scholarly journals Association between lung ultrasound B‐lines and exercise‐induced pulmonary hypertension in patients with connective tissue disease

2021 ◽  
Author(s):  
Kazuki Kagami ◽  
Tomonari Harada ◽  
Koichi Yamaguchi ◽  
Shunichi Kouno ◽  
Takahiro Ikoma ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Lung Ultrasound ◽  
Exercise Induced ◽  
B Lines

scholarly journals Association between Lung Ultrasound B-lines and Exercise-Induced Pulmonary Hypertension in Patients with Connective Tissue Disease

2021 ◽  
Author(s):  
Kazuki Kagami ◽  
Tomonari Harada ◽  
Koichi Yamaguchi ◽  
Shunichi Kouno ◽  
Takahiro Ikoma ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Pulmonary Artery ◽  
Connective Tissue Disease ◽  
Lung Ultrasound ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
Peak Exercise ◽  
Exercise Induced ◽  
B Lines

Background: Identification of elevation in pulmonary pressures during exercise may provide prognostic and therapeutic implications in patients with connective tissue disease (CTD). Interstitial lung disease (ILD) is common in CTD patients and subtle interstitial abnormalities detected by lung ultrasound could predict exercise-induced pulmonary hypertension (PH). Methods and Results: Echocardiography and lung ultrasound were performed at rest and bicycle exercise in CTD patients (n=41) and control subjects without CTD (n=24). Ultrasound B-lines were quantified by scanning four intercostal spaces in the right hemithorax. We examined the association between total B-lines at rest and the development of exercise-induced PH during ergometry exercise. Compared to controls, the number of total B-lines at rest was higher in CTD patients (0 [0, 0] vs. 2 [0, 9], p<0.0001) and was correlated with radiological severity of ILD assessed by computed tomography (fibrosis score, r=0.70, p<0.0001). Pulmonary artery systolic pressure (PASP) was increased with ergometry exercise in CTD compared to controls (48±14 vs. 35±13 mmHg, p=0.0006). The number of total B-lines at rest was highly correlated with higher PASP (r=0.52, p<0.0001) and poor right ventricular pulmonary artery coupling (tricuspid annular plane systolic excursion/PASP ratio, r=-0.31, p=0.01) during peak exercise. The number of resting B-lines predicted the development of exercise-induced PH with an area under the curve 0.79 (p=0.0003). Conclusions: These data may suggest the value of a simple resting assessment of lung ultrasound as a potential tool for assessing the risk of exercise-induced PH in CTD patients.

Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease

2019 ◽  
Vol 34 (9) ◽  
pp. 1509-1518
Author(s):  
Sunao Miyanaga ◽  
Kayoko Kubota ◽  
Noriko Iwatani ◽  
Kenjuro Higo ◽  
Masaaki Miyata ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Exercise Induced

scholarly journals Significant Clinical Indexes of Exercise-Induced Pulmonary Hypertension in Patients With Connective Tissue Disease

2019 ◽  
Vol 1 (12) ◽  
pp. 610-616
Author(s):  
Satoko Ojima ◽  
Takuro Kubozono ◽  
Keishi Saihara ◽  
Takahiro Miyauchi ◽  
Shin Kawasoe ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Exercise Induced

Classification tree criteria of pulmonary hypertension in mixed connective tissue disease

1997 ◽  
Vol 7 (4) ◽  
pp. 293-303
Author(s):  
Lisa Kotajima ◽  
Shinichi Aotsuka ◽  
Tomoe Nishimaki ◽  
Heihachiro Kashiwagi ◽  
Takeyoshi Kunieda ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Classification Tree

scholarly journals Fatal Pulmonary Hypertension in a Patient with Mixed Connective Tissue Disease: Report of an Autopsy Case.

1992 ◽  
Vol 31 (1) ◽  
pp. 74-77 ◽  
Author(s):  
Makoto SUZUKI ◽  
Mareomi HAMADA ◽  
Michihito SEKIYA ◽  
Yuji SHIGEMATSU ◽  
Soei GO ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Autopsy Case
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