Hair growth-promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β-catenin and MAPK pathway

2015 ◽  
Vol 24 (12) ◽  
pp. 958-963 ◽  
Author(s):  
Ki Min Sohn ◽  
Kwan Ho Jeong ◽  
Jung Eun Kim ◽  
Young Min Park ◽  
Hoon Kang
Keyword(s):  
Hair Growth ◽  
Growth Promotion ◽  
Mapk Pathway ◽  
Alternating Current ◽  
Current Parameter

scholarly journals Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

2021 ◽  
Vol 12 ◽  
Author(s):  
Jawaria Iltaf ◽  
Sobia Noreen ◽  
Muhammad Fayyaz ur Rehman ◽  
Shazia Akram Ghumman ◽  
Fozia Batool ◽  
...  
Keyword(s):  
In Silico ◽  
Hair Growth ◽  
De Novo ◽  
Growth Promotion ◽  
Hair Follicles ◽  
Binding Energies ◽  
Ficus Benghalensis ◽  
Rp Hplc

The screening of hair follicles, dermal papilla cells, and keratinocytes through in vitro, in vivo, and histology has previously been reported to combat alopecia. Ficus benghalensis has been used conventionally to cure skin and hair disorders, although its effect on 5α-reductase II is still unknown. Currently, we aim to analyze the phytotherapeutic impact of F. benghalensis leaf extracts (FBLEs) for promoting hair growth in rabbits along with in vitro inhibition of the steroid isozyme 5α-reductase II. The inhibition of 5α-reductase II by FBLEs was assessed by RP-HPLC, using the NADPH cofactor as the reaction initiator and Minoxin (5%) as a positive control. In silico studies were performed using AutoDock Vina to visualize the interaction between 5α-reductase II and the reported phytoconstituents present in FBLEs. Hair growth in female albino rabbits was investigated by applying an oral dose of the FBLE formulation and control drug to the skin once a day. The skin tissues were examined by histology to see hair follicles. Further, FAAS, FTIR, and antioxidants were performed to check the trace elements and secondary metabolites in the FBLEs. The results of RP-HPLC and the binding energies showed that FBLEs reduced the catalytic activity of 5α-reductase II and improved cell proliferation in rabbits. The statistical analysis (p < 0.05 or 0.01) and percentage inhibition (>70%) suggested that hydroalcoholic FBLE has more potential in increasing hair growth by elongating hair follicle’s anagen phase. FAAS, FTIR, and antioxidant experiments revealed sufficient concentrations of Zn, Cu, K, and Fe, together with the presence of polyphenols and scavenging activity in FBLE. Overall, we found that FBLEs are potent in stimulating hair follicle maturation by reducing the 5α-reductase II action, so they may serve as a principal choice in de novo drug designing to treat hair loss.

scholarly journals Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-clinical Study Using Phototrichogram Analysis

Cosmetics ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 66
Author(s):  
Hyoung Chul Choi ◽  
Gae Won Nam ◽  
Noh Hee Jeong ◽  
Bu Young Choi
Keyword(s):  
Clinical Study ◽  
Hair Loss ◽  
Hair Growth ◽  
Blood Circulation ◽  
Growth Promotion ◽  
Test Group ◽  
Androgenetic Alopecia ◽  
Hair Density ◽  
Caesalpinia Sappan ◽  
Inula Helenium

Inula helenium (IH) is known to possess antifungal, anti-bacterial, anti-helminthic, and anti-proliferation activities. Caesalpinia Sappan (CS) is known to reduce inflammation and improve blood circulation. Based on their folkloric use, these plants are expected to be promising candidates for promoting hair growth and preventing hair loss. Moreover, these plants are rich sources of certain phytochemicals, which have been reported to promote hair growth. In this clinical trial, we investigate the efficacy of a scalp shampoo formulated by mixing extracts of IH and CS in preventing hair loss and promoting hair growth in patients with androgenetic alopecia. Using a phototrichogram (Folliscope 2.8, LeadM, Korea), we compared the hair density and total hair counts in patients receiving the scalp shampoo at baseline, and at 8, 16, and 24 weeks after use of the shampoo. We found a statistically significant increase in the total hair count in the test group (n = 23) after 16 and 24 weeks of using the scalp shampoo (2.17 n/cm2 ± 5.72, p < 0.05; and 4.30 n/cm2 ± 6.37, p < 0.01, respectively) as compared to the control subjects. Based on the results of this clinical study, we conclude that the IH and CS extract complex is a promising remedy for preventing hair loss and promoting hair growth.

scholarly journals Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 42170-42178 ◽  
Author(s):  
Yan Zhang ◽  
Jie-wen Wang ◽  
Fan-zhi Qu ◽  
Yu-meng Zhang ◽  
Guang-yue Su ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Hair Loss ◽  
Hair Growth ◽  
Growth Promotion ◽  
Promotion Effect

Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss.

