Perioperative real-time monitoring of indocyanine green clearance by pulse spectrophotometry predicts remnant liver functional reserve in resection of hepatocellular carcinoma

2006 ◽  
Vol 93 (3) ◽  
pp. 339-346 ◽  
Author(s):  
S. Ohwada ◽  
S. Kawate ◽  
K. Hamada ◽  
T. Yamada ◽  
Y. Sunose ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Real Time ◽  
Remnant Liver ◽  
Real Time Monitoring ◽  
Functional Reserve ◽  
Indocyanine Green Clearance ◽  
Liver Functional Reserve

scholarly journals REVIEW OF THE EVALUATION OF THE LIVER FUNCTIONAL RESERVE BASED ON THE INDOCYANINE GREEN DYE TEST IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

2000 ◽  
Vol 61 (2) ◽  
pp. 307-312
Author(s):  
Hisao WAKABAYASHI ◽  
Haruhiro YONEMOTO ◽  
Ken ISHIMURA ◽  
Yukihiko KARASAWA ◽  
Seiji MORI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Functional Reserve ◽  
Indocyanine Green Dye ◽  
Liver Functional Reserve

scholarly journals Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 599
Author(s):  
Ekaterina Savchenko ◽  
Ilya Kolokolnikov ◽  
Elena Velichko ◽  
Victor Osovskikh ◽  
Lyubov Kiseleva ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Treatment Algorithm ◽  
Invasive Technique ◽  
Positive Outcomes ◽  
Test Results ◽  
Reserve Estimation ◽  
Functional Reserve ◽  
Scientific Contribution ◽  
Functional Reserves ◽  
Liver Functional Reserve

This work is aimed at creating a modified invasive technique for assessing the liver’s functional reserves. A study of the degree of hepatodepression is carried out by measuring the plasma elimination of indocyanine green using the method of optical densitometry. This paper presents test results for an aqueous solution and an albumin solution, as well as the results of measurements of plasma elimination of indocyanine green for patients with liver disease. Perfecting the proposed method will make an important scientific contribution to modern diagnostic medicine. Diagnosing the stages in the progression of the disease and its developing complications can make it possible to rapidly correct the patient’s treatment algorithm, achieving positive outcomes in medical practice.

Real-Time Monitoring of Hepatocellular Carcinoma Radiofrequency Ablation by Quantitative Temperature MRI

2006 ◽  
Vol 26 (4) ◽  
pp. 391-397 ◽  
Author(s):  
Hervé Laumonier ◽  
Jean-Frédéric Blanc ◽  
Bruno Quesson ◽  
Olivier Seror ◽  
Christophe Laurent ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Real Time ◽  
Real Time Monitoring

Real-Time Intraoperative Assessment of Residual Liver Functional Reserve Using Pulse Dye Densitometry

2008 ◽  
Vol 32 (12) ◽  
pp. 2668-2674 ◽  
Author(s):  
Hirofumi Akita ◽  
Yo Sasaki ◽  
Terumasa Yamada ◽  
Kunihito Gotoh ◽  
Hiroaki Ohigashi ◽  
...  
Keyword(s):  
Real Time ◽  
Functional Reserve ◽  
Intraoperative Assessment ◽  
Liver Functional Reserve

scholarly journals External Validation of Six Liver Functional Reserve Models to predict Posthepatectomy Liver Failure after Major Resection for Hepatocellular Carcinoma

2021 ◽  
Vol 12 (17) ◽  
pp. 5260-5267
Author(s):  
Guangmeng Guo ◽  
Zhengqing Lei ◽  
Xuewu Tang ◽  
Weihu Ma ◽  
Anfeng Si ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Failure ◽  
External Validation ◽  
Functional Reserve ◽  
Posthepatectomy Liver Failure ◽  
Liver Functional Reserve ◽  
Major Resection

scholarly journals Right hepatectomy with preservation of the entire caudate lobe in patients with metastatic liver tumors: a case of a new hepatectomy technique and treatment strategy for patients with marginal liver function

BMC Surgery ◽  
2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Hiroyuki Kato ◽  
Yukio Asano ◽  
Masahiro Ito ◽  
Satoshi Arakawa ◽  
Norihiko Kawabe ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Indocyanine Green ◽  
Liver Volume ◽  
Caudate Lobe ◽  
Remnant Liver ◽  
Right Hepatectomy ◽  
Indocyanine Green Clearance ◽  
The Right ◽  
Metastatic Liver

