Management of coronary artery disease and acute coronary syndrome in the chronic kidney disease population-A review of the current literature

2017 ◽  
Vol 21 (4) ◽  
pp. 472-482 ◽  
Author(s):  
Justin M. Lingel ◽  
Mukta C. Srivastava ◽  
Anuj Gupta
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Current Literature ◽  
Coronary Syndrome ◽  
Chronic Kidney Disease Population ◽  
Artery Disease

Abstract 3711: Increased Expression of Plasma Granzyme B in the Patients with Coronary Artery Disease Complicated with Chronic Kidney Disease

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Tomokazu Ikemoto ◽  
Yukihiro Hojo ◽  
Hideyuki Kondo ◽  
Nozomu Takahashi ◽  
Masahiro Hirose ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Inflammatory Diseases ◽  
Granzyme B ◽  
Significant Negative Correlation ◽  
Coronary Syndrome ◽  
Significant Independent Risk Factor ◽  
Artery Disease

Background: Recent clinical studies have revealed that chronic kidney disease (CKD) is a significant independent risk factor for major cardiovascular events. However, the mechanisms in which CKD increases the incidence of cardiovascular diseases are still not fully understood. Hypothesis: Granzyme B is a member of serine protease family released from cytotoxic T lymphocytes and plays an important role in cellular apoptosis via an activation of caspases. We hypothesized that granzyme B is involved in formation of coronary artery lesions in patients with CKD. Objectives: To elucidate the role of granzyme B in coronary artery disease (CAD) in patients complicated with CKD. Subjects and methods: We employed 141 patients (116 men and 25 women, mean age: 64.2±9.6 years old ). Diagnosis of CAD was confirmed by selective coronary angiography. CKD was defined as sustained decrease in estimated glomerular filtration rate less than 60 mL/min/1.73m 2 over 3 months. We assigned patients into three groups; CAD without CKD (CAD group, n=46), CKD without CAD (CKD group, n=17) and CAD with CKD (CAD/CKD group, n=78). Patients with acute coronary syndrome, immunological disorder, malignancy and acute inflammatory diseases were excluded from the study. Results: Analysis of variance showed that plasma levels of high-sensitive CRP (hsCRP) and granzyme B in CAD/CKD group were significantly higher than those in the other groups (hsCRP: CAD; 2420±763, CKD; 1802±584, CAD/CKD: 7419±2171 ng/mL, p<0.05, granzyme B: CAD: 9.1±2.3, CKD: 42.2±2.4, CAD/CKD: 159±51.8 pg/mL, p<0.01). A significant positive correlation was observed between plasma hsCRP and granzyme B levels (r=+0.30, p<0.05). A significant negative correlation was observed between eGFR and granzyme B levels (r=−0.32, p<0.01). Multiple regression analysis revealed that granzyme B and hs CRP levels were independent predicting variables for the number of stenosis in major coronary arteries (F=5.35, p=0.002, beta coefficients: granzyme B=+0.24, p=0.006, hsCRP=+0.18, p=0.03). Conclusions: These results indicate that granzyme B might be a critical enzyme for formation of coronary atherosclerosis by inducing apoptosis of vascular tissues in patients with CKD.

Study on Vitamin D deficiency in patients of diabetes mellitus presenting with Acute Coronary syndrome in a tertiary care hospital in South India

2020 ◽  
Vol 11 (5) ◽  
pp. 49-53
Author(s):  
Archana Bhat ◽  
Arunachalam Ramachandran ◽  
Pradeep Periera ◽  
Akshatha Rao Aroor
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Coronary Syndrome ◽  
Vitamin D Levels ◽  
Luminal Stenosis ◽  
Artery Disease

