Matrix metalloproteinase-9, 10, and stress hyperglycaemia in acute kidney injury

2018 ◽  
Vol 48 (7) ◽  
pp. e12963 ◽  
Author(s):  
Guray Guvercin ◽  
Volkan Karakus ◽  
Murat Aksit ◽  
Yelda Dere ◽  
Merve Aktar ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Matrix Metalloproteinase ◽  
Kidney Injury ◽  
Matrix Metalloproteinase 9 ◽  
Stress Hyperglycaemia ◽  
Metalloproteinase 9

scholarly journals Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury

2015 ◽  
Vol 237 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Suzana Bojic ◽  
Jelena Kotur-Stevuljevic ◽  
Nevena Kalezic ◽  
Predrag Stevanovic ◽  
Zorana Jelic-Ivanovic ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Matrix Metalloproteinase ◽  
Kidney Injury ◽  
Diagnostic Value ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1 ◽  
Metalloproteinase 9

scholarly journals Urinary Matrix Metalloproteinase-9 and Nephrin in Idiopathic Membranous Nephropathy: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Akankwasa Gilbert ◽  
An Changjuan ◽  
Cheng Guixue ◽  
Liu Jianhua ◽  
Qin Xiaosong
Keyword(s):  
Matrix Metalloproteinase ◽  
Membranous Nephropathy ◽  
Healthy Subjects ◽  
Kidney Injury ◽  
Matrix Metalloproteinase 9 ◽  
Idiopathic Membranous Nephropathy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Glomerular Diseases ◽  
Metalloproteinase 9

Aim. Idiopathic membranous nephropathy (IMN) has a varied clinical course that requires accurate prediction as a prerequisite for treatment administration. Currently, its prognosis relies on proteinuria, a clinical parameter whose onset lags behind kidney injury. Increased urinary excretion of matrix metalloproteinase-9 (MMP-9) and nephrin has been reported in a number of IMN-like glomerular diseases in which they reflected disease severity. However, little or nothing is known of the importance of these biomarkers in IMN, a major cause of adult nephrotic syndrome. To highlight their potential, we measured both biomarkers and assessed their relationships with key parameters of renal function in IMN. Methods. We quantified urinary MMP-9 and nephrin in 107 biopsy-proven IMN patients and 70 healthy subjects by enzyme-linked immunosorbent assay (ELISA). We then compared biomarker levels between patients and healthy subjects and among patients with different clinical features. We also determined the relationship of each biomarker with proteinuria and the estimated glomerular filtration rate (eGFR). Results. Urinary MMP-9 and nephrin were significantly higher in IMN compared to healthy controls. Unlike nephrin, MMP-9 correlated significantly with proteinuria and was significantly higher among patients with nephrotic range proteinuria. Both biomarkers were correlated with eGFR, but only MMP-9 was significantly higher in patients with eGFR less than 90 ml/min/1.73 m2. Conclusion. Our findings suggest that urinary MMP-9 holds a greater potential than urinary nephrin in monitoring the severity of IMN.

scholarly journals Puerarin Attenuated Early Diabetic Kidney Injury through Down-Regulation of Matrix Metalloproteinase 9 in Streptozotocin-Induced Diabetic Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85690 ◽  
Author(s):  
Yifei Zhong ◽  
Xianwen Zhang ◽  
Xianfan Cai ◽  
Ke Wang ◽  
Yiping Chen ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Kidney Injury ◽  
Diabetic Rats ◽  
Matrix Metalloproteinase 9 ◽  
Down Regulation ◽  
Diabetic Kidney ◽  
Metalloproteinase 9

473 Adenosine stimulates matrix metalloproteinase-9 secretion by THP-1-derived macrophages

2007 ◽  
Vol 6 (1) ◽  
pp. 102-102
Author(s):  
E VELOT ◽  
I ERNENS ◽  
B HAAS ◽  
C JEANTY ◽  
D ROUY ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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