Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist

Clinical and Translational Science ◽

10.1111/cts.12711 ◽

2019 ◽

Vol 13 (2) ◽

pp. 309-317

Author(s):

Yan Xu ◽

Xin Miao ◽

Paulien Ravenstijn ◽

Anja Hijzen ◽

Mark E. Schmidt ◽

...

Keyword(s):

Positron Emission Tomography ◽

P2x7 Receptor ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Translational Model ◽

Dose Selection ◽

Tomography Imaging ◽

Positron Emission ◽

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A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor

Respiratory Research ◽

10.1186/s12931-020-01339-7 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Toby M. Maher ◽

Juliet K. Simpson ◽

Joanna C. Porter ◽

Frederick J. Wilson ◽

Robert Chan ◽

...

Keyword(s):

Positron Emission Tomography ◽

Single Dose ◽

Idiopathic Pulmonary Fibrosis ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Target Engagement ◽

Tomography Imaging ◽

Positron Emission ◽

Integrin Inhibitor

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Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study

Drug Metabolism and Disposition ◽

10.1124/dmd.114.058685 ◽

2015 ◽

Vol 43 (11) ◽

pp. 1795-1804 ◽

Author(s):

Li Liu ◽

Ann C. Collier ◽

Jeanne M. Link ◽

Karen B. Domino ◽

David A. Mankoff ◽

...

Keyword(s):

Positron Emission Tomography ◽

Blood Brain Barrier ◽

Human Blood ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Brain Barrier ◽

Tomography Imaging ◽

P Glycoprotein ◽

Positron Emission

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A behavioral and micro positron emission tomography imaging study in a rat model of hypothyroidism

Behavioural Brain Research ◽

10.1016/j.bbr.2014.06.019 ◽

2014 ◽

Vol 271 ◽

pp. 228-233 ◽

Author(s):

Jing Yu ◽

Yi-Yuang Tang ◽

Hong-Bo Feng ◽

Xiao-Xin Cheng

Keyword(s):

Positron Emission Tomography ◽

Rat Model ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Tomography Imaging ◽

Positron Emission

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Elevated Basal Ganglia Glucose Metabolism in Cyclosporine Neurotoxicity: A Positron Emission Tomography Imaging Study

Journal of Neuroimaging ◽

10.1111/j.1552-6569.2002.tb00102.x ◽

2002 ◽

Vol 12 (1) ◽

pp. 92-93 ◽

Author(s):

Michael Andrew Meyer

Keyword(s):

Positron Emission Tomography ◽

Basal Ganglia ◽

Glucose Metabolism ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Tomography Imaging ◽

Positron Emission

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Similar striatal D2/D3 dopamine receptor availability in adults with T ourette syndrome compared with healthy controls: A [ 11 C]‐(+)‐PHNO and [ 11 C]raclopride positron emission tomography imaging study

Human Brain Mapping ◽

10.1002/hbm.22793 ◽

2015 ◽

Vol 36 (7) ◽

pp. 2592-2601 ◽

Author(s):

Elia Abi‐Jaoude ◽

Barbara Segura ◽

Ignacio Obeso ◽

Sang Soo Cho ◽

Sylvain Houle ◽

...

Keyword(s):

Positron Emission Tomography ◽

Dopamine Receptor ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Healthy Controls ◽

Tomography Imaging ◽

Positron Emission

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Cocaine Abuse in Humans Is Not Associated with Increased Microglial Activation: An 18-kDa Translocator Protein Positron Emission Tomography Imaging Study with [11C]PBR28

Journal of Neuroscience ◽

10.1523/jneurosci.0928-14.2014 ◽

2014 ◽

Vol 34 (30) ◽

pp. 9945-9950 ◽

Author(s):

R. Narendran ◽

B. J. Lopresti ◽

N. S. Mason ◽

L. Deuitch ◽

J. Paris ◽

...

Keyword(s):

Positron Emission Tomography ◽

Cocaine Abuse ◽

Microglial Activation ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Translocator Protein ◽

Emission Tomography ◽

Tomography Imaging ◽

Positron Emission

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Serotonin Transporter Availability in Patients with Schizophrenia: A Positron Emission Tomography Imaging Study with [11C]DASB

Biological Psychiatry ◽

10.1016/j.biopsych.2005.02.028 ◽

2005 ◽

Vol 57 (12) ◽

pp. 1510-1516 ◽

Author(s):

W. Gordon Frankle ◽

Rajesh Narendran ◽

Yiyun Huang ◽

Dah-Ren Hwang ◽

Ilise Lombardo ◽

...

Keyword(s):

Positron Emission Tomography ◽

Serotonin Transporter ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Tomography Imaging ◽

Positron Emission

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Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression

Neuroscience ◽

10.1016/j.neuroscience.2010.04.057 ◽

2010 ◽

Vol 169 (1) ◽

pp. 171-181 ◽

Author(s):

H. Hu ◽

L. Su ◽

Y.Q. Xu ◽

H. Zhang ◽

L.W. Wang

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Chronic Mild Stress ◽

Emission Tomography ◽

Mild Stress ◽

Stress Model ◽

Tomography Imaging ◽

Positron Emission

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Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice

Molecular Pharmacology ◽

10.1124/mol.117.110007 ◽

2017 ◽

Vol 93 (2) ◽

pp. 79-89 ◽

Author(s):

Melinda Wuest ◽

Ingrit Hamann ◽

Vincent Bouvet ◽

Darryl Glubrecht ◽

Alison Marshall ◽

...

Keyword(s):

Breast Cancer ◽

Positron Emission Tomography ◽

Molecular Imaging ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Tomography Imaging ◽

Positron Emission

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Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [11C]NOP-1A

American Journal of Psychiatry ◽

10.1176/appi.ajp.2019.18081007 ◽

2019 ◽

Vol 176 (6) ◽

pp. 468-476 ◽

Author(s):

Rajesh Narendran ◽

Savannah Tollefson ◽

Michael L. Himes ◽

Jennifer Paris ◽

Brian Lopresti ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Imaging Study ◽

Emission Tomography ◽

Tomography Imaging ◽

Cocaine Use ◽

Positron Emission

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