Abstract Background Performing major hepatectomy for patients with marginal hepatic function is challenging. In some cases, the procedure is contraindicated owing to the threat of postoperative liver failure. In this case report, we present the first case of marginal liver function (indocyanine green clearance retention rate at 15 min [ICGR15]: 28%) successfully treated with right hepatectomy, resulting in total caudate lobe preservation. Case presentation A 71-year-old man was diagnosed with sigmoid colon cancer with three liver metastases (S5, S7, and S8). All of metastatic lesions shrunk after chemotherapy, but his ICGR15 and indocyanine green clearance rate (ICGK) were 21% and 0.12, respectively. Moreover, the remnant liver volume was only 39%. Therefore, portal venous embolism (PVE) of the right portal vein was suggested. Portography showed divergence of the considerably preserved right caudate lobe branch (PV1R) from the root of the right portal vein. The liver function was reevaluated 18 days after PVE was suggested. During this time, the ICGR15 (21–28%) and ICGK rate (0.12–0.10) deteriorated. The right caudate lobe was significantly enlarged; thus, a total caudate lobe-preserving hepatectomy (TCPRx) was performed. Patients eligible for TCPRx included those with (1) hepatocellular carcinoma or metastatic liver cancer, (2) no tumor in the caudate lobe, (3) marginal liver function (ICG Krem greater than 0.05 if TCPRx was adapted; otherwise, less than 0.05) and Child–Pugh classification category A, and (4) preserved PV1R and right caudate bile duct branch. The procedure was performed through (A) precise estimation of the remnant liver volume preoperatively, (B) repeated intraoperative cholangiography to confirm the biliary branch of the right caudate lobe (B1R) conservation, and (C) stapler division of posterior and anterior Glisson’s pedicles laterally to avoid injuries to the PV1R and B1R. Conclusions Right hepatectomy with total caudate lobe preservation, following PVE, was a safe and viable surgical technique for patients with marginal liver function.

scholarly journals Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247728
Author(s):  
Taku Shigesawa ◽  
Goki Suda ◽  
Megumi Kimura ◽  
Osamu Maehara ◽  
Yoshimasa Tokuchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Clinical Data ◽  
Characteristic Curve ◽  
Laboratory Data ◽  
Complete Response ◽  
Serum Samples ◽  
Functional Reserve ◽  
Baseline Serum ◽  
Liver Functional Reserve

A deteriorated liver functional reserve during systemic therapy for unresectable hepatocellular carcinoma (HCC) causes poor patient outcomes. We aimed to identify predictive factors associated with the deterioration of Child-Pugh score at 8 weeks after lenvatinib initiation. Patients with adequate clinical data and baseline preserved serum samples available were included. Baseline fibroblast growth factor (FGF)19 and 21, angiopoietin (ANG)2, and vascular endothelial growth factor (VEGF) levels were evaluated. Thirty-seven patients were included, and 6, 15, 14, and 2 experienced complete response, partial response, stable disease, and progressive disease, respectively. Twenty-four (65%) and 13 (35%) patients showed a maintained/improved and deteriorated Child-Pugh-score, respectively. While baseline clinical data, treatment response, and laboratory data were similar between these two patient groups, baseline ANG2 and VEGF levels were significantly higher (P = 0.0017) and lower (P = 0.0231), respectively, in patients with deteriorated Child-Pugh score than in those without. Based on receiver operating characteristic curve analysis, cut-off values for ANG2 and VEGF were found to be 3,108 pg/mL and 514.9 pg/mL, respectively. Among patients with low VEGF and high ANG2, 89% (8/9) exhibited a deteriorated Child-Pugh score, whereas none of the patients (0/9) with high VEGF and low ANG2 did. The deterioration of the Child-Pugh score in patients with unresectable HCC who are treated with lenvatinib may be predictable based on combined baseline serum ANG2 and VEGF levels.

scholarly journals Intraoperative simulation of remnant liver function during anatomic liver resection with indocyanine green clearance (LiMON) measurements

HPB ◽  
2015 ◽  
Vol 17 (6) ◽  
pp. 471-476 ◽  
Author(s):  
Michael N. Thomas ◽  
Ernst Weninger ◽  
Martin Angele ◽  
Florian Bösch ◽  
Sebastian Pratschke ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Function ◽  
Indocyanine Green ◽  
Remnant Liver ◽  
Indocyanine Green Clearance ◽  
Remnant Liver Function
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