Orexin A depolarises rat intergeniculate leaflet neurons through non‐selective cation channels

Aim. To conduct a comparative analysis of serum orexin A levels in women of different age periods with and without sleep disorder and vasomotor symptoms. To evaluate the dynamics of orexin A levels under menopausal hormone therapy. Materials and methods. The study included 50 postmenopausal women and 30 women of reproductive age with a regular menstrual cycle. Using block randomization, patients are divided into 3 groups: group 1 (main group), n=25, -STRAW+ 10 (+1b and +1c), patients with sleep disorder and vasomotor symptoms; group 2 (comparison group), n=25, STRAW+ 10 (+1b and +1c), patients with vasomotor symptoms without sleep disorder; group 3 (control group), n=30, STRAW+ 10 (-4), women of reproductive age without sleep disorder. Group 1 patients were given menopausal hormone therapy. A comparative analysis was carried out using the questionnaire for assessing menopausal symptoms severity by the Greene Scale (the Greene Climacteric Scale) and Rating Scale for subjective sleep characteristics. After 12 weeks of treatment, a control examination was performed. Results. In group 1 women, the serum orexin A levels were significantly higher compared to the women without the symptoms. The link between the orexin A levels and menopause syndrome severity was established. A significant decrease in the menopausal symptoms severity after 12 weeks of menopausal hormone therapy was shown. It was accompanied by a 1,3-fold decrease in orexin A levels. Conclusions. The obtained data indicate the possible role of orexin A and the orexin neuropeptide system in the pathogenesis of sleep disorder and vasomotor symptoms in postmenopausal women.

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Faculty Opinions recommendation of Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009135.119309 ◽

2002 ◽

Author(s):

Gary Aston-Jones

Keyword(s):

Area Postrema ◽

Orexin A

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Faculty Opinions recommendation of Orexin A reverses propofol and thiopental induced cytoskeletal rearrangement in rat neurons.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732536254.793541878 ◽

2018 ◽

Author(s):

Roderic Eckenhoff

Keyword(s):

Orexin A ◽

Cytoskeletal Rearrangement

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Cyclopiazonic acid stimulates Ca2+ influx through non-specific cation channels in endothelial cells

European Journal of Pharmacology ◽

10.1016/0014-2999(94)90391-3 ◽

1994 ◽

Vol 251 (2-3) ◽

pp. 119-125 ◽

Cited By ~ 44

Author(s):

He Zhang ◽

Masato Inazu ◽

Bryce Weir ◽

Michael Buchanan ◽

Ed Daniel

Keyword(s):

Endothelial Cells ◽

Cyclopiazonic Acid ◽

Cation Channels

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Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma

Biomolecules ◽

10.3390/biom11071021 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1021

Author(s):

Carla Abrahamian ◽

Christian Grimm

Keyword(s):

Breast Cancer ◽

Gene Expression ◽

Transcription Factor ◽

Convincing Evidence ◽

Signaling Cascades ◽

Cation Channels ◽

Pore Channel ◽

Different Types ◽

Canonical Wnt ◽

The Relationship

Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has been provided attesting key roles of endolysosomal cation channels, specifically TPCs and TRPMLs, in cancer, including breast cancer, glioblastoma, bladder cancer, hepatocellular carcinoma and melanoma. In this review, we provide a gene expression profile of these channels in different types of cancers and decipher their roles, in particular the roles of two-pore channel 2 (TPC2) and TRPML1 in melanocytes and melanoma. We specifically discuss the signaling cascades regulating MITF and the relationship between endolysosomal cation channels, MAPK, canonical Wnt/GSK3 pathways and MITF.

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Orexin A excites the rat olivary pretectal nucleus via OX2 receptor in a daily manner

Brain Research ◽

10.1016/j.brainres.2021.147603 ◽

2021 ◽

pp. 147603

Author(s):

Lukasz Chrobok ◽

Anna Alwani ◽

Kamil Pradel ◽

Jasmin Daniela Klich ◽

Marian Henryk Lewandowski

Keyword(s):

Orexin A ◽

Pretectal Nucleus

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