Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery‐induced weight loss

2018 ◽  
Vol 20 (5) ◽  
pp. 1280-1288 ◽  
Author(s):  
Prince Dadson ◽  
Jarna C. Hannukainen ◽  
Mueez U Din ◽  
Minna Lahesmaa ◽  
Kari K. Kalliokoski ◽  
...  
2020 ◽  
Author(s):  
G Lenihan-Geels ◽  
F Garcia-Carrizo ◽  
C Li ◽  
M Oster ◽  
A Prokesch ◽  
...  

2017 ◽  
Vol 313 (6) ◽  
pp. E731-E736 ◽  
Author(s):  
Wenjuan Wang ◽  
Xiangzhi Meng ◽  
Chun Yang ◽  
Dongliang Fang ◽  
Xuemeng Wang ◽  
...  

Loss of body weight and fat mass is one of the nonmotor symptoms of Parkinson’s disease (PD). Weight loss is due primarily to reduced energy intake and increased energy expenditure. Whereas inadequate energy intake in PD patients is caused mainly by appetite loss and impaired gastrointestinal absorption, the underlying mechanisms for increased energy expenditure remain largely unknown. Brown adipose tissue (BAT), a key thermogenic tissue in humans and other mammals, plays an important role in thermoregulation and energy metabolism; however, it has not been tested whether BAT is involved in the negative energy balance in PD. Here, using the 6-hydroxydopamine (6-OHDA) rat model of PD, we found that the activity of sympathetic nerve (SN), the expression of Ucp1 in BAT, and thermogenesis were increased in PD rats. BAT sympathetic denervation blocked sympathetic activity and decreased UCP1 expression in BAT and attenuated the loss of body weight in PD rats. Interestingly, sympathetic denervation of BAT was associated with decreased sympathetic tone and lipolysis in retroperitoneal and epididymal white adipose tissue. Our data suggeste that BAT-mediated thermogenesis may contribute to weight loss in PD.


2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Priscila Cassolla ◽  
Maria Antonieta R. Garófalo ◽  
Juliana B. Guimarães ◽  
Frederico S. M. Machado ◽  
Coimbra C. Cândido ◽  
...  

2019 ◽  
Vol 24 ◽  
pp. 1-17 ◽  
Author(s):  
Sabrina Gohlke ◽  
Vyacheslav Zagoriy ◽  
Alvaro Cuadros Inostroza ◽  
Michaël Méret ◽  
Carola Mancini ◽  
...  

Methods ◽  
2017 ◽  
Vol 130 ◽  
pp. 105-113 ◽  
Author(s):  
Andreas Paulus ◽  
Wouter van Marken Lichtenbelt ◽  
Felix M. Mottaghy ◽  
Matthias Bauwens

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Xiaoliang Shao ◽  
Wei Yang ◽  
Xiaonan Shao ◽  
Chun Qiu ◽  
Xiaosong Wang ◽  
...  

2012 ◽  
Vol 97 (7) ◽  
pp. E1229-E1233 ◽  
Author(s):  
G. H. E. J. Vijgen ◽  
N. D. Bouvy ◽  
G. J. J. Teule ◽  
B. Brans ◽  
J. Hoeks ◽  
...  

2008 ◽  
Vol 7 (1) ◽  
pp. 26 ◽  
Author(s):  
Denis Martinez ◽  
Luiz FT Vasconcellos ◽  
Patricia G de Oliveira ◽  
Signorá P Konrad

2015 ◽  
Vol 4 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Colin N. Young ◽  
Donald A. Morgan ◽  
Scott D. Butler ◽  
Kamal Rahmouni ◽  
Susan B. Gurley ◽  
...  

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