5‐Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8

2021 ◽  
Author(s):  
Linglin Zhang ◽  
Jiayi Yang ◽  
Xiaojing Liu ◽  
Detian Xu ◽  
Lei Shi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Inflammatory Response ◽  
Acne Vulgaris ◽  
Aminolaevulinic Acid

ALA-PDT Amplifies Intense Inflammatory Response in the Treatment of Acne Vulgaris via CXCL8

2020 ◽  
Author(s):  
Lingling Zhang ◽  
Jiayi Yang ◽  
Xiaojing Liu ◽  
Detian Xu ◽  
Lei Shi ◽  
...  
Keyword(s):  
T Cells ◽  
Photodynamic Therapy ◽  
Inflammatory Response ◽  
Acne Vulgaris ◽  
Specific Mechanism ◽  
Lipid Secretion ◽  
Severe Acne ◽  
P38 Pathway

Abstract Background: Acne vulgaris is a chronic inflammatory cutaneous disease. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is a novel and effective therapy for severe acne vulgaris. However, the specific mechanism of ALA-PDT for acne still remain unclear. Here, we investigate the possible mechanism of intense inflammatory response of ALA-PDT for acne vulgaris. Results: It appeared that ALA-PDT suppresses proliferation and lipid secretion of primary human sebocytes. And ALA-PDT could up-regulate the expression of CXCL8 in vivo and in vitro, amplifying inflammatory response by recruiting T cells, B cells, neutrophils and macrophages. We also found that ALA-PDT elevated the expression of CXCL8 via p38 pathway. SB203580, a p38 pathway inhibitor, decreased the expression of CXCL8 after ALA-PDT in sebocytes. Conclusion: ALA-PDT amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8. Our data deciphers the mechanism of intense inflammatory response after ALA-PDT for acne vulgaris.

Peptide-targeted prodrugs for aminolaevulinic acid photodynamic therapy

2017 ◽  
Vol 17 ◽  
pp. A60
Author(s):  
K.M. Tewari ◽  
E. Yaghini ◽  
O. Reelfs ◽  
R. Dondi ◽  
C. Pourzand ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aminolaevulinic Acid

Photodynamic therapy of sebaceous hyperplasia with topical 5-aminolaevulinic acid and slide projector

2003 ◽  
Vol 148 (6) ◽  
pp. 1274-1276 ◽  
Author(s):  
T. Horio ◽  
O. Horio ◽  
H. Miyauchi-Hashimoto ◽  
M. Ohnuki ◽  
T. Isei
Keyword(s):  
Photodynamic Therapy ◽  
Slide Projector ◽  
Aminolaevulinic Acid
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