Organ Culture of Human Hair Follicles Derived from Different Areas of the Body

1992 ◽  
Vol 19 (6) ◽  
pp. 348-352 ◽  
Author(s):  
Shigeo Kondo ◽  
Yutaka Hozumi ◽  
Noriaki Sato ◽  
Kazuo Aso
Keyword(s):  
Organ Culture ◽  
Human Hair ◽  
Hair Follicles ◽  
The Body

scholarly journals Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mira Choi ◽  
Soon-Jin Choi ◽  
Sunhyae Jang ◽  
Hye-In Choi ◽  
Bo-Mi Kang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Organ Culture ◽  
Human Hair ◽  
Hair Growth ◽  
Shikimic Acid ◽  
Ex Vivo ◽  
Hair Follicles ◽  
Anagen Hair

AbstractShikimic acid (SA) has recently been found to be a major component of plant stem cells. The exact effects of SA on human hair follicles (HFs) is unknown. The purpose of this study was to examine the effects of SA on hair growth. We investigated the effect of SA on an in vivo C57BL/6 mouse model. We examined the expression of mannose receptor (MR), which is a known receptor of SA, in human HFs and the effect of SA on human dermal papilla cells (hDPCs), outer root sheath cells (hORSCs), and on ex vivo human hair organ culture. SA significantly prolonged anagen hair growth in the in vivo mouse model. We confirmed expression of the MR in human HFs, and that SA increased the proliferation of hDPCs and hORSCs. It was found that SA enhanced hair shaft elongation in an ex vivo human hair organ culture. SA treatment of hDPCs led to increased c-myc, hepatocyte growth factor, keratinocyte growth factor and vascular endothelial growth factor levels and upregulation of p38 MAPK and cAMP response element-binding protein levels. Our results show that SA promotes hair growth and may serve as a new therapeutic agent in the treatment of alopecia.

scholarly journals Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life

2018 ◽  
Vol 32 (2) ◽  
pp. 795-806 ◽  
Author(s):  
Benjamin H. Miranda ◽  
Matthew R. Charlesworth ◽  
Desmond J. Tobin ◽  
David T. Sharpe ◽  
Valerie A. Randall
Keyword(s):  
Organ Culture ◽  
Human Hair ◽  
Hair Follicles ◽  
Growth Responses ◽  
Epigenetic Diversity

scholarly journals DEMONSTRATION OF THE HUMAN HAIR FOLLICLE MAGNETORECEPTION OF BIOMAGNETISM RADIATED BY THE CONCAVE PART OF THE HUMAN HAND

2020 ◽  
Vol 8 (5) ◽  
pp. 348-354
Author(s):  
Abraham A. Embi
Keyword(s):  
Optical Microscopy ◽  
Hair Follicle ◽  
Human Hair ◽  
Quantum Interference ◽  
Hair Follicles ◽  
The Body ◽  
Human Hand ◽  
Human Hair Follicle ◽  
Concave Part ◽  
Microscopy Method

Biological material has been documented to produce an external magnetic field that radiates out. There have been several papers documenting the magnetic fields produced by steady currents in the body. The most notable was published in 1980 by Cohen et al. where the human hair follicle was used as sentinel and biophysically evaluated via sophisticated equipment such as a double planar Superconducting Quantum Interference Devices (SQUID). Most recently, in 2019 Cohen’s work was duplicated by Khan,S by also using double-planar gladiometers. Of interest to this manuscript is that since the introduction of anovel optical microscopy method in 2016 by Scherlag BJ et al is that numerous papers have been introduced in the literature now identifying intrinsic biomagnetic properties of the follicle such as penetration through glass barriers. In this manuscript, a concept of biomagnetic fields by the concave part of the human hand transferring energy to hair follicles is introduced, this was accomplished by using a novel optical microscopy method, in other words, the hair follicle is not limited to radiate out biomagnetism; but also, to receive externally radiated biomagnetic fields from a body part. This magneto receptive property is herein introduced.

Organ culture of human hair follicles in serum-free medium

1993 ◽  
Vol 284 (8) ◽  
pp. 466-471 ◽  
Author(s):  
R. Imai ◽  
T. Jindo ◽  
Y. Miura ◽  
K. Mochida ◽  
K. Takamori ◽  
...  
Keyword(s):  
Organ Culture ◽  
Human Hair ◽  
Hair Follicles ◽  
Serum Free Medium ◽  
Free Medium ◽  
Serum Free

scholarly journals Organ culture of human hair follicles

1992 ◽  
Vol 37 (4) ◽  
pp. 535-541
Author(s):  
RYUSUKE IMAI ◽  
TOSHIMASA JINDO ◽  
YUKO MIURA ◽  
KOKI MOCHIDA ◽  
KENJI TAKAMORI ◽  
...  
Keyword(s):  
Organ Culture ◽  
Human Hair ◽  
Hair Follicles

Organ culture conditions of human hair follicles

1992 ◽  
Vol 3 (3) ◽  
pp. 163-171 ◽  
Author(s):  
R IMAI ◽  
Y MIURA ◽  
K MOCHIDA ◽  
T JINDO ◽  
K TAKAMORI ◽  
...  
Keyword(s):  
Organ Culture ◽  
Human Hair ◽  
Culture Conditions ◽  
Hair Follicles

Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp

1992 ◽  
Vol 133 (1) ◽  
pp. 141-147 ◽  
Author(s):  
V. A. Randall ◽  
M. J. Thornton ◽  
A. G. Messenger
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Androgen Receptors ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
The Body ◽  
Follicular Epithelium ◽  
Dermal Papilla Cells ◽  
Age Related

ABSTRACT Androgens stimulate hair growth in many areas, e.g. the beard; they also induce regression and balding on the scalp with increasing age in genetically disposed individuals. The cause(s) of this biological conundrum is unknown but age-related; androgen-potentiated changes also occur in the prostate. The mesenchymederived dermal papilla situated at the base of the hair follicle is thought to play an important role in regulating the growth and development of the follicular epithelium. Since androgens probably act on the hair follicle via the dermal papilla, cultures of dermal papilla cells from human hair follicles with differing responses to androgens in vivo have been established and their ability to bind androgens assessed. Receptor binding was assayed by saturation analysis (0·05–10 nmol/l) using the synthetic non-metabolizable androgen, [3H]mibolerone. Shionogi 115 cells were also assayed as a positive control. Specific high-affinity low-capacity androgen receptors were identified in 12 dermal papilla primary cell lines with similar characteristics to established androgen receptors. Cells from androgen-sensitive follicles (beard, scrotum and pubis) contained higher levels of androgen receptors than those derived from relatively androgeninsensitive non-balding scalp follicles whether the receptor content was calculated in relation to cell number, protein or DNA content of the cells. These results support the hypothesis that androgens act on hair follicles via the dermal papilla in vivo and demonstrate that dermal papilla cells exhibit an altered phenotype in culture which depends on the body site from which they were derived. Cultured human dermal papilla cells should prove a useful model system for studies of the mechanism of androgen action, and further investigations may elucidate the paradox of why bald men can grow beards. Journal of Endocrinology (1992) 133, 141–147

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