In Vivo Hair Growth Promotion Activity of Gel Containing Niosomes Loaded with the Oryza sativa Bran Fraction (OSF3)

2012 ◽  
Vol 16 (1) ◽  
pp. 222-228 ◽  
Author(s):  
Aranya Manosroi ◽  
Warintorn Ruksiriwanich ◽  
Worapaka Manosroi ◽  
Masahiko Abe ◽  
Jiradej Manosroi
Keyword(s):  
Oryza Sativa ◽  
Hair Growth ◽  
Growth Promotion ◽  
Promotion Activity

scholarly journals Minoxidil-Containing Dosage Forms: Skin Retention and After-Rinsing Hair-Growth Promotion

Drug Delivery ◽  
2003 ◽  
Vol 10 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Jin-Chul Kim ◽  
Min-Ho Lee ◽  
Moon-Jeong Rang
Keyword(s):  
Hair Growth ◽  
Growth Promotion ◽  
Dosage Forms ◽  
Skin Retention

5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment

2012 ◽  
Vol 139 (3) ◽  
pp. 765-771 ◽  
Author(s):  
Naphatsorn Kumar ◽  
Wandee Rungseevijitprapa ◽  
Nual-Anong Narkkhong ◽  
Maitree Suttajit ◽  
Chaiyavat Chaiyasut
Keyword(s):  
Hair Growth ◽  
Growth Promotion

scholarly journals Comparative Hair Restorer Efficacy of Medicinal Herb on Nude (Foxn1nu) Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Shahnaz Begum ◽  
Mi Ra Lee ◽  
Li Juan Gu ◽  
Md. Jamil Hossain ◽  
Hyun Kyoung Kim ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Nude Mice ◽  
Hair Loss ◽  
Hair Growth ◽  
Growth Promotion ◽  
Hair Follicles ◽  
Growth Potential ◽  
Eclipta Alba ◽  
Growth Area ◽  
Brdu Labeling

Eclipta alba(L.) Hassk,Asiasarum sieboldii(Miq.) F. Maek (Asiasari radix), andPanax ginsengC. A. Mey (red ginseng) are traditionally acclaimed for therapeutic properties of various human ailments. Synergistic effect of each standardized plant extract was investigated for hair growth potential on nude mice, as these mutant mice genetically lack hair due to abnormal keratinization. Dried plant samples were ground and extracted by methanol. Topical application was performed on the back of nude mice daily up to completion of two hair growth generations. The hair density and length ofEclipta albatreated mice were increased significantlyP>0.001than control mice. Hair growth area was also distinctly visible inEclipta albatreated mice. On the other hand,Asiasari radixandPanax ginsengtreated mice developing hair loss were recognized from the abortive boundaries of hair coverage. Histomorphometric observation of nude mice skin samples revealed an increase in number of hair follicles (HFs). The presence of follicular keratinocytes was confirmed by BrdU labeling, S-phase cells in HFs. Therefore,Eclipta albaextract and/or phytochemicals strongly displayed incomparability of hair growth promotion activity than others. Thus, the standardizedEclipta albaextract can be used as an effective, alternative, and complementary treatment against hair loss.

scholarly journals Assessment of Hair Growth Treatment with the Consciousness Energy Healing Treated Williams Medium E Using Mouse Vibrissae Hair Follicle Organ Culture

2019 ◽  
Vol 1 (3) ◽  
pp. 12-19
Author(s):  
Mahendra Kumar Trivedi ◽  
Snehasis Jana
Keyword(s):  
Organ Culture ◽  
Hair Follicle ◽  
Test Item ◽  
Hair Growth ◽  
Sexual Communication ◽  
Growth Promotion ◽  
Growth Promoter ◽  
Energy Healing ◽  
Hair Follicle Organ Culture

Hair is playing an interesting part in human for social and sexual communication. Loss of hair follicle leads to various skin disorders. For this consequence, the present study has investigated the potential of the Biofield Energy Healing (The Trivedi Effect®) Treated test item (William’s Medium E) on the vibrissae hair follicle organ culture cells for the assessment of hair cell growth and development in vitro. The test item was divided into two parts. One part was defined as the untreated test item, where no Biofield Energy Treatment provided, while the other part was defined as the Biofield Energy Treated test item, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Mahendra Kumar Trivedi. The study parameters like bulb thickness and formation of telogen were assessed using cell-based assay with the help of UTHSCSA Image tool version 3. The experimental results showed that the untreated test item group showed 20.9% and 28.2% increased bulb thickness on day 5 and 7, respectively compared to the day 1, while did not produce telogen follicles upto day 7. Besides, the percentage of telogen follicle was found as 43%, 57%, and 71% on day 3, 5, and 7, respectively of the Biofield Energy Treated test item group compared to the day 1. The overall results demonstrated that the Biofield Energy Treatment has the potential for hair growth promotion as evident via increased the formation of telogen. Therefore, the Biofield Energy Healing (The Trivedi Effect®) Treatment might be useful as a hair growth promoter for various treatment of skin injuries and skin-related disorders like necrotizing fasciitis, actinic keratosis, sebaceous cysts, diaper rash, decubitus ulcer etc.

scholarly journals Evaluation of hair growth promotion

1992 ◽  
Vol 37 (4) ◽  
pp. 595-600 ◽  
Author(s):  
MICHIHIRO HATTORI
Keyword(s):  
Hair Growth ◽  
Growth Promotion
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