Effects of canagliflozin on major adverse cardiovascular events by baseline estimated glomerular filtration rate: Pooled Hispanic subgroup analyses from the CANVAS Program and CREDENCE trial

2021 ◽  
Author(s):  
Matthew R. Weir ◽  
Jagadish Gogate ◽  
C.V. Damaraju ◽  
Ricardo Correa‐Rotter ◽  
Kenneth W. Mahaffey
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Major Adverse Cardiovascular Events ◽  
Subgroup Analyses ◽  
Hispanic Subgroup

Abstract 6277: Predictive Value of Estimated Glomerular Filtration Rate for Cardiovascular Events: The Treating to New Targets Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
James Shepherd ◽  
Chuan-Chuan Wun ◽  
Daniel J Wilson ◽  
Andrea L Zuckerman
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Lipid Lowering ◽  
Final Visit ◽  
The Relationship ◽  
Dose Dependent

We previously demonstrated a dose-dependent improvement in renal function and reduction in cardiovascular risk in TNT with intensive lipid lowering with atorvastatin (ATV) 80 mg vs 10 mg. This post hoc analysis examines the relationship between the observed improvement in estimated glomerular filtration rate (eGFR) and reduction of major cardiovascular events (MCVE). After 8 weeks open-label therapy with ATV 10 mg, 10,001 patients with CHD were randomized to double-blind therapy with either ATV 10 or 80 mg. Patients were followed for a median of 4.9 years for the occurrence of MCVEs (CHD death, nonfatal MI, and stroke). The relationship between change from baseline eGFR (using the MDRD equation) at the final visit prior to a MCVE and the risk of MCVE was assessed using a Cox proportional hazards model adjusting for baseline eGFR and other baseline characteristics. Of 9656 patients with complete renal data, 156 had a MCVE before follow-up eGFR assessment and were excluded. In the remaining 9500 patients, mean baseline eGFR was 65.3 mL/min/1.73 m 2 and mean change from baseline was 4.3 mL/min/1.73 m 2 . This represented a reduction in the risk of MCVE of 2.7% per mL increase in eGFR (HR 0.973, 95% CI 0.967– 0.980, P <0.0001). This association remained significant in patients with eGFR <60 and those with eGFR ≥60 mL/min/1.73 m 2 at baseline, with no significant interaction between eGFR change and baseline renal status ( P =0.98). A 5 mL/min on-treatment improvement in eGFR was associated with a 12.6% reduction in MCVE, while a 5 mL/min reduction was associated with a 14.4% increase in MCVE. Mean change from baseline eGFR was 3.5 mL/min/1.73 m 2 with ATV 10 mg and 5.2 mL/min/1.73 m 2 with ATV 80 mg, representing significant 9.3% and 12.4% reductions in risk, respectively. Analysis of interaction between treatment and eGFR change for prediction of MCVE demonstrated a stronger association between eGFR change and MCVE in the ATV 80 mg treatment group ( P =0.011). Improvement in eGFR was highly associated with a reduction in MCVE, irrespective of baseline renal function. This relationship was dose dependent. Improvement in eGFR may be a biomarker for the response to atorvastatin, and for the stabilization of atherosclerotic cardiovascular disease.

Changes in estimated glomerular filtration rate in chronic myeloid leukemia patients treated front line with available TKIs and correlation with cardiovascular events

2018 ◽  
Vol 97 (10) ◽  
pp. 1803-1808 ◽  
Author(s):  
Matteo Molica ◽  
Emilia Scalzulli ◽  
Gioia Colafigli ◽  
Danilo Alunni Fegatelli ◽  
Fulvio Massaro ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Chronic Myeloid Leukemia ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Myeloid Leukemia ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Front Line

Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria

Nephrology ◽  
2014 ◽  
Vol 19 (9) ◽  
pp. 574-580 ◽  
Author(s):  
Kei Nagai ◽  
Kunihiro Yamagata ◽  
Reiko Ohkubo ◽  
Chie Saito ◽  
Koichi Asahi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Annual Decline

Estimated glomerular filtration rate, inflammation, and cardiovascular events after an acute coronary syndrome

2008 ◽  
Vol 155 (4) ◽  
pp. 725-731 ◽  
Author(s):  
Lisa M. Mielniczuk ◽  
Marc A. Pfeffer ◽  
Eldrin F. Lewis ◽  
Michael A. Blazing ◽  
James A. de Lemos ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Coronary Syndrome

scholarly journals Patterns of chronic and transient hyperkalaemia and clinically important outcomes in patients with chronic kidney disease

2021 ◽  
Author(s):  
Marco Trevisan ◽  
Catherine M Clase ◽  
Marie Evans ◽  
Tamara Popov ◽  
Jonas F Ludvigsson ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Outpatient Care ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Major Adverse Cardiovascular Events ◽  
Risk Of Death

Abstract Background Whether hyperkalaemia in CKD is chronic or transient, and whether this has different outcome implications, is not known. Methods This was an observational study of adults with CKD G3–5 from Stockholm, Sweden 2006–11. We examined individual trajectories of potassium from all measurements obtained through routine outpatient care. For each month of follow-up, we created a rolling assessment of the proportion of time in which potassium was abnormal during the previous 12 months. We defined patterns of hyperkalaemia as transient (≤50% of time during the previous year with potassium &gt;5.0 mmol/L) and chronic (&gt;50% of time with potassium &gt;5.0 mmol/L), and examined whether previous hyperkalaemia pattern offers additional predictive value beyond that provided by the most recent (current) potassium value. Results We included 36 511 participants (56% women) with CKD G3–5 and median estimated glomerular filtration rate 46 mL/min/1.73 m2. Transient and chronic hyperkalaemia, respectively, were observed in 15% and 4% of patients with CKD G3a, and in 50% and 17% of patients with CKD G5. In fully adjusted models, transient (hazard ratio 1.36, 95% confidence interval 1.29–1.46) or chronic (1.16, 1.04–1.32) hyperkalaemia patterns, but not current hyperkalaemia, were associated with major adverse cardiovascular events (MACE), compared with normokalaemia. Transient hyperkalaemia (1.43, 1.35–1.52) and current potassium values, but not chronic hyperkalaemia, were associated with the risk of death. Conclusions Between 4% and 17% of patients with CKD G3–5 develop chronic hyperkalaemia. In general, hyperkalaemia predicted MACE and death; however, the lack of effect of current potassium on MACE when adjusted for the previous pattern, and the stronger effects on death than on MACE, lead us to question whether hyperkalaemia is causal in these relationships.

Estimated Glomerular Filtration Rate, Cardiovascular Events and Mortality Across Age Groups Among Individuals Older Than 60 Years in Southern Europe

2018 ◽  
Vol 71 (6) ◽  
pp. 450-457
Author(s):  
Betlem Salvador-González ◽  
Neus Gil-Terrón ◽  
M. Jesús Cerain-Herrero ◽  
Isaac Subirana ◽  
Roser Güell-Miró ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Age Groups ◽  
Southern Europe

Combined effect of albuminuria and estimated glomerular filtration rate on cardiovascular events and all-cause mortality in uncomplicated hypertensive patients

2010 ◽  
Vol 28 (4) ◽  
pp. 848-855 ◽  
Author(s):  
Francesca Viazzi ◽  
Giovanna Leoncini ◽  
Novella Conti ◽  
Cinzia Tomolillo ◽  
Giovanna Giachero ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Combined Effect ◽  
Hypertensive Patients ◽  
All Cause Mortality
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