Circulatory response to prenalterol in normal subjects and in patients with primary congestive cardiomyopathy

2009 ◽  
Vol 211 (S659) ◽  
pp. 233-250
Author(s):  
M. D. Guazzi ◽  
Lü Guo Qing ◽  
M. T. Olivari ◽  
C. Fiorentini ◽  
A. Loaldi ◽  
...  
1976 ◽  
Vol 40 (3) ◽  
pp. 434-440 ◽  
Author(s):  
P. I. Korner ◽  
A. M. Tonkin ◽  
J. B. Uther

In 17 normal subjects we studied the changes evoked by five levels of expiratory pressure (EP) ranging from 2.5 to 30 mmHg in a number of circulatory variables during the last 10 s of a 30-s Valsalva maneuver. Variables studied included mean arterial (MAP) and pulse (PP) pressures; right atrial (RAP) and peripheral vein (PVP) pressures; cardiac output (CO); total peripheral resistance (TPR) and heart rate (HR). EP-circulatory response curves were obtained in each subject a) before autonomic block; b) after cardiac effector block (atropine + propranolol); c) after “total” autonomic block (atropine + propranolol; guanethidine + phentolamine). Mechanical effects were determined from results during “total” autonomic block. They included EP-related rises in RAP and PVP each to about 0.7 mmHg/mmHg applied EP, and falls in CO, MAP, and PP to levels of approximately 50%, 70%, and 80% of resting respectively at EP 30 mmHg, but no changes in TPR and HR. Reflex effects included EP-related rises in HR and in TPR and in MAP, to levels of 160%, 160%, and 115% of resting respectively at EP 30 mmHg. The afferent input profile is probably complex, and the role of the different receptor groups may vary at the different levels of EP.


Circulation ◽  
1974 ◽  
Vol 49 (6) ◽  
pp. 1153-1159 ◽  
Author(s):  
BETTY C. CORYA ◽  
HARVEY FEIGENBAUM ◽  
SUSAN RASMUSSEN ◽  
MARY J. BLACK

Heart ◽  
1976 ◽  
Vol 38 (7) ◽  
pp. 695-700 ◽  
Author(s):  
R M Rossen ◽  
E L Alderman ◽  
D C Harrison

Circulation ◽  
1967 ◽  
Vol 35 (6) ◽  
pp. 1049-1062 ◽  
Author(s):  
STEPHEN E. EPSTEIN ◽  
G. DAVID BEISER ◽  
MORRIS STAMPFER ◽  
BRIAN F. ROBINSON ◽  
EUGENE BRAUNWALD

1985 ◽  
Vol 16 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Lee Ann Laraway

The purpose of this study was to determine whether there is a statistically significant difference between the auditory selective attention abilities of normal and cerebral-palsied individuals. Twenty-three cerebral-palsied and 23 normal subjects between the ages of 5 and 21 were asked to repeat a series of 30 items consisting of from 2 to 4 digits in the presence of intermittent white noise. Results of the study indicate that cerebral-palsied individuals perform significantly poorer than normal individuals when the stimulus is accompanied by noise. Noise was not a significant factor in the performance of the normal subjects regardless of age.


1965 ◽  
Vol 8 (3) ◽  
pp. 223-234 ◽  
Author(s):  
William Melnick

Five subjects with normal middle ear mechanisms, and otosclerotic patients, before and after stapedectomy, matched the loudness of their voices to the loudness of a 125-cps-sawtooth noise. The results showed loudness matching functions with gradual slopes, less than 1.00, for the normal subjects and the patients prior to stapedectomy. Post-surgically, the loudness function for the patients increased in steepness to considerably more than 1.00. These results are explained, most logically, in terms of increased sensitivity of the altered middle ear to sound energy generated by the listener’s own voice.


1964 ◽  
Vol 7 (4) ◽  
pp. 369-371
Author(s):  
Samuel Fillenbaum

Binaurally asynchronous delayed auditory feedback (DAF) was compared with synchronous DAF in 80 normal subjects. Asynchronous DAF (0.10 sec difference) did not yield results different from those obtained under synchronous DAF with a 0.20 sec delay interval, an interval characteristically resulting in maximum disruptions in speech.


1988 ◽  
Vol 53 (4) ◽  
pp. 459-466 ◽  
Author(s):  
Brenda Y. Terrell ◽  
Richard G. Schwartz

The play behavior of 10 language-impaired children was observed. Their performances in play were compared to those of 10 normal-language children matched for chronological age as well as to those of 10 normal-language children matched for mean length of utterance. The children were observed as they played spontaneously with a standard group of toys and as they played with objects that required object transformations for successful play. The chronological age-matched normal subjects showed a trend toward performance of more object transformations in play than either the language-impaired or younger normal-language children. Additionally, although object transformations were observed in both segments, all children performed more object transformations with objects than with toys.


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