scholarly journals Prognostic significance of early recurrence: a conditional survival analysis in patients with resected colorectal liver metastasis

HPB ◽  
2013 ◽  
Vol 15 (10) ◽  
pp. 803-813 ◽  
Author(s):  
Marcus C.B. Tan ◽  
Jean M. Butte ◽  
Mithat Gonen ◽  
Nancy Kemeny ◽  
Yuman Fong ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Prognostic Significance ◽  
Early Recurrence ◽  
Conditional Survival

scholarly journals Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection

2021 ◽  
Vol Volume 13 ◽  
pp. 163-171
Author(s):  
Aleksandar Bogdanovic ◽  
Jovana Despotovic ◽  
Danijel Galun ◽  
Nemanja Bidzic ◽  
Aleksandra Nikolic ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Prognostic Significance ◽  
Early Recurrence

Predictors for Early Recurrence After Hepatectomy for Initially Unresectable Colorectal Liver Metastasis

2013 ◽  
Vol 17 (5) ◽  
pp. 939-948 ◽  
Author(s):  
Shinichiro Takahashi ◽  
Masaru Konishi ◽  
Takahiro Kinoshita ◽  
Naoto Gotohda ◽  
Yuichiro Kato ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Early Recurrence

scholarly journals Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis

2020 ◽  
Vol 217 (11) ◽  
Author(s):  
Matteo Donadon ◽  
Guido Torzilli ◽  
Nina Cortese ◽  
Cristiana Soldani ◽  
Luca Di Tommaso ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Single Cell ◽  
Colorectal Liver Metastasis ◽  
Single Cell Analysis ◽  
Cholesterol Metabolism ◽  
Survival Rates ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Mononuclear Phagocytes

It has long been known that in vitro polarized macrophages differ in morphology. Stemming from a conventional immunohistology observation, we set out to test the hypothesis that morphology of tumor-associated macrophages (TAMs) in colorectal liver metastasis (CLM) represents a correlate of functional diversity with prognostic significance. Density and morphological metrics of TAMs were measured and correlated with clinicopathological variables. While density of TAMs did not correlate with survival of CLM patients, the cell area identified small (S-TAM) and large (L-TAM) macrophages that were associated with 5-yr disease-free survival rates of 27.8% and 0.2%, respectively (P < 0.0001). RNA sequencing of morphologically distinct macrophages identified LXR/RXR as the most enriched pathway in large macrophages, with up-regulation of genes involved in cholesterol metabolism, scavenger receptors, MERTK, and complement. In single-cell analysis of mononuclear phagocytes from CLM tissues, S-TAM and L-TAM signatures were differentially enriched in individual clusters. These results suggest that morphometric characterization can serve as a simple readout of TAM diversity with strong prognostic significance.

Long-Term Results and Prognostic Significance of Non-ANATOMIC Liver Resection for Colorectal Liver Metastasis: Single Center Experience

2019 ◽  
Vol 82 (2) ◽  
pp. 197-204
Author(s):  
Osman Civil ◽  
Nuri Okkabaz ◽  
Tevfik Tolga Sahin ◽  
Cagri Tiryaki ◽  
Murat Burc Yazicioglu ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Prognostic Significance ◽  
Long Term Results ◽  
Single Center ◽  
Single Center Experience

Phase II multicenter study of adjuvant S-1 for colorectal liver metastasis: survival analysis of N-SOG 01 trial

2015 ◽  
Vol 75 (6) ◽  
pp. 1281-1288 ◽  
Author(s):  
Takehiro Kato ◽  
◽  
Keisuke Uehara ◽  
Atsuyuki Maeda ◽  
Eiji Sakamoto ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Liver Metastasis ◽  
Phase Ii ◽  
Colorectal Liver Metastasis ◽  
Multicenter Study

Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Surgical Intervention ◽  
Liver Volume ◽  
Sigmoid Colon Cancer ◽  
Remnant Liver ◽  
Future Remnant Liver ◽  
The Right ◽  
Synchronous Colorectal Liver Metastasis ◽  
Right Hepatic Vein

A 72-year-old woman with a sigmoid colon cancer anda synchronous colorectal liver metastasis (CRLM), whichinvolved the right hepatic vein (RHV) and the inferiorvena cava (IVC), was referred to our hospital. Themetastatic lesion was diagnosed as initially unresectablebecause of its invasion into the confluence of theRHV and IVC. After she had undergone laparoscopicsigmoidectomy for the original tumor, she consequentlyhad 3 courses of modified 5-fluorouracil, leucovorin,and oxaliplatin (mFOLFOX6) plus cetuximab. Computedtomography revealed a partial response, and theconfluence of the RHV and IVC got free from cancerinvasion. After 3 additional courses of mFOLFOX6 pluscetuximab, preoperative percutaneous transhepaticportal vein embolization (PTPE) was performed tosecure the future remnant liver volume. Finally, a righthemihepatectomy was performed. The postoperativecourse was uneventful. The patient was dischargedfrom the hospital on postoperative day 13. She hadneither local recurrence nor distant metastasis 18 moafter the last surgical intervention. This multidisciplinarystrategy, consisting of conversion chemotherapy usingFOLFOX plus cetuximab and PTPE, could contributein facilitating curative hepatic resection for initiallyunresectable CRLM.Key words: Initially unresectable; Colorectal liver metastasis;Conversion chemotherapy; Cetuximab; Percutaneoustranshepatic portal vein embolization

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