scholarly journals Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip

2013 ◽  
Vol 38 (2) ◽  
pp. 2338-2338
Author(s):  
Tiziana Cotrufo ◽  
Rosa María Andrés ◽  
Oriol Ros ◽  
Francesc Pérez-Brangulí ◽  
Ashraf Muhaisen ◽  
...  
Keyword(s):  
Rhombic Lip

Role of Pax6 in development of the cerebellar system

Development ◽  
1999 ◽  
Vol 126 (16) ◽  
pp. 3585-3596 ◽  
Author(s):  
D. Engelkamp ◽  
P. Rashbass ◽  
A. Seawright ◽  
V. van Heyningen
Keyword(s):  
Cell Proliferation ◽  
Cell Migration ◽  
Granule Cell ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Long Distance ◽  
Cerebellar Granule ◽  
Precerebellar Nuclei ◽  
Rhombic Lip

Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6(Sey)/Pax6(Sey)) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6(Sey)/Pax6(Sey) granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.

The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Katrin Volkmann ◽  
Yi-Yen Chen ◽  
Matthew P. Harris ◽  
Mario F. Wullimann ◽  
Reinhard W. Köster
Keyword(s):  
Long Distance ◽  
Rhombic Lip

scholarly journals Rautenlippe Redux—toward a unified view of the precerebellar rhombic lip

2009 ◽  
Vol 21 (6) ◽  
pp. 741-747 ◽  
Author(s):  
Russell S Ray ◽  
Susan M Dymecki
Keyword(s):  
Unified View ◽  
Rhombic Lip

scholarly journals Development of an in vitro electroporation assay in the mouse to manipulate gene expression in the lower rhombic lip

2010 ◽  
Vol 344 (1) ◽  
pp. 497
Author(s):  
Rebecca L. Landsberg ◽  
Susan M. Dymecki ◽  
Patrick Holland
Keyword(s):  
Gene Expression ◽  
Rhombic Lip

scholarly journals The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs)

Development ◽  
2002 ◽  
Vol 129 (4) ◽  
pp. 983-991 ◽  
Author(s):  
Astrid Vogel-Höpker ◽  
Hermann Rohrer
Keyword(s):  
Transcription Factors ◽  
Locus Coeruleus ◽  
Bone Morphogenetic Proteins ◽  
Chick Embryos ◽  
Dorsal Midline ◽  
Neural Crest Development ◽  
Roof Plate ◽  
Rhombic Lip ◽  
The Brain

The role of BMPs in the development of the major noradrenergic centre of the brain, the locus coeruleus (LC), was investigated. LC generation is reflected by initial expression of the transcription factors Phox2a and Phox2b in dorsal rhombomere1 (r1), followed by expression of dopamine-β-hydroxylase and tyrosine hydroxylase. Bmp5 is expressed in the dorsal neuroepithelium in proximity to Phox2-expressing cells. BMP inhibition in stage 10 chick embryos resulted in the lack of LC neurones or in their generation at the dorsal midline, and loss of roof plate and rhombic lip, but it did not affect neural crest development. These results reveal late essential BMP functions in the specification of dorsal neuronal phenotypes in r1, including LC neurones, and in the development of dorsal midline structures.

scholarly journals Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Alexandre Wojcinski ◽  
Morgane Morabito ◽  
Andrew K. Lawton ◽  
Daniel N. Stephen ◽  
Alexandra L. Joyner
Keyword(s):  
Ventricular Zone ◽  
Genetic Deletion ◽  
Rhombic Lip
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