Estimated ventricle size using Evans index: reference values from a population-based sample

We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease.Spirometry data collected in 30 239 subjects (51.7% females) aged 12–90 years in three population-based studies were converted to z-scores.We studied healthy non-smokers comprising 2438 adults (57.4% females) aged 20–90 years and 8725 (47.7% female) adolescents aged 12–19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median±sd z-scores were respectively 0.02±1.03, 0.01±1.04 and −0.04±0.91 for forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC in males, and −0.01±1.02, 0.07±0.97 and −0.21±0.82 in females. The ECSC and Zapletal references significantly underestimated FEV1 and FVC. Stricter criteria of obstruction (FEV1/FVC <GLI-2012 lower limit of normal (LLN)) carried a substantially higher risk of obstructive characteristics than FEV1/FVC <0.7 and >GLI-2012 LLN. Corresponding comparison regarding myocardial infarction showed a four-fold higher risk for women.The GLI-2012 reference values fit the Norwegian data satisfactorily and are recommended for use in Norway. Correspondingly, the FEV1/FVC GLI-2012 LLN identifies higher risk of obstructive characteristics than FEV1/FVC <0.7.

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REFERENCE VALUES FOR KNEE EXTENSION STRENGTH OBTAINED BY HAND-HELD DYNAMOMETRY FROM APPARENTLY HEALTHY OLDER ADULTS: A META-ANALYSIS

Journal of Frailty & Aging ◽

10.14283/jfa.2017.32 ◽

2017 ◽

pp. 1-3

Author(s):

R.W. Bohannon

Keyword(s):

Reference Values ◽

Meta Analysis ◽

Large Population ◽

Population Based ◽

Knee Extension ◽

Healthy Older Adults ◽

Hand Search ◽

Knee Extension Strength ◽

Old Men ◽

Summary Data

Normative reference values for knee extension strength obtained by hand-held dynamometry from adults 60 to 79 years were derived using summary data from 3 studies. The studies, which were identified through PubMed and a hand-search, contributed data from between 3 and 29 individuals for each age, gender, and side stratum. Meta-analysis was employed to consolidate knee extension strength data. Strength, normalized against body weight, ranged 35.6% for the nondominant side of 70 to 79 year old women to 48.8% for the nondominant side of 60 to 69 year old men. These values are more informative than those previously published in individual studies. However, reference values derived from a large population-based sample are needed.

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P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

European Heart Journal ◽

10.1093/eurheartj/ehz746.0280 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

C Xia ◽

M Rook ◽

G J Pelgrim ◽

J N Van Bolhuis ◽

P M A Van Ooijen ◽

...

Keyword(s):

Coronary Artery ◽

Reference Values ◽

Coronary Artery Calcium ◽

Adult Population ◽

Age Groups ◽

Population Based ◽

Imaging Biomarkers ◽

Dutch Population ◽

Age And Gender ◽

And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

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Reference Values of Maximal Respiratory Mouth Pressures: A Population-based Study

American Review of Respiratory Disease ◽

10.1164/ajrccm/146.3.790 ◽

1992 ◽

Vol 146 (3) ◽

pp. 790-793 ◽

Cited By ~ 94

Author(s):

Claudio Bruschi ◽

Isa Cerveri ◽

Maria C. Zoia ◽

Francesco Fanfulla ◽

Marilina Fiorentini ◽

...

Keyword(s):

Reference Values ◽

Population Based ◽

Population Based Study

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[OP.5B.03] POPULATION-BASED REFERENCE VALUES FOR PULSATILE HEMODYNAMICS IN MIDDLE-AGED AND ELDERLY INDIVIDUALS – RESULTS OF THE HEINZ NIXDORF RECALL STUDY

Journal of Hypertension ◽

10.1097/01.hjh.0000491484.36380.82 ◽

2016 ◽

Vol 34 ◽

pp. e57

Author(s):

T. Weber ◽

S. Wassertheurer ◽

B. Hametner ◽

S. Parragh ◽

S. Moebus ◽

...

Keyword(s):

Reference Values ◽

Population Based ◽

Middle Aged ◽

Elderly Individuals ◽

Heinz Nixdorf Recall Study

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Population-based reference values for lecithin-cholesterol acyltransferase (LCAT)

Atherosclerosis ◽

10.1016/0021-9150(82)90036-3 ◽

1982 ◽

Vol 43 (2-3) ◽

pp. 369-379 ◽

Cited By ~ 53

Author(s):

John J. Albers ◽

Robert O. Bergelin ◽

Janet L. Adolphson ◽

Patricia W. Wahl

Keyword(s):

Reference Values ◽

Cholesterol Acyltransferase ◽

Population Based ◽

Lecithin Cholesterol Acyltransferase

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Inherent biological variation and reference values

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2004.128 ◽

2004 ◽

Vol 42 (7) ◽

Cited By ~ 114

Author(s):

Callum G. Fraser

Keyword(s):

Reference Values ◽

Laboratory Data ◽

Population Based ◽

Biological Variation ◽

Specific Reference ◽

Theoretical Concepts ◽

Practical Applications ◽

Medical Laboratories ◽

Clinical Purpose ◽

Traditional Population

AbstractThere is a need for revisiting theoretical concepts and practical applications of conventional population-based reference values to make for better clinical use of laboratory data. Knowledge of the underlying biological variation of quantities examined in medical laboratories is vital to understanding the proper generation and application of traditional population-based reference values. Appreciation of the biological changes that occur over the span of life is a necessary prerequisite to deciding whether stratification of reference values according to age is likely to be necessary. Knowledge of the detail of predictable biological cyclical rhythms is required for correct clinical interpretation of laboratory data and appropriate collection of specimens at times relevant to the clinical purpose. Quantitative data on inherent within- and between-subject biological components of variation have shown the marked individuality of most quantities of interest in laboratory medicine. This individuality casts light on why examinations are not generally very successfully applied in population screening or case-finding. Consideration of individuality demonstrates why stratification of reference values is often very advantageous. Individuality provides an indisputable argument for better use of individual specific reference values.

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