Comparative analysis of liver functional reserve during lenvatinib and sorafenib for advanced hepatocellular carcinoma

2020 ◽  
Vol 50 (7) ◽  
pp. 871-884 ◽  
Author(s):  
Takeshi Terashima ◽  
Tatsuya Yamashita ◽  
Noboru Takata ◽  
Tadashi Toyama ◽  
Tetsuro Shimakami ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Comparative Analysis ◽  
Advanced Hepatocellular Carcinoma ◽  
Functional Reserve ◽  
Liver Functional Reserve

Liver functional reserve and survival after sunitinib therapy in cirrhotic patients with advanced hepatocellular carcinoma.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e14600-e14600
Author(s):  
M. Biolato ◽  
M. Basso ◽  
A. Cassano ◽  
C. Cefalo ◽  
L. Miele ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Advanced Hepatocellular Carcinoma ◽  
Functional Reserve ◽  
Liver Functional Reserve ◽  
Cirrhotic Patients

Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: Prospects for regorafenib therapy

2018 ◽  
Vol 48 (12) ◽  
pp. 956-966 ◽  
Author(s):  
Takeshi Terashima ◽  
Tatsuya Yamashita ◽  
Hajime Sunagozaka ◽  
Kuniaki Arai ◽  
Kazunori Kawaguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Advanced Hepatocellular Carcinoma ◽  
Functional Reserve ◽  
Sorafenib Treatment ◽  
Liver Functional Reserve

Liver Damage after Transarterial Chemoembolization without Embolizing Agent in Unresectable Hepatocellular Carcinoma

2003 ◽  
Vol 89 (3) ◽  
pp. 285-287 ◽  
Author(s):  
Stefano Puleo ◽  
Letizia Mauro ◽  
Giuseppe Gagliano ◽  
Rosario Lombardo ◽  
Giovanni Li Destri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Alpha Fetoprotein ◽  
Total Serum ◽  
Advanced Hepatocellular Carcinoma ◽  
Significant Finding ◽  
Safe Procedure ◽  
Hepatic Functional Reserve ◽  
Neoplastic Tissue ◽  
Functional Reserve

Aim and Background Transarterial chemoembolization represents a therapy for hepatocellular carcinoma, but in cirrhotic patients affected by large or multifocal HCC with poor hepatic functional reserve, the procedure can damage normal parenchyma. We analyzed the effects on hepatic function of a modified chemoembolization consisting of ethiodized oil (Lipiodol Ultra Fluid) and epirubicin without gelatine sponge (C-LIP). Methods Of 90 patients with hepatocellular carcinoma observed from January 1995 to December 1999, 16 with a diagnosis of advanced (large or multifocal) disease underwent 19 C-LIP. The 30th post-C-LIP day was considered as a checkpoint of the biochemical parameters for a possible hepatic failure. The value of alpha-fetoprotein and the clinical finding of ascites were also considered after 30 days. Results Postoperative values of serum aspartate aminotrasferases, as well as alanine aminotransferase, were significantly higher than preoperative values (P = 0.002 and P = 0.019, respectively) (Table 1). In all patients, there was a significant increase in postoperative total serum bilirubin (P = 0.003). Statistical analysis showed a significant finding of postoperative ascites (P = 0.035) and the effectiveness of C-LIP on neoplastic tissue by a decrease of alpha-fetoprotein values at 30 days (P = 0.067). Conclusions Transcatether arterial chemoembolization could represent an effective therapy against multifocal or advanced hepatocellular carcinoma, and its effectiveness is probably not decreased by using a modified procedure without embolizing agent (C-LIP). However, even when performing such a safe procedure, the hepatic functional reserve of the individual patient needs to be accurately evaluated in order to avoid liver failure.

scholarly journals External Validation of Six Liver Functional Reserve Models to predict Posthepatectomy Liver Failure after Major Resection for Hepatocellular Carcinoma

