Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease

2018 ◽  
Vol 43 (5) ◽  
pp. 1273-1282 ◽  
Author(s):  
J.R. Lechien ◽  
C. Finck ◽  
M. Khalife ◽  
K. Huet ◽  
V. Delvaux ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Voice Quality ◽  
Empirical Treatment ◽  
Laryngopharyngeal Reflux Disease

Clinical and Acoustical Voice Quality Evolutions Throughout Empirical Treatment for Laryngopharyngeal Reflux Disease According to Gender: A Preliminary Study

2019 ◽  
Vol 72 (4) ◽  
pp. 257-266 ◽  
Author(s):  
Jérôme R. Lechien ◽  
Kathy Huet ◽  
Camille Finck ◽  
Mohamad Khalife ◽  
Anne-Francoise Fourneau ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Voice Quality ◽  
Empirical Treatment ◽  
Laryngopharyngeal Reflux Disease ◽  
Preliminary Study

scholarly journals Voice Quality Measurement as an Indicator of Efficiency of Treatment in Laryngopharyngeal Reflux Disease

2021 ◽  
Vol 29 (2) ◽  
pp. 169-175
Author(s):  
Fousiya Machancheri ◽  
Mubeena K ◽  
Hemaraja Nayaka
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Voice Quality ◽  
Post Treatment ◽  
P Value ◽  
Maximum Phonation Time ◽  
Perceptual Evaluation ◽  
Number Of Patients ◽  
Hygiene Measures ◽  
Laryngopharyngeal Reflux Disease

Introduction Laryngopharyngeal reflux disease can alter the structural and functional integrity of the vocal fold. Objectives of the study was to determine the effect of Laryngopharyngeal Reflux Disease (LPRD) on selected Acoustic, Aerodynamic and perceptual parameters of voice and to establish its effectiveness in therapeutic outcome. Materials and Methods The number of patients enrolled for this prospective observational study was 65, all with Reflux symptom index (RSI) more than 13. Quality of life was evaluated using voice handicap index (VHI). Perceptual evaluation of voice done by Grade Roughness Breathiness Asthenia Strain score (GRBAS) followed by acoustic and aerodynamic analysis. Patients were started on a once daily proton pump inhibitor therapy for 3 months along with vocal hygiene measures and RSI, VHI and voice analysis repeated after the treatment. Results There was significant improvement in the RSI score after treatment. Percent jitter and shimmer showed significant improvement in males post treatment (p value:<0.05). Harmonic to noise ratio improved 3 months post treatment in both sexes. Improvement noted in Maximum phonation time and GRBAS score except asthenia and strain post treatment. Conclusion Measurement of voice quality can be used as an effective tool to monitor the efficiency of treatment of LPRD.

Voice Quality as Therapeutic Outcome in Laryngopharyngeal Reflux Disease: A Prospective Cohort Study

2020 ◽  
Vol 34 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Jérôme R. Lechien ◽  
Camille Finck ◽  
Kathy Huet ◽  
Anne-Françoise Fourneau ◽  
Mohamad Khalife ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Reflux Disease ◽  
Prospective Cohort ◽  
Laryngopharyngeal Reflux ◽  
Voice Quality ◽  
Therapeutic Outcome ◽  
Laryngopharyngeal Reflux Disease

Optimal Regimen and Period for the Treatment of Patients with Laryngopharyngeal Reflux Disease

2014 ◽  
Vol 57 (10) ◽  
pp. 698 ◽  
Author(s):  
Yun Jae Lee ◽  
Min Kyu Kwak ◽  
Ji Hun Eom ◽  
Yong Bae Ji ◽  
Chang Myeon Song ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease ◽  
Optimal Regimen

Influence of Helicobacter pylori Infection on Laryngopharyngeal Reflux Disease

2006 ◽  
Vol 57 (3) ◽  
pp. 268-272
Author(s):  
Ray Motohashi ◽  
Yusuke Watanabe ◽  
Ryoji Tokashiki ◽  
Kazuhiro Nakamura ◽  
Mamoru Suzuki
Keyword(s):  
Helicobacter Pylori ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Helicobacter Pylori Infection ◽  
Laryngopharyngeal Reflux Disease

Modified Reflux Scintigraphy Detects Pulmonary Microaspiration in Severe Gastro-Esophageal and Laryngopharyngeal Reflux Disease

Lung ◽  
2021 ◽  
Vol 199 (2) ◽  
pp. 139-145
Author(s):  
Jin-soo Park ◽  
Leticia Burton ◽  
Hans Van der Wall ◽  
Gregory Leighton Falk
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease

A Randomized Clinical Trial of Proton Pump Inhibitors Combined with Traditional Chinese Medicine in the Treatment of Laryngopharyngeal Reflux Disease

2021 ◽  
Author(s):  
Feng Pei ◽  
Wei Jia Hu ◽  
Yi Nan Mao ◽  
Yu Liang Zhao
Keyword(s):  
Proton Pump ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Short Form ◽  
Therapeutic Effects ◽  
Reflux Symptom Index ◽  
Symptom Index ◽  
Laryngopharyngeal Reflux Disease ◽  
Group A ◽  
Group B

Background:To explore whether combined with TCM based on classical proton pumpinhibitors PPIs therapy can achieve better efficacy for patients withlaryngopharyngeal reflux disease. Methods: There were 150 laryngopharyngeal refluxpatients enrolled and divided into three groups randomly, with 50 cases in each group.Patients in group A were treated with the proton pump inhibitor (PPI) lansoprazole.Patients in group B were treated with lansoprazole combined with Banxia Houpudecoction, and patients in group C were treated with acupuncture treatments and acombination of Chinese and Western medicine. The reflux symptom index (RSI), refluxfinding score (RFS), and quality of life (36 item short form health survey questionnaire)were assessed before and 4 and 8 weeks after treatment. Results: The RSI and RFSscores of the three groups were significantly reduced after treatment (P < 0.001). Ingroup B and C, they were lower than in group A at 8 weeks (P < 0.01). The SF 36 scoreof 3 groups increased after treatment. At both 4 and 8 weeks (P < 0.001), and patientsin groups B and C scored higher than patients in group A (P < 0.001). The total effectiverate of group B and group C was higher than that of group A (P < 0.05). Conclusion:All three treatments have therapeutic effects on the disease, but the efficacy of a PPIalone is not as good as the combined treatments’ efficacies. Moreover, PPI combinedwith Banxia Houpu decoction and/or acupuncture treatment substantially affects lifeimprovement.

Usefulness of Matrix Metalloproteinase-7 in Saliva as a Diagnostic Biomarker for Laryngopharyngeal Reflux Disease.

2021 ◽  
Author(s):  
Nu-Ri Im ◽  
Byoungjae Kim ◽  
Kwang-Yoon Jung ◽  
Seung-Kuk Baek
Keyword(s):  
Matrix Metalloproteinase ◽  
Sensitivity And Specificity ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Diagnostic Methods ◽  
Reflux Symptom Index ◽  
Enzyme Activity Assay ◽  
Symptom Index ◽  
Laryngopharyngeal Reflux Disease ◽  
Matrix Metalloproteinase 7

Abstract Introduction Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Objectives Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. Method We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. Results There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. Conclusion An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.

scholarly journals Laryngopharyngeal Reflux Disease - LPRD

2017 ◽  
Vol 71 (3) ◽  
pp. 215 ◽  
Author(s):  
Nizama Salihefendic ◽  
Muharem Zildzic ◽  
Emir Cabric
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease
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