Mild chronic graft-versus-host disease may alleviate poor prognosis associated with FLT3 internal tandem duplication for adult acute myeloid leukemia following allogeneic stem cell transplantation with myeloablative conditioning in first complete remissio

2015 ◽  
Vol 96 (3) ◽  
pp. 236-244 ◽  
Author(s):  
Barbara Nasilowska-Adamska ◽  
Anna Czyz ◽  
Miroslaw Markiewicz ◽  
Piotr Rzepecki ◽  
Beata Piatkowska-Jakubas ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Tandem Duplication ◽  
Myeloablative Conditioning ◽  
Internal Tandem Duplication ◽  
Graft Versus Host ◽  
Flt3 Internal Tandem Duplication ◽  
Acute Myeloid

scholarly journals Successful treatment of post-transplant relapsed acute myeloid leukemia with FLT3 internal tandem duplication using the combination of induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine. Report of three cases

2017 ◽  
Vol 15 (3) ◽  
pp. 355-358 ◽  
Author(s):  
Paulo Vidal Campregher ◽  
Vinicius Renan Pinto de Mattos ◽  
Marco Aurélio Salvino ◽  
Fabio Pires de Souza Santos ◽  
Nelson Hamerschlak
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Myeloid Leukemia ◽  
Tandem Duplication ◽  
Donor Lymphocyte Infusion ◽  
Internal Tandem Duplication ◽  
Hematopoietic Stem ◽  
Flt3 Internal Tandem Duplication ◽  
Acute Myeloid

ABSTRACT Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality. The presence of FLT3 internal tandem duplication mutations leads to high rates of relapse and decreased overall survival. Patients with FLT3 internal tandem duplication are normally treated with hematopoietic stem cell transplantation in first complete remission. Nevertheless, the incidence of post-transplant relapse is considerable in this group of patients, and the management of this clinical condition is challenging. The report describes the outcomes of patients with FLT3 internal tandem duplication positive acute myeloid leukemia who relapsed after allogeneic hematopoietic stem cell transplantation and were treated with the combination of re-induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine. Three cases are described and all patients achieved prolonged complete remission with the combined therapy. The combination of induction chemotherapy followed by donor lymphocyte infusion, and the maintenance with azacitidine and sorafenib can be effective approaches in the treatment of post-hematopoietic stem cell transplant and relapsed FLT3 internal tandem duplication positive acute myeloid leukemia patients. This strategy should be further explored in the context of clinical trials.

FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype

2007 ◽  
Vol 42 (3) ◽  
pp. 250 ◽  
Author(s):  
Sang-Ho Kim ◽  
Yeo-Kyeoung Kim ◽  
Il-Kwon Lee ◽  
Deog-Yeon Jo ◽  
Jong-Ho Won ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Tandem Duplication ◽  
Normal Karyotype ◽  
Internal Tandem Duplication ◽  
Flt3 Internal Tandem Duplication ◽  
Acute Myeloid
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