BRAF ‐rearranged spindle cell mesenchymal neoplasm with a predominant lipofibromatosis‐like neural tumor pattern and co‐expression of CD34 , S100 protein, and markers associated with perineurial differentiation: a rare case with potential diagnostic pitfall

2021 ◽  
Author(s):  
Ke Sun ◽  
Guo‐qing Ru ◽  
Ming Zhao
Keyword(s):  
Rare Case ◽  
Spindle Cell ◽  
S100 Protein ◽  
Diagnostic Pitfall ◽  
Mesenchymal Neoplasm ◽  
Neural Tumor

Expression of Melanoma Antigens in Epithelioid Gastrointestinal Stromal Tumors: A Potential Diagnostic Pitfall

2008 ◽  
Vol 132 (8) ◽  
pp. 1302-1306 ◽  
Author(s):  
Mehmet L. Guler ◽  
Jason A. Daniels ◽  
Susan C. Abraham ◽  
Elizabeth A. Montgomery
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Spindle Cell ◽  
S100 Protein ◽  
Tissue Microarrays ◽  
Gastric Lesions ◽  
Diagnostic Dilemma ◽  
Stromal Tumors ◽  
Diagnostic Pitfall ◽  
Melanoma Antigens ◽  
Hmb 45

Abstract Context.—Most gastric gastrointestinal stromal tumors (GISTs) express CD117/c-kit, as do a subset of metastatic melanomas, leading to a diagnostic dilemma in some cases. Objective.—To further differentiate GISTs from melanoma, we investigated expression of melanoma markers in GISTs using a well-characterized set of gastric lesions on tissue microarrays. Design.—Tissue microarrays from paraffin-embedded tissue cores from 38 patients were stained with S100 protein, HMB-45, and Melan-A antibodies. All cases had been previously stained with CD117/c-kit and CD34 antibodies. All were reactive with CD117/c-kit, and 88.2% expressed CD34. Results.—S100 protein was focally expressed in 2 (5.3%) of 38 GISTs; these lesions lacked HMB-45 and Melan-A labeling. No tumor labeled with HMB-45, but 4 (10.6%) of 38 cases labeled with Melan-A antibodies. The Melan-A–reactive cases were all S100 negative and CD34 positive. The S100-reactive cases were spindle cell neoplasms, whereas the Melan-A–reactive cases were epithelioid neoplasms (4/9; 44%). An additional 15 standard sections of separate cases of epithelioid GISTs were then labeled with Melan-A, and 5 (33%) of 15 showed at least focal labeling. Conclusions.—Melan-A staining can be encountered in a subset of epithelioid GISTs, a finding that can suggest a differential diagnosis of melanoma. In this series, the Melan-A–reactive cases lacked S100 protein and expressed CD34, both of which would be unlikely in melanoma. As such, a panel approach is best in differentiating epithelioid GISTs from melanoma.

SPINDLE CELL LIPOMA MASQUERADING AS MIXED PYOLARYNGOCELE : A RARE CASE REPORT

2020 ◽  
Vol VOLUME 8 (ISSUE 1) ◽  
pp. 47-51
Author(s):  
Vineet Narula
Keyword(s):  
Rare Case ◽  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Computed Tomographic ◽  
Contrast Enhanced ◽  
Rare Case Report ◽  
Shoulder Region ◽  
Cervical Approach ◽  
Posterior Neck ◽  
Keywords Lipoma

ABSTRACT Spindle Cell Lipoma (SCL) is an uncommon benign tumor of adipose tissue that is usually super􀃶cially located in the posterior neck, back and shoulder region. We report a rare case of SCL in a 39 years old male presenting as neck swelling with c/o stridor and dysphagia. The contrast enhanced computed tomographic scan of neck showed an external and internal part of the swelling traversing through the thyrohyoid membrane suggestive of Mixed Pyolaryngocele. The tumor was excised by a trans-cervical approach but the post operative histopathology was found to be spindle cell Lipoma. We report this case due to its atypical presentation and location. Keywords: Lipoma, Spindle cell, Pyolaryngocele

scholarly journals Aggressive Monophasic Sarcomatoid Carcinoma of Small Intestine - A Rare Case Report With Review of Literature

2012 ◽  
Vol 02 (01) ◽  
pp. 45-47
Author(s):  
Shetty K. Padma ◽  
Harish S. Permi ◽  
C.N. Patil ◽  
Michelle Mathias
Keyword(s):  
Small Intestine ◽  
Rare Case ◽  
Spindle Cell ◽  
Correct Diagnosis ◽  
Sarcomatoid Carcinoma ◽  
Intestinal Wall ◽  
Cell Tumor ◽  
Review Of Literature ◽  
Spindle Cells ◽  
Rare Case Report

