CDX2 and SATB2 positivity in pilomatrix carcinoma: avoiding an erroneous diagnosis of cutaneous metastasis of gastrointestinal origin

Prostate cancer is the most common cancer affecting men in the United States and the second greatest cause of cancer-related death. Metastases usually occur to bone followed by distant lymph nodes and then viscera. Cutaneous metastases are extremely rare. Their presence indicates advanced disease and a poor prognosis. As they are highly variable in appearance and may mimic a more benign process, biopsy is essential for identification. Serine proteases, particularly human tissue kallikreins, may play an important role in promoting metastasis and facilitate infiltration of the skin. Individual cancer genetics may predispose to more aggressive cancer and thus earlier and more distant metastases. In this article, we report our case of a 67-year-old man with a 4-year history of castrate-resistant prostate cancer with cutaneous metastases confirmed by histology. Despite multiple lines of systemic therapy, the patient suffered progressive disease with worsening performance status and was enrolled in hospice.

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Cutaneous metastasis from esophageal basaloid squamous cell carcinoma: A case report

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2021.02.007 ◽

2021 ◽

Vol 80 ◽

pp. 105621

Author(s):

Fumitaka Endo ◽

Yuji Akiyama ◽

Masazumi Onishi ◽

Noriyuki Uesugi ◽

Tamotsu Sugai ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cutaneous Metastasis ◽

Basaloid Squamous Cell Carcinoma ◽

Basaloid Squamous

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Cutaneous metastasis of unknown primary presenting as massive and invasive abdominal lesion: an elective approach

Anais Brasileiros de Dermatologia ◽

10.1590/abd1806-4841.20153793 ◽

2015 ◽

Vol 90 (6) ◽

pp. 879-882 ◽

Cited By ~ 1

Author(s):

Paolo Lido ◽

Giovanni Paolino ◽

Andrea Feliziani ◽

Letizia Santurro ◽

Mauro Montuori ◽

...

Keyword(s):

Cutaneous Metastasis ◽

Unknown Primary ◽

Abdominal Lesion

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Pilomatrix Carcinoma in a Patient With Type 1 Myotonic Dystrophy: A Case Report

Plastic Surgery Case Studies ◽

10.1177/2513826x19898833 ◽

2020 ◽

Vol 6 ◽

pp. 2513826X1989883

Author(s):

Sarah L. Zhu ◽

David Choi ◽

Jenny Santos ◽

Bernard S. Jackson ◽

Matthew McRae

Keyword(s):

Case Report ◽

Myotonic Dystrophy ◽

Latissimus Dorsi ◽

Myocutaneous Flap ◽

Myotonic Dystrophy Type 1 ◽

Myotonic Dystrophy Type ◽

Genetic Condition ◽

Latissimus Dorsi Myocutaneous Flap ◽

Pilomatrix Carcinoma

This is the first report of pilomatrix carcinoma in a man with C282Y myotonic dystrophy type 1. This pilomatrix carcinoma had originally presented as a rapidly growing recurrence of a histopathologically confirmed pilomatrixoma, removed a year prior. On examination, the fungating mass had measured 10 × 23 cm. A wide local resection with removal of suspicious lymph nodes was preformed, and the resulting defect was reconstructed with a latissimus dorsi myocutaneous flap and skin graft. Histologic investigation of the excised mass confirmed the diagnosis of pilomatrix carcinoma. This is the first reported case of pilomatrix carcinoma in a patient with a genetic condition that often presents with scalp pilomatrixomas. Potential implications of myotonic dystrophy on developing pilomatrix carcinoma are discussed.

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