scholarly journals Intranasal delivery of FSD-C10, a novel Rho kinase inhibitor, exhibits therapeutic potential in experimental autoimmune encephalomyelitis

Immunology ◽  
2014 ◽  
Vol 143 (2) ◽  
pp. 219-229 ◽  
Author(s):  
Yan-Hua Li ◽  
Jie-Zhong Yu ◽  
Chun-Yun Liu ◽  
Hui Zhang ◽  
Hai-Fei Zhang ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Kinase Inhibitor ◽  
Therapeutic Potential ◽  
Rho Kinase ◽  
Intranasal Delivery ◽  
Autoimmune Encephalomyelitis ◽  
Rho Kinase Inhibitor ◽  
Experimental Autoimmune

The Therapeutic Potential of Rho Kinase Inhibitor Fasudil Derivative FaD-1 in Experimental Autoimmune Encephalomyelitis

2014 ◽  
Vol 55 (3) ◽  
pp. 725-732 ◽  
Author(s):  
Yong-Fei Zhao ◽  
Xiang Zhang ◽  
Zhi-Bin Ding ◽  
Xing-Wang Yang ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Kinase Inhibitor ◽  
Therapeutic Potential ◽  
Rho Kinase ◽  
Autoimmune Encephalomyelitis ◽  
Rho Kinase Inhibitor ◽  
Experimental Autoimmune

Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Jie-Zhong Yu ◽  
Jing Ding ◽  
Cun-Gen Ma ◽  
Chang-Hai Sun ◽  
Yi-Fu Sun ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Kinase Inhibitor ◽  
Therapeutic Potential ◽  
Rho Kinase ◽  
Autoimmune Encephalomyelitis ◽  
Rho Kinase Inhibitor ◽  
Experimental Autoimmune

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis

2006 ◽  
Vol 180 (1-2) ◽  
pp. 126-134 ◽  
Author(s):  
Xiaojia Sun ◽  
Motozumi Minohara ◽  
Hitoshi Kikuchi ◽  
Takaaki Ishizu ◽  
Masahito Tanaka ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Autoimmune Encephalomyelitis ◽  
Rho Kinase Inhibitor ◽  
Experimental Autoimmune

Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms

2018 ◽  
Vol 34 (2) ◽  
pp. 377-384 ◽  
Author(s):  
Yuqing Yan ◽  
Jiezhong Yu ◽  
Ye Gao ◽  
Gajendra Kumar ◽  
Minfang Guo ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Autoimmune Encephalomyelitis ◽  
Rho Kinase Inhibitor ◽  
Experimental Autoimmune

Y-39983, a Selective Rho-Kinase Inhibitor, Attenuates Experimental Autoimmune Encephalomyelitis via Inhibition of Demyelination

2013 ◽  
Vol 20 (6) ◽  
pp. 334-340 ◽  
Author(s):  
Cong Gao ◽  
Li Huang ◽  
Youming Long ◽  
Jianzheng Zheng ◽  
Jie Yang ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Autoimmune Encephalomyelitis ◽  
Rho Kinase Inhibitor ◽  
Experimental Autoimmune

Fasudil-modified macrophage exhibits therapeutic potential in experimental autoimmune encephalomyelitis

2017 ◽  
Vol 381 ◽  
pp. 913
Author(s):  
C.Y. Liu ◽  
S.D. Guo ◽  
Z. Chai ◽  
Y.H. Li ◽  
J.Z. Yu ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Therapeutic Potential ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Thais Fernanda de Campos Fraga-Silva ◽  
Luiza Ayumi Nishiyama Mimura ◽  
Larissa Ragozo Cardoso de Oliveira ◽  
Juliana Helena dos Santos Toledo ◽  
Patrícia Aparecida Borim ◽  
...  
Keyword(s):  
Immune Response ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Lymph Nodes ◽  
Therapeutic Potential ◽  
Clinical Signs ◽  
Mesenteric Lymph Nodes ◽  
Autoimmune Encephalomyelitis ◽  
Complementary Medicines ◽  
Mesenteric Lymph ◽  
Experimental Autoimmune

AbstractMultiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines have been adopted and evidence indicates that yeast supplements can improve symptoms mainly by modulating the immune response. In this investigation, we evaluated the therapeutic potential of Saccharomyces cerevisiae and its selenized derivative (Selemax) in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice submitted to EAE induction were orally supplemented with these yeasts by gavage from day 0 to day 14 after EAE induction. Both supplements determined significant reduction in clinical signs concomitantly with diminished Th1 immune response in CNS, increased proportion of Foxp3+ lymphocytes in inguinal and mesenteric lymph nodes and increased microbiota diversity. However, Selemax was more effective clinically and immunologically; it reduced disease prevalence more sharply, increased the proportion of CD103+ dendritic cells expressing high levels of PD-L1 in mesenteric lymph nodes and reduced the intestinal inflammatory process more strongly than S. cerevisiae. These results suggest a clear gut-brain axis modulation by selenized S. cerevisiae and suggest their inclusion in clinical trials.

scholarly journals Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis

2019 ◽  
Vol 25 (6) ◽  
pp. 783-795
Author(s):  
Shang-De Guo ◽  
Chun-Yun Liu ◽  
Jing-Wen Yu ◽  
Zhi Chai ◽  
Qing Wang ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Immune Cells ◽  
Therapeutic Potential ◽  
Nasal Delivery ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune
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