scholarly journals MicroRNA expression profiling of human blood monocyte subsets highlights functional differences

Immunology ◽  
2015 ◽  
Vol 145 (3) ◽  
pp. 404-416 ◽  
Author(s):  
Truong-Minh Dang ◽  
Wing-Cheong Wong ◽  
Siew-Min Ong ◽  
Peng Li ◽  
Josephine Lum ◽  
...  



2017 ◽  
Vol 37 (8) ◽  
pp. 1548-1558 ◽  
Author(s):  
Graham D. Thomas ◽  
Anouk A.J. Hamers ◽  
Catherine Nakao ◽  
Paola Marcovecchio ◽  
Angela M. Taylor ◽  
...  


PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36435 ◽  
Author(s):  
Kok Loon Wong ◽  
Weiqiang Chen ◽  
Thavamalar Balakrishnan ◽  
Ying Xiu Toh ◽  
Katja Fink ◽  
...  


1985 ◽  
Vol 37 (5) ◽  
pp. 519-530 ◽  
Author(s):  
Y. Akiyama ◽  
G.W. Stevenson ◽  
E. Schlick ◽  
K. Matsushima ◽  
P.J. Miller ◽  
...  


2001 ◽  
Vol 13 (12) ◽  
pp. 1571-1581 ◽  
Author(s):  
Carmen Sánchez-Torres ◽  
Gina S. García-Romo ◽  
Miguel A. Cornejo-Cortés ◽  
Amaranta Rivas-Carvalho ◽  
Guzmán Sánchez-Schmitz






Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 298-301
Author(s):  
JA Elias ◽  
P Chien ◽  
KM Gustilo ◽  
AD Schreiber

Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.



Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 298-301 ◽  
Author(s):  
JA Elias ◽  
P Chien ◽  
KM Gustilo ◽  
AD Schreiber

Abstract Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.



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