2021 ◽  
Vol 12 (17) ◽  
pp. 5260-5267
Author(s):  
Guangmeng Guo ◽  
Zhengqing Lei ◽  
Xuewu Tang ◽  
Weihu Ma ◽  
Anfeng Si ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Failure ◽  
External Validation ◽  
Functional Reserve ◽  
Posthepatectomy Liver Failure ◽  
Liver Functional Reserve ◽  
Major Resection

scholarly journals Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247728
Author(s):  
Taku Shigesawa ◽  
Goki Suda ◽  
Megumi Kimura ◽  
Osamu Maehara ◽  
Yoshimasa Tokuchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Clinical Data ◽  
Characteristic Curve ◽  
Laboratory Data ◽  
Complete Response ◽  
Serum Samples ◽  
Functional Reserve ◽  
Baseline Serum ◽  
Liver Functional Reserve

A deteriorated liver functional reserve during systemic therapy for unresectable hepatocellular carcinoma (HCC) causes poor patient outcomes. We aimed to identify predictive factors associated with the deterioration of Child-Pugh score at 8 weeks after lenvatinib initiation. Patients with adequate clinical data and baseline preserved serum samples available were included. Baseline fibroblast growth factor (FGF)19 and 21, angiopoietin (ANG)2, and vascular endothelial growth factor (VEGF) levels were evaluated. Thirty-seven patients were included, and 6, 15, 14, and 2 experienced complete response, partial response, stable disease, and progressive disease, respectively. Twenty-four (65%) and 13 (35%) patients showed a maintained/improved and deteriorated Child-Pugh-score, respectively. While baseline clinical data, treatment response, and laboratory data were similar between these two patient groups, baseline ANG2 and VEGF levels were significantly higher (P = 0.0017) and lower (P = 0.0231), respectively, in patients with deteriorated Child-Pugh score than in those without. Based on receiver operating characteristic curve analysis, cut-off values for ANG2 and VEGF were found to be 3,108 pg/mL and 514.9 pg/mL, respectively. Among patients with low VEGF and high ANG2, 89% (8/9) exhibited a deteriorated Child-Pugh score, whereas none of the patients (0/9) with high VEGF and low ANG2 did. The deterioration of the Child-Pugh score in patients with unresectable HCC who are treated with lenvatinib may be predictable based on combined baseline serum ANG2 and VEGF levels.

Risk stratification using a novel liver functional reserve score of combination prothrombin time–international normalized ratio to albumin ratio and albumin in patients with hepatocellular carcinoma

Surgery ◽  
2018 ◽  
Vol 164 (3) ◽  
pp. 404-410 ◽  
Author(s):  
Koichiro Haruki ◽  
Hiroaki Shiba ◽  
Nobuhiro Saito ◽  
Takashi Horiuchi ◽  
Yoshihiro Shirai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Stratification ◽  
Prothrombin Time ◽  
International Normalized Ratio ◽  
Functional Reserve ◽  
Albumin Ratio ◽  
Liver Functional Reserve

scholarly journals REVIEW OF THE EVALUATION OF THE LIVER FUNCTIONAL RESERVE BASED ON THE INDOCYANINE GREEN DYE TEST IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

2000 ◽  
Vol 61 (2) ◽  
pp. 307-312
Author(s):  
Hisao WAKABAYASHI ◽  
Haruhiro YONEMOTO ◽  
Ken ISHIMURA ◽  
Yukihiko KARASAWA ◽  
Seiji MORI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Functional Reserve ◽  
Indocyanine Green Dye ◽  
Liver Functional Reserve

scholarly journals The importance of liver functional reserve in the non-surgical treatment of Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Delia D’Avola ◽  
Alessandro Granito ◽  
Manuel de la Torre-Aláez ◽  
Fabio Piscaglia
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Treatment ◽  
Functional Reserve ◽  
Liver Functional Reserve ◽  
Non Surgical Treatment
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