Plasma neurofilament light chain levels and cognitive testing as predictors of fast progression in Alzheimer’s disease

2021 ◽  
Author(s):  
Roberto Santangelo ◽  
Federica Agosta ◽  
Francesco Masi ◽  
Edoardo Gioele Spinelli ◽  
Giordano Cecchetti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Light Chain ◽  
Cognitive Testing ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Fast Progression

O3-09-05: PLASMA TAU AND NEUROFILAMENT LIGHT CHAIN AS A PROGNOSTIC BIOMARKER OF DISEASE PROGRESSION IN EARLY ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_19) ◽  
pp. P1038-P1039
Author(s):  
Holly Soares ◽  
Sheng Feng ◽  
Hana Florian ◽  
Michael Gold ◽  
Hoi-Kei Lon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Light Chain ◽  
Prognostic Biomarker ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Early Alzheimer’S Disease

scholarly journals Diagnostic accuracy of CSF neurofilament light chain protein in the biomarker-guided classification system for Alzheimer's disease

2017 ◽  
Vol 108 ◽  
pp. 355-360 ◽  
Author(s):  
Simone Lista ◽  
Nicola Toschi ◽  
Filippo Baldacci ◽  
Henrik Zetterberg ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diagnostic Accuracy ◽  
Light Chain ◽  
Classification System ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals Tracking neurodegeneration in frontotemporal dementia and Alzheimer’s disease: A comparative study of plasma tau and neurofilament light chain

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Ignacio Illán‐Gala ◽  
Alberto Lleó ◽  
Anna M. Karydas ◽  
Adam M. Staffaroni ◽  
Henrik Zetterberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Comparative Study ◽  
Frontotemporal Dementia ◽  
Light Chain ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

[P1-287]: DIAGNOSTIC ACCURACY OF CSF NEUROFILAMENT LIGHT CHAIN PROTEIN IN THE UNBIASED BIOMARKER-GUIDED CLASSIFICATION SYSTEM FOR ALZHEIMER's DISEASE

2017 ◽  
Vol 13 (7S_Part_7) ◽  
pp. P361-P361
Author(s):  
Simone Lista ◽  
Nicola Toschi ◽  
Filippo Baldacci ◽  
Kaj Blennow ◽  
Henrik Zetterberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diagnostic Accuracy ◽  
Light Chain ◽  
Classification System ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals ATN classifications in a mixed cohort of frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD) pathology using cerebrospinal fluid neurofilament light chain (NFL)

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Katheryn Alexandra Quilico Cousins ◽  
Jeffrey S. Phillips ◽  
David J. Irwin ◽  
Eddie B. Lee ◽  
David A. Wolk ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

2020 ◽  
Vol 142 ◽  
pp. 104960 ◽  
Author(s):  
Stephanie A. Schultz ◽  
Jeremy F. Strain ◽  
Adedamola Adedokun ◽  
Qing Wang ◽  
Oliver Preische ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Light Chain ◽  
Autosomal Dominant ◽  
White Matter Integrity ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Autosomal Dominant Alzheimer’S Disease

scholarly journals Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease

Brain ◽  
2020 ◽  
Author(s):  
Joana B Pereira ◽  
Shorena Janelidze ◽  
Rik Ossenkoppele ◽  
Hlin Kvartsberg ◽  
Ann Brinkmalm ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Light Chain ◽  
Diffusion Tensor ◽  
Amyloid Β ◽  
Synaptic Function ◽  
Dependent Manner ◽  
Tau Pathology ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

Abstract It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic function and axonal structure over the course of Alzheimer’s disease. Here, we assessed these relationships by measuring presynaptic (synaptosomal-associated protein 25, SNAP25; growth-associated protein 43, GAP43), postsynaptic (neurogranin, NRGN) and axonal (neurofilament light chain) markers in the CSF of individuals with varying levels of amyloid-β and tau pathology based on 18F-flutemetamol PET and 18F-flortaucipir PET. In addition, we explored the relationships between synaptic and axonal markers with cognition as well as functional and anatomical brain connectivity markers derived from resting-state functional MRI and diffusion tensor imaging. We found that the presynaptic and postsynaptic markers SNAP25, GAP43 and NRGN are elevated in early Alzheimer’s disease i.e. in amyloid-β-positive individuals without evidence of tau pathology. These markers were associated with greater amyloid-β pathology, worse memory and functional changes in the default mode network. In contrast, neurofilament light chain was abnormal in later disease stages, i.e. in individuals with both amyloid-β and tau pathology, and correlated with more tau and worse global cognition. Altogether, these findings support the hypothesis that amyloid-β and tau might have differential downstream effects on synaptic and axonal function in a stage-dependent manner, with amyloid-related synaptic changes occurring first, followed by tau-related axonal degeneration.

scholarly journals Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease

2020 ◽  
Author(s):  
Min Su Kang ◽  
◽  
Arturo Aliaga Aliaga ◽  
Monica Shin ◽  
Sulantha Mathotaarachchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Light Chain ◽  
Brain Atrophy ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals Serum neurofilament light chain rate of change in Alzheimer’s disease: potentials applications and notes of caution

2019 ◽  
Vol 7 (S3) ◽  
pp. S133-S133 ◽  
Author(s):  
Federico Massa ◽  
Riccardo Meli ◽  
Silvia Morbelli ◽  
Flavio Nobili ◽  
Matteo Pardini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Light Chain ◽  
Rate Of Change ◽  
Neurofilament Light Chain ◽  
Neurofilament Light
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