Background: Vitamin D, a fat-soluble vitamin has its receptor present in myriad of tissues and it modulates multiple cellular processes. Vitamin D deficiency is reported to be associated with coronary artery disease. Cardiovascular disease is the leading cause of mortality worldwide. Aims and Objective: The primary outcome was to investigate if there is a correlation of 25-OH levels with the percentage of luminal stenosis, as measured with coronary angiogram. The secondary outcome was to determine the differences in angiographically proven luminal stenosis across categories of 25-OH vitamin D levels. Materials and Methods: Thirty patients with acute coronary syndrome with diabetes mellitus were included in this cross-sectional descriptive study. All patients were tested for fasting vitamin D levels, fasting blood sugar, HbA1C and serum creatinine. Detailed history of the patients was recorded. Data was analyzed by the statistical software SPSS version 19 and p value <0.05 was considered significant. Statistical tests like Chi- square, independent t test and log regression was used. Results: In this study 30 patients undergoing coronary angiography for acute coronary syndrome, Vitamin D levels showed severe deficiency in 6.7% (2) cases while mild deficiency was seen in 50% of the cases. Patients with single vessel disease on the coronary angiogram had lower mean HbA1C (9.18) levels in our study. Patients with triple vessel disease had poorly controlled mean HbA1C levels (10.42). Conclusion: In this study we did not find any significant difference between the serum Vitamin D deficiency levels with patients with angiographic severity of the coronary artery disease. Patients with poorly controlled diabetes mellitus had more severe angiographic proven coronary artery disease.

scholarly journals Comparative Platelet Releasate Proteomic Profiling of Acute Coronary Syndrome versus Stable Coronary Artery Disease

2020 ◽  
Vol 7 ◽  
Author(s):  
Patricia B. Maguire ◽  
Martin E. Parsons ◽  
Paulina B. Szklanna ◽  
Monika Zdanyte ◽  
Patrick Münzer ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Proteomic Profiling ◽  
Coronary Syndrome ◽  
Platelet Releasate ◽  
Artery Disease

scholarly journals Severe Coronary Artery Disease in a Person Living with HIV

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 595
Author(s):  
Mircea Bajdechi ◽  
Cosmin Mihai ◽  
Alexandru Scafa-Udriste ◽  
Ali Cherry ◽  
Diana Zamfir ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Severe Coronary Artery Disease ◽  
Atypical Symptoms ◽  
Coronary Syndrome ◽  
Severe Coronary Artery ◽  
Artery Disease ◽  
Living With Hiv ◽  
Missed Diagnoses

The pathophysiology of accelerated atherosclerosis in people living with Human Immunofediciency virus (HIV) is complex. Coronary artery disease (CAD) has become an important cause of mortality in these patients. They often have atypical symptoms, leading to frequently missed diagnoses. We report a case of a 51-year-old male undergoing antiretroviral therapy who was admitted for acute coronary syndrome. He had severe coronary artery disease that involved difficult management.

scholarly journals CHRONIC KIDNEY DISEASE IS A TYPE 2 DIABETES RISK EQUIVALENT IN PATIENTS WITH ESTABLISHED CORONARY ARTERY DISEASE

2021 ◽  
Vol 77 (18) ◽  
pp. 1513
Author(s):  
Christoph H. Saely ◽  
Lukas Sprenger ◽  
Alexander Vonbank ◽  
Barbara Larcher ◽  
Arthur Mader ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Diabetes Risk ◽  
Established Coronary Artery Disease ◽  
Artery Disease ◽  
Risk Equivalent

scholarly journals 884-5 Impact of troponin status and coronary artery disease by angiography on outcome in acute coronary syndrome: A TACTICS TIMI-18 substudy

2004 ◽  
Vol 43 (5) ◽  
pp. A307
Author(s):  
Manu Pillai ◽  
Peter DiBattiste ◽  
Sabina Murphy ◽  
David Morrow ◽  
Christopher Cannon ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Syndrome ◽  
Artery Disease

Correlations between severity of coronary artery disease in patients diagnosed with Acute Coronary Syndrome and changes in local earth magnetic field

2021 ◽  
Author(s):  
Greta Ziubryte ◽  
Vilmantas Smalinskas ◽  
Laurynas Maciulevicius ◽  
Rollin McCraty ◽  
Alfonsas Vainoras ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Syndrome ◽  
Earth Magnetic Field ◽  
Artery Disease
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