Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia

Helicobacter ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. e12487 ◽  
Author(s):  
Sadaf Saghier ◽  
Steven M. Schwarz ◽  
Virginia Anderson ◽  
Raavi Gupta ◽  
Amin Heidarian ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Unique Pattern ◽  
Foveolar Hyperplasia

scholarly journals Inflammation and Foveolar Hyperplasia Are Reduced by Supplemental Dietary Glutamine during Helicobacter pylori Infection in Mice

2009 ◽  
Vol 139 (5) ◽  
pp. 912-918 ◽  
Author(s):  
Susan J. Hagen ◽  
Masa Ohtani ◽  
Jin-Rong Zhou ◽  
Nancy S. Taylor ◽  
Barry H. Rickman ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Foveolar Hyperplasia

scholarly journals Helicobacteriosis: changes of the mucosa in disorder of motor functions (motorics) in the gastroesophagal and duodenogastral zones of the stomach

2021 ◽  
Vol 65 (1) ◽  
pp. 96-102
Author(s):  
O. O. Yanovich ◽  
L. P. Titov ◽  
M. V. Doroshko ◽  
I. G. Sergeeva ◽  
S. A. Guzov
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Reflux Esophagitis ◽  
Morphological Changes ◽  
Duodenogastric Reflux ◽  
Study Group ◽  
Foveolar Hyperplasia ◽  
Increased Risk ◽  
H Pylori

The morphological changes in the gastric mucosa in the presence of duodenogastric reflux and refluxesophagitis and their connection with the presence of Helicobacter pylori (HP) infection are studied. The endoscopic and histological examination of the stomach antral part was performed in 1251 patients with different gastroduodenal pathologies. HP was diagnosed by histological and real-time PCR methods. Among patients with different gastroduodenal pathologies the frequency of H. pylori infection was 77.9 %. Duodenogastric reflux was detected in 23.9 % of patients. In the presence of duodenogastric reflux, we have found a decrease in the risk of duodenal ulcer by a factor of 2.5, thus duodenogastric reflux may protect against the development of duodenal ulcer. In patients with duodenogastric reflux in the presence of H. pylori infection, significant differences from the group uninfected of Helicobacter pylori were found in the metaplasia frequency. A significant increase in the frequency of foveolar hyperplasia among patients with duodenogastric reflux was revealed. The prevalence of reflux-esophagitis in the study group was 8.3 %. No increased risk in reflux-esophagitis was observed either in the HP-positive or HP-negative cases. According to our finding, duodenogastric reflux was characterized by foveolar hyperplasia and metaplasia. We suggest that the presence or absence of H. pylori does not affect reflux-esophagitis.

scholarly journals Evaluation of Lineage Changes in the Gastric Mucosa Following Infection With Helicobacter pylori and Specified Intestinal Flora in INS-GAS Mice

2018 ◽  
Vol 67 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Carolina Pinzon-Guzman ◽  
Anne R. Meyer ◽  
Rachel Wise ◽  
Eunyoung Choi ◽  
Sureshkumar Muthupalani ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Intestinal Flora ◽  
Gastric Lesions ◽  
Ulex Europaeus ◽  
Germ Free ◽  
Foveolar Hyperplasia ◽  
Intestinal Mucin ◽  
Spasmolytic Polypeptide ◽  
H Pylori ◽  
And Behavior

Gastric adenocarcinoma develops in metaplastic mucosa associated with Helicobacter pylori infection in the stomach. We have sought to evaluate the precise lineage changes in the stomachs of insulin-gastrin (INS-GAS) mice infected with H. pylori and/or intestinal flora (Altered Schaedler’s Flora; ASF). Stomachs from groups infected with H. pylori contained progressive spasmolytic polypeptide-expressing metaplasia (SPEM) compared with germ-free and mice infected with ASF alone. The overall phenotype of the H. pylori-infected mice was dominated by Ulex europaeus lectin (UEAI)-positive foveolar hyperplasia that was distinct from GSII/CD44v9-positive SPEM. However, in the mice with H. pylori co-infected with ASF, we identified a subpopulation of UEAI-positive foveolar cells that co-expressed intestinal mucin 4 (MUC4). These regions of foveolar cells were variably positive for CD44v9 as well as TFF3. Interestingly, an intravascular lesion identified in a dual H. pylori/ASF-infected mouse expressed both UEAI and Muc4. Finally, we identified an increase in the number of tuft cells within the mucosa of H. pylori-infected groups. Our findings suggest that H. pylori infection promotes foveolar hyperplasia as well as metaplasia, while co-infection may promote progressive foveolar and metaplastic lesions as well as dysplasia. Grading of gastric lesions in mice as preneoplastic requires multiple immunostaining markers to assign lineage derivation and behavior.

The rod-to-coccoid body transformation in cultures of Helicobacter pylori

1990 ◽  
Vol 48 (3) ◽  
pp. 626-627
Author(s):  
A. R. Crooker ◽  
W. G. Kraft ◽  
T. L. Beard ◽  
M. C. Myers
Keyword(s):  
Helicobacter Pylori ◽  
Growth Cycle ◽  
Negative Bacterium ◽  
Body Formation ◽  
Coccoid Form ◽  
Spiral Form ◽  
Prolonged Culture ◽  
H Pylori ◽  
Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

FUTURE RESEARCH AND TREATMENT IN HELICOBACTER PYLORI INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H22-H22
Author(s):  
David Y. Graham
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Future Research

CHARACTERISTIC OF GASTRIC CANCER IN INDONESIA: THE ROLE OF HELICOBACTER PYLORI INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H5-H5 ◽  
Author(s):  
Murdani Abdullah ◽  
A Aziz Rani ◽  
Daldiyono
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection

DYSPEPSIA SYNDROME AND HELICOBACTER PYLORI INFECTION IN END STAGE RENAL FAILURE

2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman
Keyword(s):  
Renal Failure ◽  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
End Stage Renal Failure ◽  
End Stage

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer

HEMATEMESIS AND MELENA IN BABY WITH HELICOBACTER PYLORI INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H10-H11
Author(s):  
Budi Purnomo ◽  
Eva J. Soeleman ◽  
Hadjat S. Digdowirogo ◽  
Hartati N. Soehardjo
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection

C14 UREA BREATH TEST DOES NOT CORRELATE WITH HELICOBACTER PYLORI INFECTION DENSITY IN GASTRIC MUCOSA

2000 ◽  
Vol 15 (12) ◽  
pp. H6-H6
Author(s):  
Dinesh Kumar ◽  
V. Ahuja ◽  
C.s Bal ◽  
S.d Gupta ◽  
M. Mathur ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Breath Test ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Infection Density
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