Lymph Node Involvement in Epithelial Ovarian Cancer

2009 ◽  
Vol 19 (8) ◽  
pp. 1307-1313 ◽  
Author(s):  
Marion Fournier ◽  
Eberhard Stoeckle ◽  
Frédéric Guyon ◽  
Véronique Brouste ◽  
Laurence Thomas ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Epithelial Ovarian Cancer ◽  
Lymph Node Involvement ◽  
Node Involvement

scholarly journals Role of pelvic and para-aortic lymphadenectomy in epithelial ovarian cancers

2019 ◽  
Vol 9 (1) ◽  
pp. 328
Author(s):  
Pankush Gupta ◽  
Sunesh Kumar ◽  
Seema Singhal ◽  
Jyoti Meena ◽  
Sandeep Mathur ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Epithelial Ovarian Cancer ◽  
Operating Time ◽  
Lymph Node Involvement ◽  
Peritoneal Cytology ◽  
Nodal Involvement ◽  
Surgical Morbidity ◽  
Ovarian Cancers ◽  
Node Involvement

Background: Lymphadenectomy in epithelial ovarian cancers has remained a controversial subject. Lack of robust evidence on survival benefits and surgical morbidity associated questions its role in the era of adjuvant chemotherapy. The present study assessed pelvic and para-aortic lymph node removal in epithelial ovarian cancer in Indian women and tried to find clinicopathological correlation of nodal involvement and postoperative implications of lymphadenectomy.Methods: Thirty patients with diagnosis of epithelial ovarian cancer posted for primary debulking surgery were recruited and underwent staging laparotomy along with pelvic and para-aortic lymphadenectomy. Nodal involvement was confirmed on histopathology and various parameters which could predict nodal metastasis were assessed. Patients were followed up for 12 months post-surgery.Results: Nodal yield was ten for pelvic and four for paraaortic nodes. Pelvic node involvement was seen in 26.6% (8/30) of the patients and para-aortic in 15% (3/20) of the patients. Serous histology, higher grade, stage 3 and above, positive peritoneal cytology, omental involvement showed a higher lymph node involvement though not statistically significant. Para-aortic lymphadenectomy was associated with increased operating time, blood loss and longer hospital stay.Conclusions: Lymphadenectomy increases morbidity and decision should be based on predictors of nodal involvement.

Lymph node involvement in epithelial ovarian cancer: analysis of 276 pelvic and paraaortic lymphadenectomies and surgical implications

2003 ◽  
Vol 197 (2) ◽  
pp. 198-205 ◽  
Author(s):  
Philippe Morice ◽  
Franklin Joulie ◽  
Sophie Camatte ◽  
David Atallah ◽  
Roman Rouzier ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Epithelial Ovarian Cancer ◽  
Lymph Node Involvement ◽  
Node Involvement

LYMPH NODE INVOLVEMENT IN EPITHELIAL OVARIAN CANCER: ANALYSIS OF 276 PELVIC AND PARA-AORTIC LYMPHADENECTOMIES

2003 ◽  
Vol 13 (Suppl 1) ◽  
pp. 37.2-37
Author(s):  
P. Morice ◽  
F. Joulie ◽  
D. Atallah ◽  
S. Camatte ◽  
R. Rouzier ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Epithelial Ovarian Cancer ◽  
Lymph Node Involvement ◽  
Node Involvement

scholarly journals Relationship between Pelvic Lymph Node Involvement and Other Disease Sites in Patients with Ovarian Cancer

1997 ◽  
Vol 65 (1) ◽  
pp. 164-168 ◽  
Author(s):  
Kunihiro Sakai ◽  
Toshiharu Kamura ◽  
Toshio Hirakawa ◽  
Toshiaki Saito ◽  
Tsunehisa Kaku ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Pelvic Lymph Node ◽  
Node Involvement ◽  
Pelvic Lymph Node Involvement

Pattern and clinical predictors of lymph node metastases in epithelial ovarian cancer

2007 ◽  
Vol 17 (6) ◽  
pp. 1238-1244 ◽  
Author(s):  
P. Harter ◽  
K. Gnauert ◽  
R. Hils ◽  
T. G. Lehmann ◽  
A. Fisseler-Eckhoff ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Epithelial Ovarian Cancer ◽  
Lymph Node Metastases ◽  
Frozen Section ◽  
Vena Cava ◽  
Lymph Node Involvement ◽  
Clinical Predictors ◽  
Node Metastases

Para-aortic lymphadenectomy is part of staging in early epithelial ovarian cancer (EOC) and could be part of therapy in advanced EOC. However, only a minority of patients receive therapy according to guidelines or have attendance to a specialized unit. We analyzed pattern of lymphatic spread of EOC and evaluated if clinical factors and intraoperative findings reliably could predict lymph node involvement, in order to evaluate if patients could be identified in whom lymphadenectomy could be omitted and who should not be referred to a center with capacity of performing extensive gynecological operations. Retrospective analysis was carried out of all patients with EOC who had systematic pelvic and para-aortic lymphadenectomy during primary cytoreductive surgery. One hundred ninety-five patients underwent systematic pelvic and para-aortic lymphadenectomy. Histologic lymph node metastases were found in 53%. The highest frequency was found in the upper left para-aortic region (32% of all patients) and between vena cava inferior and abdominal aorta (36%). Neither intraoperative clinical diagnosis nor frozen section of pelvic nodes could reliably predict para-aortic lymph node metastasis. The pathologic diagnosis of the pelvic nodes, if used as diagnostic tool for para-aortic lymph nodes, showed a sensitivity of only 50% in ovarian cancer confined to the pelvis and 73% in more advanced disease. We could not detect any intraoperative tool that could reliably predict pathologic status of para-aortic lymph nodes. Systematic pelvic and para-aortic lymphadenectomy remains part of staging in EOC. Patients with EOC should be offered the opportunity to receive state-of-the-art treatment including surgery

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