Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle thataffects many teenagers and young people. There is an obvious need for topical treatments with goodtolerability and efficacy for the management of acne lesions.
Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution(0.005%) in the treatment of mild to moderate acne lesions.
Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochloriteto placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. Thenumbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation.
Results: The total number of papules and pustules decreased after topical application of sodiumhypochlorite 0.005% for 1 month.
Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mildto moderate acne, and its clinical efficacy was evaluated between the male and female groups andbetween the hormonal and non-hormonal ones.
Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with thecode number IRCT20200701047976N1.
Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double‐blind trial
