Succesful treatment of erythema nodosum leprosum with apremilast

2021 ◽  
Author(s):  
Carlos Abril‐Pérez ◽  
Rodolfo David Palacios‐Diaz ◽  
Miguel Ángel Navarro‐Mira ◽  
Rafael Botella‐Estrada
1989 ◽  
Vol 51 (3) ◽  
pp. 441-446 ◽  
Author(s):  
Motoaki OZAKI ◽  
Kohozou YONEDA ◽  
Keiji OHTA ◽  
Miyuki OHTA

2021 ◽  
pp. 004947552199849
Author(s):  
Prakriti Shukla ◽  
Kiran Preet Malhotra ◽  
Parul Verma ◽  
Swastika Suvirya ◽  
Abir Saraswat ◽  
...  

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley–Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. We found 17/386 leprosy patients with non-neuropathic ulcers. We describe three causes – spontaneous cutaneous ulceration in lepromatous leprosy (one nodular and one diffuse), lepra reactions (five patients with type 1; nine with type 2, further categorised into ulcerated Sweet syndrome-like who also had pseudoepitheliomatous hyperplasia, pustulo-necrotic and necrotic erythema nodosum leprosum) and Lucio phenomenon (one patient). Our series draws attention towards the different faces of non-neuropathic ulcers in leprosy, including some atypical and novel presentations.


2021 ◽  
pp. 004947552110561
Author(s):  
Hitaishi Mehta ◽  
Tarun Narang ◽  
Sunil Dogra ◽  
Bhushan Kumar

We read with interest the short report by Rani et al. entitled “An uncommon variant of erythema nodosum leprosum responding well to methotrexate: Report of two cases.” The article describes two cases of erythema nodosum leprosum (ENL) with ‘atypical features’ and good response to low dose methotrexate. The authors address a few concerns regarding methotrexate in ENL, emphasizing the rational usage of this agent.


2017 ◽  
Vol 11 (10) ◽  
pp. e0006001 ◽  
Author(s):  
Edessa Negera ◽  
Stephen L. Walker ◽  
Kidist Bobosha ◽  
Rawleigh Howe ◽  
Abraham Aseffa ◽  
...  

2019 ◽  
Vol 53 (2) ◽  
Author(s):  
Mia Katrina R. Gervasio ◽  
Felix Paolo J. Lizarondo ◽  
Belen L. Dofitas

Background. Erythema nodosum leprosum is an immune-mediated complication of leprosy whose underlying mechanism has not yet been fully elucidated, making management difficult.Objectives. To determine the serum cytokine profile of ENL compared to non-reactional leprosy states. Methods. An open literature search was performed using MEDLINE, Cochrane Library, TRIP and HERDIN electronic databases using the keywords ("cytokines" or “inflammatory mediators”) and (“erythema nodosum leprosum” or “ENL”) and (“leprosy” or “lepra”). Studies were selected by two independent review authors. Risk of bias was assessed using the Newcastle-Ottawa Scale and statistical analysis was performed using RevMan 5.3 software. Results. Eight cross-sectional studies with 197 participants were included. Meta-analysis showed that both serum IL-17 and serum IFN-γ were significantly decreased (Z 2.39, p = 0.02 and Z 2.74, p = 0.01, respectively) in ENL compared to non-reactional states. However, for IL-1β, IL-6, IL-10, IL-22, TNF-α and TGF-β, no significant differences were found between the two groups. Conlusion. ENL appears to be an exacerbation of the Th2 cytokine response seen in the lepromatous pole of leprosy. However, despite pooling of data, sample sizes remain small resulting in significant heterogeneity. Future studies involving large sample sizes and investigating a wider range of cytokines are encouraged.


2021 ◽  
Vol 22 (4) ◽  
pp. 352
Author(s):  
Anwita Sinha ◽  
Vidhu Dangwal ◽  
AchintaK R. Mallick ◽  
AnchitRaj Singh ◽  
Asmita Sinha

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