AbstractSarcomatoid carcinoma occurring in the small intestine is very rare. They can be monophasic or biphasic. We report a rare case of monophasic Sarcomatoid carcinoma of the small intestine in a 60 year old male patient. The tumor was an ulceronodular mass involving the ileum circumferentially. The tumor infiltrated the full thickness of the intestinal wall and the serosa of an adjacent loop of ileum. Microscopically, the tumor was composed of sheets of malignant spindle cells. The carcinomatous nature of the tumor was evident only after Immunohistochemistry. The diagnosis of sarcomatoid carcinoma should be considered in the differential diagnosis of malignant spindle cell tumor of small intestine and immunohistochemical stains are required for the correct diagnosis.

scholarly journals Spindle cell carcinoma of the parotid- A rare case entity with review of literature

2020 ◽  
Vol 5 (4) ◽  
pp. 323-326
Author(s):  
Kafil Akhtar ◽  
◽  
Sumbul Warsi ◽  
Fauzia Talat ◽  
Mohd Talha ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Rare Case ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Review Of Literature

scholarly journals A Rare Case of Spindle Cell Lipoma of Nose

2012 ◽  
Vol 4 (2) ◽  
pp. 110 ◽  
Author(s):  
Deepalakshmi Tanthry ◽  
PP Devan ◽  
KavithaAshok Kumar ◽  
Rukma Bhandary
Keyword(s):  
Rare Case ◽  
Spindle Cell ◽  
Spindle Cell Lipoma

scholarly journals Paratesticular Embryonal Rhabdomyosarcoma with Lung Metastasis – A Rare Case Report

2020 ◽  
Vol 7 (11) ◽  
pp. C164-168
Author(s):  
Anusha Ganapathi ◽  
Thanka J ◽  
Lawrence D'Cruze ◽  
Barathi G ◽  
Natarajan K ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Spermatic Cord ◽  
Rare Case ◽  
Spindle Cell ◽  
Malignant Tumors ◽  
Embryonal Rhabdomyosarcoma ◽  
Cell Component ◽  
Testicular Tumors ◽  
Spindle Cell Component ◽  
Rare Case Report

Paratesticular rhabdomyosarcomas (RMS) are very rare malignant tumors arising from the mesenchymal tissues of tunica, epididymis or spermatic cord. They present as painless hard masses in inguinoscrotal region, and large tumors can be mistaken for testicular tumors. They can spread to retroperitoneal lymph nodes or hematogenously metastasize to lung, bones and bone marrow. Here, we report a case of Embryonal RMS with spindle cell component presenting with painless scrotal mass and lung metastasis at initial diagnosis.

Epithelioid Leiomyosarcoma of the External Deep Soft Tissue

2002 ◽  
Vol 126 (4) ◽  
pp. 468-470 ◽  
Author(s):  
Tetsuji Yamamoto ◽  
Rieko Minami ◽  
Chiho Ohbayashi ◽  
Mayumi Inaba
Keyword(s):  
Soft Tissue ◽  
Tumor Cells ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Immunohistochemical Analysis ◽  
Deep Soft Tissue ◽  
Cell Component ◽  
Spindle Cell Component

Abstract Epithelioid leiomyosarcoma in the external deep soft tissue is extremely rare. Most epithelioid leiomyosarcomas occur in the uterus. We present a case of epithelioid leiomyosarcoma occurring in the muscle of the thigh of a 78-year-old man. Histologically, the tumor predominantly consisted of round or polygonal cells arranged in sheets with a focal spindle cell component. Immunohistochemical analysis revealed that the tumor cells expressed vimentin, α-smooth muscle actin, and α-sarcomeric actin. The tumor was negative for desmin, S100 protein, glial fibrillary acidic protein, pan-keratin, epithelial membrane antigen, CAM 5.2, HMB-45, leukocyte common antigen, factor VIII–associated antigen, and CD34. Electron microscopically, some tumor cells contained abundant actin-type filaments in their cytoplasm.

Hepatic Angiomyolipoma

2008 ◽  
Vol 132 (10) ◽  
pp. 1679-1682 ◽  
Author(s):  
Amber A. Petrolla ◽  
Wei Xin
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
S100 Protein ◽  
Muscle Cells ◽  
Diagnostic Study ◽  
Hepatic Angiomyolipoma ◽  
Mesenchymal Neoplasm ◽  
Frequent Site ◽  
Males And Females ◽  
Benign Liver

Abstract Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females. Angiomyolipoma occurs most commonly in the kidneys. The liver represents the second most frequent site of involvement. Hepatic angiomyolipomas are composed of varying amounts of smooth muscle cells, adipose tissue, and vessels. The smooth muscle cell component is the most specific to the diagnosis. The smooth muscle cells can have varying morphologies and are positive for homatropine methylbromide–45 but are negative for hepatocyte paraffin 1 and S100 protein. The definitive diagnostic study remains the histologic examination of the surgically resected lesion coupled with immunohistochemical stains. The differential diagnosis includes hepatocellular carcinoma, hepatic adenoma, leiomyoma, hepatoblastoma, melanoma, and gastrointestinal stromal tumor. The immunohistochemical staining pattern differentiates this lesion from other malignant and benign liver lesions. If the diagnosis of hepatic angiomyolipoma has been made, it can be followed conservatively or surgically resected.

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