura Mater ◽  
Dorsal Root ◽  
Spinal Cord Dorsal Horn ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Extracellular Signal

Background A common characteristic of migraine-inducing substances is that they cause headache and no pain in other areas of the body. Few studies have compared pain mechanisms in the trigeminal and spinal systems and, so far, no major differences have been noted. We compared signalling molecules in the trigeminal and spinothalamic system after infusion of the migraine-provoking substance glyceryltrinitrate. Method A catheter was placed in the femoral vein of rats and one week later glyceryltrinitrate 4 µg/kg/min was infused for 20 min. Protein expression in the dura mater, trigeminal ganglion, nucleus caudalis, dorsal root ganglion and the dorsal horn of the thoracic spinal cord was analysed at different time points using western blotting and immunohistochemistry. Results Glyceryltrinitrate caused a threefold increase in expression of phosphorylated extracellular signal-regulated kinases at 30 min in the dura mater and nucleus caudalis ( P < 0.05) and at 2 h in the trigeminal ganglion with very few expressions in the dorsal root ganglion. In the nucleus caudalis, expression of phosphorylated extracellular signal-regulated kinases and Cam KII increased 2.6-fold and 3.2-fold, respectively, at 2 h after glycerytrinitrate infusion ( P < 0.01). p-CREB/ATF-1 upregulation was observed only at 30 min ( P < 0.05) in the nucleus caudalis. None of these markers showed increased expression in the regions of thoracic spinal cord dorsal horn. Conclusion The dura, trigeminal ganglion and nucleus caudalis are activated shortly after glycerytrinitrate infusion with long-lasting expression of phosphorylated extracellular signal-regulated kinases observed in the nucleus caudalis. These activations were not observed at the spinal level.

Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development

2007 ◽  
Vol 58 (4) ◽  
pp. 402-405
Author(s):  
Taro Kato ◽  
Ritsuko Ohtani-Kaneko ◽  
Takashi Shiga
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Erk Activation

Expression and distribution of mTOR, p70S6K, and 4E-BP1 in rat dorsal root ganglion and spinal cord dorsal horn

2010 ◽  
Vol 11 (4) ◽  
pp. S33
Author(s):  
Y. Tao ◽  
J. Xu ◽  
X. Zhao ◽  
M. Yaster ◽  
S. Raja
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Cord Dorsal Horn ◽  
Spinal Cord Dorsal

358 UP-REGULATION OF MICRORNA-16 IN THE DORSAL ROOT GANGLION AND SPINAL CORD DORSAL HORN FOLLOWING PERIPHERAL NERVE INJURY

2007 ◽  
Vol 11 (S1) ◽  
pp. S158-S159
Author(s):  
R. Kusuda ◽  
S. Zanon ◽  
T. Amaral E. Souza ◽  
F. Cadetti ◽  
N. Zanon-Baptista ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglion ◽  
Peripheral Nerve ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Spinal Cord Dorsal Horn ◽  
Spinal Cord Dorsal
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