Is overactive bladder a brain disease? The pathophysiological role of cerebral white matter in the elderly

Translational research in preterm brain injury depends upon the delineation of the human neuropathology in order that animal models faithfully reiterate it, thereby ensuring direct relevance to the human condition. The major substrate of human preterm brain injury is the encephalopathy of prematurity that is characterized by gray and white matter lesions reflecting combined acquired insults, altered developmental trajectories, and reparative phenomena. Here we highlight the key features of human preterm brain development and the encephalopathy of prematurity that are critical for modeling in animals. The complete mimicry of the complex human neuropathology is difficult in animal models. Many models focus upon mechanisms related to a specific feature, for example, loss of premyelinating oligodendrocytes in the cerebral white matter. Nevertheless, animal models that simultaneously address oligodendrocyte, neuronal, and axonal injury carry the potential to decipher shared mechanisms and synergistic treatments to ameliorate the global consequences of the encephalopathy of prematurity.

Download Full-text

The association between impaired perception of verticality and cerebral white matter lesions in the elderly patients with orthostatic hypotension

Journal of Vestibular Research ◽

10.3233/ves-130479 ◽

2013 ◽

Vol 23 (2) ◽

pp. 85-93 ◽

Cited By ~ 8

Author(s):

Mitsuhiro Aoki ◽

Kunihiko Tanaka ◽

Takanori Wakaoka ◽

Bunya Kuze ◽

Hisamitsu Hayashi ◽

...

Keyword(s):

White Matter ◽

Elderly Patients ◽

Orthostatic Hypotension ◽

White Matter Lesions ◽

The Elderly ◽

Cerebral White Matter ◽

Cerebral White Matter Lesions ◽

Perception Of Verticality

Download Full-text

Cerebral white matter lesions and perceived cognitive dysfunction: the role of pregnancy

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2014.02.031 ◽

2014 ◽

Vol 211 (3) ◽

pp. 257.e1-257.e5 ◽

Cited By ~ 8

Author(s):

Ineke R. Postma ◽

Jan Cees de Groot ◽

Annet M. Aukes ◽

Jan G. Aarnoudse ◽

Gerda G. Zeeman

Keyword(s):

White Matter ◽

Cognitive Dysfunction ◽

White Matter Lesions ◽

Cerebral White Matter ◽

Cerebral White Matter Lesions

Download Full-text

Associations between Ambulatory Blood Pressure Parameters and Cerebral White Matter Lesions

International Journal of Hypertension ◽

10.4061/2011/478710 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Cristina Sierra

Keyword(s):

Blood Pressure ◽

White Matter ◽

Ambulatory Blood Pressure ◽

Blood Pressure Monitoring ◽

White Matter Lesions ◽

The Elderly ◽

Organ Damage ◽

Common Finding ◽

Cerebral White Matter ◽

Cerebral White Matter Lesions

Silent cerebral white matter lesions (WMLs) are a common finding on magnetic resonance imaging of the brain in the elderly. However, in patients with hypertension, WMLs tend to occur earlier in life and appear to be more severe. There is a body of evidence that supports the idea that WMLs in asymptomatic hypertensive patients should be considered a silent early marker of brain damage. It is known that ambulatory blood pressure monitoring (ABPM) correlates more closely with hypertension-related organ damage than office blood pressure. This paper focuses on the associations between blood pressure parameters obtained by 24-hour ABMP and cerebral WMLs.

Download Full-text