The effect of platinum-based combination chemotherapy on the lymph nodes in advanced-stage epithelial ovarian cancer: does it decrease the incidence of lymph node involvement?

2002 ◽  
Vol 22 (6) ◽  
pp. 666-668 ◽  
Author(s):  
T. Simsek ◽  
M. Simsek ◽  
E. Pesterelli ◽  
S. Karaveli ◽  
B. Trak
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Epithelial Ovarian Cancer ◽  
Combination Chemotherapy ◽  
Lymph Node Involvement ◽  
Advanced Stage ◽  
Node Involvement

Pattern and clinical predictors of lymph node metastases in epithelial ovarian cancer

2007 ◽  
Vol 17 (6) ◽  
pp. 1238-1244 ◽  
Author(s):  
P. Harter ◽  
K. Gnauert ◽  
R. Hils ◽  
T. G. Lehmann ◽  
A. Fisseler-Eckhoff ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Epithelial Ovarian Cancer ◽  
Lymph Node Metastases ◽  
Frozen Section ◽  
Vena Cava ◽  
Lymph Node Involvement ◽  
Clinical Predictors ◽  
Node Metastases

Para-aortic lymphadenectomy is part of staging in early epithelial ovarian cancer (EOC) and could be part of therapy in advanced EOC. However, only a minority of patients receive therapy according to guidelines or have attendance to a specialized unit. We analyzed pattern of lymphatic spread of EOC and evaluated if clinical factors and intraoperative findings reliably could predict lymph node involvement, in order to evaluate if patients could be identified in whom lymphadenectomy could be omitted and who should not be referred to a center with capacity of performing extensive gynecological operations. Retrospective analysis was carried out of all patients with EOC who had systematic pelvic and para-aortic lymphadenectomy during primary cytoreductive surgery. One hundred ninety-five patients underwent systematic pelvic and para-aortic lymphadenectomy. Histologic lymph node metastases were found in 53%. The highest frequency was found in the upper left para-aortic region (32% of all patients) and between vena cava inferior and abdominal aorta (36%). Neither intraoperative clinical diagnosis nor frozen section of pelvic nodes could reliably predict para-aortic lymph node metastasis. The pathologic diagnosis of the pelvic nodes, if used as diagnostic tool for para-aortic lymph nodes, showed a sensitivity of only 50% in ovarian cancer confined to the pelvis and 73% in more advanced disease. We could not detect any intraoperative tool that could reliably predict pathologic status of para-aortic lymph nodes. Systematic pelvic and para-aortic lymphadenectomy remains part of staging in EOC. Patients with EOC should be offered the opportunity to receive state-of-the-art treatment including surgery

Lymph Node Involvement in Epithelial Ovarian Cancer

2009 ◽  
Vol 19 (8) ◽  
pp. 1307-1313 ◽  
Author(s):  
Marion Fournier ◽  
Eberhard Stoeckle ◽  
Frédéric Guyon ◽  
Véronique Brouste ◽  
Laurence Thomas ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Epithelial Ovarian Cancer ◽  
Lymph Node Involvement ◽  
Node Involvement

scholarly journals Role of pelvic and para-aortic lymphadenectomy in epithelial ovarian cancers

2019 ◽  
Vol 9 (1) ◽  
pp. 328
Author(s):  
Pankush Gupta ◽  
Sunesh Kumar ◽  
Seema Singhal ◽  
Jyoti Meena ◽  
Sandeep Mathur ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Epithelial Ovarian Cancer ◽  
Operating Time ◽  
Lymph Node Involvement ◽  
Peritoneal Cytology ◽  
Nodal Involvement ◽  
Surgical Morbidity ◽  
Ovarian Cancers ◽  
Node Involvement

Background: Lymphadenectomy in epithelial ovarian cancers has remained a controversial subject. Lack of robust evidence on survival benefits and surgical morbidity associated questions its role in the era of adjuvant chemotherapy. The present study assessed pelvic and para-aortic lymph node removal in epithelial ovarian cancer in Indian women and tried to find clinicopathological correlation of nodal involvement and postoperative implications of lymphadenectomy.Methods: Thirty patients with diagnosis of epithelial ovarian cancer posted for primary debulking surgery were recruited and underwent staging laparotomy along with pelvic and para-aortic lymphadenectomy. Nodal involvement was confirmed on histopathology and various parameters which could predict nodal metastasis were assessed. Patients were followed up for 12 months post-surgery.Results: Nodal yield was ten for pelvic and four for paraaortic nodes. Pelvic node involvement was seen in 26.6% (8/30) of the patients and para-aortic in 15% (3/20) of the patients. Serous histology, higher grade, stage 3 and above, positive peritoneal cytology, omental involvement showed a higher lymph node involvement though not statistically significant. Para-aortic lymphadenectomy was associated with increased operating time, blood loss and longer hospital stay.Conclusions: Lymphadenectomy increases morbidity and decision should be based on predictors of nodal involvement.

scholarly journals Extracapsular Lymph Node Involvement in Ovarian Carcinoma

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 924 ◽  
Author(s):  
Sabine Heublein ◽  
Heiko Schulz ◽  
Frederik Marmé ◽  
Martin Angele ◽  
Bastian Czogalla ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
Tumor Tissue ◽  
Lymph Node Involvement ◽  
Node Positive ◽  
Node Involvement ◽  
Lymph Node Positive

Ovarian cancer (OC) spread to retro-peritoneal lymph nodes is detected in about one out of two patients at primary diagnosis. Whether the histologic pattern of lymph node involvement i.e., intra-(ICG) or extracapsular (ECG) cancer growth may affect patients’ prognosis remains unknown. The aim of the current study was to analyze the prevalence of ECG and ICG in lymph node positive ovarian cancer. We further investigated whether ECG may be related to patients’ prognosis and whether biomarkers expressed in the primary tumor may predict the pattern of lymph node involvement. Lymph node samples stemming from 143 OC patients were examined for presence of ECG. Capsular extravasation was tested for statistical association with clinico-pathological variables. We further tested 27 biomarkers that had been determined in primary tumor tissue for their potential to predict ECG in metastatic lymph nodes. ECG was detected in 35 (24.5%) of 143 lymph node positive patients. High grade (p = 0.043), histologic subtype (p = 0.006) and high lymph node ratio (LNR) (p < 0.001) were positively correlated with presence of ECG. Both ECG (p = 0.024) and high LNR (p = 0.008) were predictive for shortened overall survival. A four-protein signature determined from the primary tumor tissue was associated with presence of concomitant extracapsular spread in lymph nodes of the respective patient. This work found extracapsular spread of lymph node metastasis to be a common feature of lymph node positive ovarian cancer. Since ECG was positively associated with grade, LNR and shortened overall survival, we hypothesize that the presence of ECG may be interpreted as an indicator of tumor aggressiveness.

Sign in / Sign up

Export Citation Format

Share Document