Serial DaT‐SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8‐years follow‐up

2021 ◽  
Author(s):  
Antonio Sánchez‐Rodríguez ◽  
Isabel Martínez‐Rodríguez ◽  
Pascual Sánchez‐Juan ◽  
María Sierra ◽  
Isabel González‐Aramburu ◽  
...  
Keyword(s):  
Spect Imaging ◽  
Asymptomatic Carriers ◽  
G2019s Mutation ◽  
Lrrk2 G2019s ◽  
Dat Spect

scholarly journals Prospective clinical and DaT-SPECT imaging in premotor LRRK2 G2019S-associated Parkinson disease

Neurology ◽  
2017 ◽  
Vol 89 (5) ◽  
pp. 439-444 ◽  
Author(s):  
María Sierra ◽  
Isabel Martínez-Rodríguez ◽  
Pascual Sánchez-Juan ◽  
Isabel González-Aramburu ◽  
Mikel Jiménez-Alonso ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Rating Scale ◽  
Area Under The Curve ◽  
Region Of Interest ◽  
High Sensitivity ◽  
Spect Imaging ◽  
Imaging Biomarkers ◽  
Asymptomatic Carriers ◽  
G2019s Mutation ◽  
Dat Spect

Objective:To assess the value of baseline clinical and imaging biomarkers in a cohort of asymptomatic LRRK2 G2019S carriers for predicting conversion to Parkinson disease (PD) at 4 years.Methods:Thirty-two asymptomatic carriers of LRRK2 G2019S mutation underwent baseline and 4-year evaluation including clinical examination (Unified Parkinson's Disease Rating Scale, part III, olfaction University of Pennsylvania Smell Identification Test [UPSIT]) and dopamine transporter (DaT) SPECT (123I-ioflupane). Visual and semiquantitative analysis of images was performed. The specific striatal binding ratio was calculated (striatal region of interest [ROI] − occipital ROI/occipital ROI).Results:Three carriers, asymptomatic at baseline, had converted to PD at 4-year evaluation. Twenty-three participants were fully evaluated. PD converters had lower striatal DaT binding at baseline than nonconverters (p = 0.002). A baseline scan with a ratio of bilateral striatal uptake below 1 predicted conversion to PD within the 4-year period with high sensitivity and specificity (area under the curve 1; p = 0.006). The slope of DaT binding decline between the 2 scans was similar in PD converters and nonconverters. Age-adjusted UPSIT score at baseline and at 4 years was similar in both groups.Conclusions:Semiquantitative DaT-SPECT could be used to predict early conversion to PD in asymptomatic carriers of the LRRK2 G2019S mutation. Rate of conversion to PD at 4 years in this cohort aged ∼64 years was 12%. The slope of DaT binding decline on DaT-SPECT imaging seems to be similar across different stages of the premotor period.

Epidemiology, diagnosis, treatment and follow-up of cystic echinococcosis in asymptomatic carriers

2018 ◽  
Vol 113 (2) ◽  
pp. 74-80 ◽  
Author(s):  
Edmundo Larrieu ◽  
Leonardo Uchiumi ◽  
Juan Carlos Salvitti ◽  
Mariano Sobrino ◽  
Oscar Panomarenko ◽  
...  
Keyword(s):  
Cystic Echinococcosis ◽  
Asymptomatic Carriers

DAT-SPECT imaging in cases of drug-induced parkinsonism in a specialty movement disorders practice

2018 ◽  
Vol 53 ◽  
pp. 37-41 ◽  
Author(s):  
Jacob Yomtoob ◽  
Kimberly Koloms ◽  
Danny Bega
Keyword(s):  
Movement Disorders ◽  
Spect Imaging ◽  
Drug Induced ◽  
Dat Spect

Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease

2006 ◽  
Vol 21 (8) ◽  
pp. 1232-1235 ◽  
Author(s):  
Roberta Marongiu ◽  
Daniele Ghezzi ◽  
Tamara Ialongo ◽  
Francesco Soleti ◽  
Antonio Elia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
G2019s Mutation ◽  
Lrrk2 G2019s

SPECT imaging of the brain in dementia: Follow-up evaluation

1992 ◽  
Vol 13 ◽  
pp. S21-S22
Keyword(s):  
Spect Imaging ◽  
The Brain

Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease?

Neurology ◽  
2008 ◽  
Vol 71 (19) ◽  
pp. 1550-1552 ◽  
Author(s):  
S. Lesage ◽  
S. Belarbi ◽  
A. Troiano ◽  
C. Condroyer ◽  
N. Hecham ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
North African ◽  
G2019s Mutation ◽  
Lrrk2 G2019s ◽  
The Common

scholarly journals LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Insup Choi ◽  
Beomsue Kim ◽  
Ji-Won Byun ◽  
Sung Hoon Baik ◽  
Yun Hyun Huh ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
G2019s Mutation ◽  
Lrrk2 G2019s
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