LMR‐101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ‐aminobutyric acid type A receptors

Yi Zhao; Long An; Shupan Guo; Xiaoxing Huang; Huajie Tian; Li Liu; Tao Chen; Xun Sun; Qibing Mei; Rutao Wang

doi:10.1111/epi.16757

LMR‐101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ‐aminobutyric acid type A receptors

Epilepsia ◽

10.1111/epi.16757 ◽

2021 ◽

Vol 62 (1) ◽

pp. 238-249

Author(s):

Yi Zhao ◽

Long An ◽

Shupan Guo ◽

Xiaoxing Huang ◽

Huajie Tian ◽

...

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Acid Type ◽

Novel Target ◽

Anticonvulsant Effects

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Faculty Opinions recommendation of Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1059787.511720 ◽

2007 ◽

Author(s):

M Bruce MacIver

Keyword(s):

Minimum Alveolar Concentration ◽

Type A ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Inhaled Anesthetics ◽

Acid Type ◽

Righting Reflex

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Faculty Opinions recommendation of Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158389.621642 ◽

2009 ◽

Author(s):

Edward Bertaccini

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Acid Type

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Faculty Opinions recommendation of Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14239956.15757056 ◽

2012 ◽

Author(s):

Stan Leung ◽

Tao Luo

Keyword(s):

Recognition Memory ◽

General Anesthesia ◽

Type A ◽

Aminobutyric Acid ◽

Acid Type

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Faculty Opinions recommendation of Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717993480.793477359 ◽

2013 ◽

Author(s):

Vesna Jevtovic-Todorovic

Keyword(s):

Axon Guidance ◽

Type A ◽

Aminobutyric Acid ◽

Neocortical Neurons ◽

Acid Type

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Faculty Opinions recommendation of Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718010634.793483802 ◽

2013 ◽

Author(s):

Edward Bertaccini

Keyword(s):

Gabaa Receptor ◽

Binding Sites ◽

Transmembrane Domain ◽

Type A ◽

Aminobutyric Acid ◽

General Anesthetic ◽

Acid Type

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Faculty Opinions recommendation of Synergistic Modulation of γ-Aminobutyric Acid Type A Receptor-Mediated Synaptic Inhibition in Cortical Networks by Allopregnanolone and Propofol.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726644026.793531387 ◽

2017 ◽

Author(s):

Paul Davies

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Synaptic Inhibition ◽

Cortical Networks ◽

Acid Type ◽

Synergistic Modulation

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Faculty Opinions recommendation of Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726858006.793525093 ◽

2016 ◽

Author(s):

Roderic Eckenhoff ◽

Kellie Woll

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Intravenous Anesthetics ◽

Acid Type

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[11C]Flumazenil Positron Emission Tomography Analyses of Brain Gamma-Aminobutyric Acid Type A Receptors in Angelman Syndrome

The Journal of Pediatrics ◽

10.1016/j.jpeds.2007.08.038 ◽

2008 ◽

Vol 152 (4) ◽

pp. 546-549.e3 ◽

Cited By ~ 12

Author(s):

Naoko Asahina ◽

Tohru Shiga ◽

Kiyoshi Egawa ◽

Hideaki Shiraishi ◽

Shinobu Kohsaka ◽

...

Keyword(s):

Positron Emission Tomography ◽

Angelman Syndrome ◽

Type A ◽

Emission Tomography ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Positron Emission ◽

Acid Type

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Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(20)80569-9 ◽

1993 ◽

Vol 268 (29) ◽

pp. 21505-21508

Author(s):

M Xu ◽

M.H. Akabas

Keyword(s):

Amino Acids ◽

Type A ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Cysteine Substitution ◽

Acid Type

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Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02163 ◽

2021 ◽

Author(s):

Frederik Rostrup ◽

Christina B. Falk-Petersen ◽

Kasper Harpso̷e ◽

Stine Buchleithner ◽

Irene Conforti ◽

...

Keyword(s):

Mode Of Action ◽

Type A ◽

Aminobutyric Acid ◽

Structural Determinants ◽

Acid Type

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